The Bax pore in liposomes, Biophysics (Q36501189)

14 August 2017

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title

The Bax pore in liposomes, Biophysics (English)

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14 August 2017

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Schlesinger PH

1

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PubMed ID

16763615

14 August 2017

Saito M

series ordinal

2

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14 August 2017

9 June 2006

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Cell Death & Differentiation

14 August 2017

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14 August 2017

13

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14 August 2017

8

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14 August 2017

1403-1408

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https://scigraph.springernature.com/pub.10.1038/sj.cdd.4401991

14 August 2017

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21 January 2018

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Pro-apoptotic cascade activates BID, which oligomerizes BAK or BAX into pores that result in the release of cytochrome c.

21 January 2018

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A structural view of mitochondria-mediated apoptosis

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401991

BCL-2 family: regulators of cell death

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401991

Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401991

Life-or-death decisions by the Bcl-2 protein family.

21 January 2018

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Insights into programmed cell death through structural biology

21 January 2018

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The Bcl-2 protein family: arbiters of cell survival

21 January 2018

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New members of the Bcl-2 family and their protein partners

21 January 2018

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Bax-independent inhibition of apoptosis by Bcl-XL.

21 January 2018

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BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax.

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401991

Multiple Bcl-2 family members demonstrate selective dimerizations with Bax

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401991

Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401991

Bid induces the oligomerization and insertion of Bax into the outer mitochondrial membrane

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401991

Association of Bax and Bak homo-oligomers in mitochondria. Bax requirement for Bak reorganization and cytochrome c release

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401991

Bcl-2 prevents Bax oligomerization in the mitochondrial outer membrane

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401991

Enforced dimerization of BAX results in its translocation, mitochondrial dysfunction and apoptosis

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401991

X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401991

Comparison of the ion channel characteristics of proapoptotic BAX and antiapoptotic BCL-2.

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401991

Inhibition of Bax channel-forming activity by Bcl-2

21 January 2018

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Channel formation by antiapoptotic protein Bcl-2.

21 January 2018

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Bcl-x(L) forms an ion channel in synthetic lipid membranes.

21 January 2018

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Cytochrome C-mediated apoptosis

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401991

Three-dimensional structure of the apoptosome: implications for assembly, procaspase-9 binding, and activation.

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401991

Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401991

Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401991

Solution structure of the antiapoptotic protein bcl-2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401991

Structure of Bax: coregulation of dimer formation and intracellular localization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401991

Solution structure of BID, an intracellular amplifier of apoptotic signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401991

Solution structure of the proapoptotic molecule BID: a structural basis for apoptotic agonists and antagonists

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401991

Peptides derived from apoptotic Bax and Bid reproduce the poration activity of the parent full-length proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401991

Large structure rearrangement of colicin ia channel domain after membrane binding from 2D 13C spin diffusion NMR.

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401991

Bcl-2 family proteins as ion-channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401991

Colicin crystal structures: pathways and mechanisms for colicin insertion into membranes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401991

Posttranslational N-myristoylation of BID as a molecular switch for targeting mitochondria and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401991

BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401991

Structure-function comparisons of the proapoptotic protein Bax in yeast and mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401991

Proapoptotic protein Bax heterodimerizes with Bcl-2 and homodimerizes with Bax via a novel domain (BH3) distinct from BH1 and BH2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401991

BAX-dependent transport of cytochrome c reconstituted in pure liposomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401991

Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401991

Structure of Bcl-xL-Bak peptide complex: recognition between regulators of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401991

Activation of apoptosis in vivo by a hydrocarbon-stapled BH3 helix

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401991

E1B 19K blocks Bax oligomerization and tumor necrosis factor alpha-mediated apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401991

Regulated targeting of BAX to mitochondria.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401991

Conformation of the Bax C-terminus regulates subcellular location and cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401991

Antimycin A mimics a cell-death-inducing Bcl-2 homology domain 3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401991

Identification of small-molecule inhibitors of interaction between the BH3 domain and Bcl-xL

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401991

NMR studies of the anti-apoptotic protein Bcl-xL in micelles

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401991

Bax is present as a high molecular weight oligomer/complex in the mitochondrial membrane of apoptotic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401991

Bax oligomerization is required for channel-forming activity in liposomes and to trigger cytochrome c release from mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401991

The unfolding story of three-dimensional domain swapping.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401991

Molecular mechanism of domain swapping in proteins: an analysis of slower motions

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401991

A direct optimization approach to hidden Markov modeling for single channel kinetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401991

Oligomeric Bax is a component of the putative cytochrome c release channel MAC, mitochondrial apoptosis-induced channel

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401991

The role of the mitochondrial apoptosis induced channel MAC in cytochrome c release

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401991

Some amphiphilic cations block the mitochondrial apoptosis-induced channel, MAC.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401991

Effects of cytochrome c on the mitochondrial apoptosis-induced channel MAC.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401991

Mechanism of fluorescence concentration quenching of carboxyfluorescein in liposomes: energy transfer to nonfluorescent dimers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401991

Ion channels in liposomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401991

Kinetics of melittin induced pore formation in the membrane of lipid vesicles

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401991

Bid, Bax, and lipids cooperate to form supramolecular openings in the outer mitochondrial membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401991

VDAC2 inhibits BAK activation and mitochondrial apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401991

Bax oligomerization in mitochondrial membranes requires tBid (caspase-8-cleaved Bid) and a mitochondrial protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401991

Fatty acids enhance membrane permeabilization by pro-apoptotic Bax.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401991

Preparation of cell-size unilamellar liposomes with high captured volume and defined size distribution

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401991

Ultrastructural localization of bcl-2 protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401991

7 January 2021

Mitochondrial implication in apoptosis. Towards an endosymbiont hypothesis of apoptosis evolution

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401991

7 January 2021

Conformational changes in BID, a pro-apoptotic BCL-2 family member, upon membrane binding. A site-directed spin labeling study

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401991

7 January 2021

Quantitative studies on the melittin-induced leakage mechanism of lipid vesicles

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401991

7 January 2021

Identifiers

DOI

10.1038/SJ.CDD.4401991

1 reference

PubMed ID

16763615

Dimensions Publication ID

14 August 2017

0 references

1 reference

PubMed ID

16763615