Oncogenesis of RON receptor tyrosine kinase: a molecular target for malignant epithelial cancers (Q36488410)

14 August 2017

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title

Oncogenesis of RON receptor tyrosine kinase: a molecular target for malignant epithelial cancers (English)

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14 August 2017

Ming-Hai Wang

1

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14 August 2017

Hang-Ping Yao

series ordinal

2

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14 August 2017

Yong-Qing Zhou

series ordinal

3

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14 August 2017

1 June 2006

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Acta Pharmacologica Sinica

14 August 2017

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14 August 2017

27

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14 August 2017

6

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14 August 2017

641-650

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https://scigraph.springernature.com/pub.10.1111/j.1745-7254.2006.00361.x

14 August 2017

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Biology of HER2 and its importance in breast cancer

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Overview of treatment results with trastuzumab (Herceptin) in metastatic breast cancer

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Oncogenic and invasive potentials of human macrophage-stimulating protein receptor, the RON receptor tyrosine kinase

21 January 2018

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Macrophage-stimulating protein and RON receptor tyrosine kinase: potential regulators of macrophage inflammatory activities

21 January 2018

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Tumor suppressor genes on chromosome 3p involved in the pathogenesis of lung and other cancers

21 January 2018

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Structure of the promoter for the human macrophage stimulating protein receptor gene.

21 January 2018

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c-Cbl is a critical modulator of the Ron tyrosine kinase receptor

21 January 2018

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Hepatocyte growth factor/scatter factor and its receptor, the c-met proto-oncogene product

21 January 2018

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Chicken macrophage stimulating protein is a ligand of the receptor protein-tyrosine kinase Sea.

21 January 2018

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Cloning and expression of Xenopus HGF-like protein (HLP) and Ron/HLP receptor implicate their involvement in early neural development.

21 January 2018

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Three receptor genes for plasminogen related growth factors in the genome of the puffer fish Fugu rubripes.

21 January 2018

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Concomitant activation of the PI3K-Akt and the Ras-ERK signaling pathways is essential for transformation by the V-SEA tyrosine kinase oncogene

21 January 2018

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Macrophage stimulating protein: purification, partial amino acid sequence, and cellular activity

21 January 2018

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Macrophage stimulating protein (MSP) binds to its receptor via the MSP beta chain

21 January 2018

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Crystal structure of the beta-chain of human hepatocyte growth factor-like/macrophage stimulating protein

21 January 2018

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Characterization of the mouse cDNA and gene coding for a hepatocyte growth factor-like protein: expression during development

21 January 2018

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Overexpression of the RON gene in human breast carcinoma

21 January 2018

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Altered expression of the RON receptor tyrosine kinase in primary human colorectal adenocarcinomas: generation of different splicing RON variants and their oncogenic potential

21 January 2018

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Prognostic significance of co-expression of RON and MET receptors in node-negative breast cancer patients.

21 January 2018

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Co-expression of RON and MET is a prognostic indicator for patients with transitional-cell carcinoma of the bladder

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1745-7254.2006.00361.X

The RON and MET oncogenes are co-expressed in human ovarian carcinomas and cooperate in activating invasiveness

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1745-7254.2006.00361.X

Overexpression and activation of the RON receptor tyrosine kinase in a panel of human colorectal carcinoma cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1745-7254.2006.00361.X

C to A single nucleotide polymorphism in intron 18 of the human MST1R (RON) gene that maps at 3p21.3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1745-7254.2006.00361.X

A splicing variant of the RON transcript induces constitutive tyrosine kinase activity and an invasive phenotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1745-7254.2006.00361.X

The envelope glycoprotein of friend spleen focus-forming virus covalently interacts with and constitutively activates a truncated form of the receptor tyrosine kinase Stk.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1745-7254.2006.00361.X

Fv2 encodes a truncated form of the Stk receptor tyrosine kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1745-7254.2006.00361.X

Truncated RON tyrosine kinase drives tumor cell progression and abrogates cell-cell adhesion through E-cadherin transcriptional repression

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1745-7254.2006.00361.X

Cell motility is controlled by SF2/ASF through alternative splicing of the Ron protooncogene

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1745-7254.2006.00361.X

Constitutive activation of the RON gene promotes invasive growth but not transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1745-7254.2006.00361.X

RNA-mediated gene silencing of the RON receptor tyrosine kinase alters oncogenic phenotypes of human colorectal carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1745-7254.2006.00361.X

Point mutations in the tyrosine kinase domain release the oncogenic and metastatic potential of the Ron receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1745-7254.2006.00361.X

Point mutations and overexpression of Ron induce transformation, tumor formation, and metastasis

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1745-7254.2006.00361.X

MET(PRC) mutations in the Ron receptor result in upregulation of tyrosine kinase activity and acquisition of oncogenic potential

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1745-7254.2006.00361.X

Multiple pulmonary adenomas in the lung of transgenic mice overexpressing the RON receptor tyrosine kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1745-7254.2006.00361.X

Targeted expression of the receptor tyrosine kinase RON in distal lung epithelial cells results in multiple tumor formation: oncogenic potential of RON in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1745-7254.2006.00361.X

Epithelial cell plasticity in development and tumor progression

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1745-7254.2006.00361.X

Leaving the neighborhood: molecular mechanisms involved during epithelial-mesenchymal transition.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1745-7254.2006.00361.X

Collaborative activities of macrophage-stimulating protein and transforming growth factor-beta1 in induction of epithelial to mesenchymal transition: roles of the RON receptor tyrosine kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1745-7254.2006.00361.X

TGF-beta signaling by Smad proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1745-7254.2006.00361.X

The MSP receptor regulates alpha6beta4 and alpha3beta1 integrins via 14-3-3 proteins in keratinocyte migration

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1745-7254.2006.00361.X

Macrophage-stimulating protein activates Ras by both activation and translocation of SOS nucleotide exchange factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1745-7254.2006.00361.X

Macrophage stimulating protein-induced epithelial cell adhesion is mediated by a PI3-K-dependent, but FAK-independent mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1745-7254.2006.00361.X

Oncogenic mutants of RON and MET receptor tyrosine kinases cause activation of the beta-catenin pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1745-7254.2006.00361.X

A multifunctional docking site mediates signaling and transformation by the hepatocyte growth factor/scatter factor receptor family

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1745-7254.2006.00361.X

Integrin-mediated RON growth factor receptor phosphorylation requires tyrosine kinase activity of both the receptor and c-Src

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1745-7254.2006.00361.X

Activation of the RON receptor tyrosine kinase by macrophage-stimulating protein inhibits inducible cyclooxygenase-2 expression in murine macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1745-7254.2006.00361.X

Requirement of both tyrosine residues 1330 and 1337 in the C-terminal tail of the RON receptor tyrosine kinase for epithelial cell scattering and migration

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1745-7254.2006.00361.X

The Ron oncogenic activity induced by the MEN2B-like substitution overcomes the requirement for the multifunctional docking site.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1745-7254.2006.00361.X

The C terminus of RON tyrosine kinase plays an autoinhibitory role

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1745-7254.2006.00361.X

The soluble sema domain of the RON receptor inhibits macrophage-stimulating protein-induced receptor activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1745-7254.2006.00361.X

10.1111/J.1745-7254.2006.00361.X

21 January 2018

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14 August 2017

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