Double minutes, cytogenetic equivalents of gene amplification, in human neoplasia - a review (Q36350678)

13 August 2017

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title

Double minutes, cytogenetic equivalents of gene amplification, in human neoplasia - a review (English)

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13 August 2017

Erich Gebhart

1

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13 August 2017

1 December 2005

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Clinical and Translational Oncology

13 August 2017

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13 August 2017

7

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13 August 2017

477-485

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13 August 2017

11

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https://scigraph.springernature.com/pub.10.1007/bf02717000

13 August 2017

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cites work

Trisomy 4 associated with double minute chromosomes and MYC amplification in acute myeloblastic leukemia

1 reference

https://api.crossref.org/works/10.1007%2FBF02717000

In vivo elimination of acentric double minutes containing amplified MYCN from neuroblastoma tumor cells through the formation of micronuclei

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF02717000

MYCN gene amplification. Identification of cell populations containing double minutes and homogeneously staining regions in neuroblastoma tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF02717000

HER-2/neu oncogene amplification by fluorescence in situ hybridization in epithelial tumors of the ovary

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF02717000

Amplified c-MYC sequences localized by fluorescence in-situ hybridization on double minute chromosomes in acute myeloid leukemias

21 January 2018

1 reference

12 December 2020

Cytogenetic evolution of MYCN and MDM2 amplification in the neuroblastoma LS tumour and its cell line

1 reference

12 December 2020

C-myc amplification, double minutes and homogenous staining regions in a case of AML.

1 reference

12 December 2020

Updates on the cytogenetics and molecular genetics of bone and soft tissue tumors: liposarcoma

1 reference

12 December 2020

Molecular structure of double-minute chromosomes bearing amplified copies of the epidermal growth factor receptor gene in gliomas

1 reference

12 December 2020

Chromosomal changes and correspondingly altered proto-oncogene expression in human gliomas. Value of combined cytogenetic and molecular genetic analysis.

1 reference

12 December 2020

Relational mapping of MYCN and DDXI in band 2p24 and analysis of amplicon arrays in double minute chromosomes and homogeneously staining regions by use of free chromatin FISH.

1 reference

12 December 2020

Combined M-FISH and CGH analysis allows comprehensive description of genetic alterations in neuroblastoma cell lines

1 reference

12 December 2020

Cytogenetic analysis of three variants of clival chordoma

1 reference

12 December 2020

MYCN Amplification in Neuroblastoma: a Paradigm for the Clinical Use of an Oncogene

1 reference

12 December 2020

The application of comparative genomic hybridization as an additional tool in the chromosome analysis of acute myeloid leukemia and myelodysplastic syndromes

1 reference

12 December 2020

Analysis of double minutes and double minute-like chromatin in human and murine tumor cells using antikinetochore antibodies

1 reference

12 December 2020

Gene amplification causes overproduction of the first three enzymes of UMP synthesis in N-(phosphonacetyl)-L-aspartate-resistant hamster cells

1 reference

12 December 2020

Advances in the analysis of chromosome alterations in human lung carcinomas

1 reference

12 December 2020

Updates on the cytogenetics and molecular genetics of bone and soft tissue tumors: osteosarcoma and related tumors

1 reference

12 December 2020

Extrachromosomal gene amplification in acute myeloid leukemia; Characterization by metaphase analysis, comparative genomic hybridization, and semi-quantitative PCR

1 reference

12 December 2020

Analysis of the replication mode of double minutes using the PCC technique combined with BrdUrd labeling

1 reference

12 December 2020

Have double minutes functioning centromeres?

1 reference

12 December 2020

Chromosomal localization of amplified N-myc in neuroblastoma cells using a biotinylated probe

1 reference

12 December 2020

Double minutes in the papillary thyroid cancer cell line PTC-1113A.

1 reference

12 December 2020

Double minute chromosomes in monoblastic (M5) and myeloblastic (M2) acute myeloid leukemia: two case reports and a review of literature

1 reference

12 December 2020

Chromosome alterations in human small cell lung cancer: frequent involvement of 5q

1 reference

12 December 2020

De novo erythroleukemia chromosome features include multiple rearrangements, with special involvement of chromosomes 11 and 19.

1 reference

12 December 2020

Selective elimination of acentric double minutes from cancer cells through the extrusion of micronuclei

1 reference

12 December 2020

Genomic imbalances in drug-resistant T-cell acute lymphoblastic CEM leukemia cell lines.

1 reference

12 December 2020

A new case of acute nonlymphocytic leukemia (French-American-British subtype M1) with double minutes and c-MYC amplification

1 reference

12 December 2020

Weekly trastuzumab and paclitaxel therapy for metastatic breast cancer with analysis of efficacy by HER2 immunophenotype and gene amplification.

1 reference

12 December 2020

Double minutes are frequently found in ovarian carcinomas.

1 reference

12 December 2020

Amplification of the MLL gene on double minutes, a homogeneously staining region, and ring chromosomes in five patients with acute myeloid leukemia or myelodysplastic syndrome

1 reference

12 December 2020

Amplified dihydrofolate reductase genes are localized to a homogeneously staining region of a single chromosome in a methotrexate-resistant Chinese hamster ovary cell line

1 reference

12 December 2020

Amplification of chromosome 1 sequences in lipomatous tumors and other sarcomas.

1 reference

12 December 2020

Alternative pathways of MYCN gene copy number increase in primary neuroblastoma tumors

1 reference

12 December 2020

Relationship between gene amplification and chromosomal deviations in malignant human gliomas

1 reference

12 December 2020

Homogeneously staining chromosomal regions contain amplified copies of an abundantly expressed cellular oncogene (c-myc) in malignant neuroendocrine cells from a human colon carcinoma

1 reference

12 December 2020

Characterization of the C-MYC amplicon in a case of acute myeloid leukemia with double minute chromosomes

1 reference

12 December 2020

Fusion of NUP214 to ABL1 on amplified episomes in T-cell acute lymphoblastic leukemia

1 reference

12 December 2020

Amplified dihydrofolate reductase genes in unstably methotrexate-resistant cells are associated with double minute chromosomes

1 reference

12 December 2020

MYC is not overexpressed in a case of chronic myelomonocytic leukemia with MYC-containing double minutes

1 reference

12 December 2020

Updates on the cytogenetics and molecular genetics of bone and soft tissue tumors: chondrosarcoma and other cartilaginous neoplasms

1 reference

12 December 2020

Cloning of a non-c-myc DNA fragment from the double minutes of a human colon carcinoid cell line

1 reference

12 December 2020

Onc gene amplification in promyelocytic leukaemia cell line HL-60 and primary leukaemic cells of the same patient

1 reference

12 December 2020

Trisomy 4 and double minutes in acute myeloid leukemia: further evidence that double minutes can occur as the primary cytogenetic abnormality

1 reference

12 December 2020

MDM2 gene amplification correlates with ring chromosome in soft tissue tumors

1 reference

12 December 2020

Overview of monoclonal antibodies in cancer therapy: present and promise

1 reference

12 December 2020

A new approach of brain tumors: the cytogenetic study.

1 reference

12 December 2020

Chromosomal aberrations in breast cancer: a comparison between cytogenetics and comparative genomic hybridization

1 reference

12 December 2020

Incidence of double minutes, cytogenetic equivalents of gene amplification, in human carcinoma cells

1 reference

12 December 2020

Topology of double minutes (dmins) and homogeneously staining regions (HSRs) in nuclei of human neuroblastoma cell lines

1 reference

12 December 2020

Molecular cytogenetic analysis of a pleuropulmonary blastoma

1 reference

12 December 2020

Updates on the cytogenetics and molecular genetics of bone and soft tissue tumors: leiomyoma

1 reference

12 December 2020

Oncogenes as novel targets for cancer therapy (part I): growth factors and protein tyrosine kinases

1 reference

12 December 2020

Patterns of BrdU incorporation in homogeneously staining regions and double minutes

1 reference

12 December 2020

Double minutes and c-MYC amplification in acute myelogenous leukemia: Are they prognostic factors?

1 reference

12 December 2020

When, where and how the bridge breaks: anaphase bridge breakage plays a crucial role in gene amplification and HSR generation

1 reference

12 December 2020

Presence of telomeric sequences on deleted chromosomes and their absence on double minutes in cell line HL-60.

1 reference

12 December 2020

Cytogenetic and molecular findings related to rhabdomyosarcoma. An analysis of seven cases

1 reference

12 December 2020

Contribution of fluorescence in situ hybridization analyses to the characterization of masked and complex Philadelphia chromosome translocations in chronic myelocytic leukemia

1 reference

12 December 2020

Double minute chromosomes and homogeneously staining regions in tumors taken directly from patients versus in human tumor cell lines

1 reference

12 December 2020

Oncogenic role of eIF-5A2 in the development of ovarian cancer

1 reference

12 December 2020

Amplification and expression of the c-myc oncogene in human lung cancer cell lines

1 reference

12 December 2020

Double minute chromosomes in human leukemia

1 reference

12 December 2020

Targeting HER2 as a therapeutic strategy for breast cancer: a paradigmatic shift of drug development in oncology.

1 reference

12 December 2020

c-Met as a target for human cancer and characterization of inhibitors for therapeutic intervention

1 reference

12 December 2020

Chromosome abnormalities in human non-small cell lung cancer

1 reference

12 December 2020

Metaphase chromosome anomaly: association with drug resistance and cell-specific products

1 reference

12 December 2020

Distinct sequences on 11q13.5 and 11q23-24 are frequently coamplified with MLL in complexly organized 11q amplicons in AML/MDS patients

1 reference

12 December 2020

Updates on the cytogenetics and molecular genetics of bone and soft tissue tumors: lipoma

1 reference

12 December 2020

HER-2/neu oncogene amplification in stage I and stage III ovarian papillary serous carcinoma

1 reference

12 December 2020

Amplification of endogenous myc-related DNA sequences in a human myeloid leukaemia cell line

1 reference

12 December 2020

Cryptic ins(2;11) with clonal evolution showing amplification of 11q23-q25 either on hsr(11) or on dmin, in a patient with AML-M2.

1 reference

12 December 2020

Double minute chromosomes in a patient with myelodysplastic syndrome transforming into acute myeloid leukemia

1 reference

12 December 2020

Apparent lack of telomere sequences on double minute chromosomes

1 reference

12 December 2020

Cytogenetics and molecular genetics of lung cancer

1 reference

12 December 2020

Coamplification of simple repetitive DNA fingerprint fragments and the EGFR gene in human gliomas.

1 reference

12 December 2020

Double minutes in human tumor cells

1 reference

12 December 2020

Updates on the cytogenetics and molecular genetics of bone and soft tissue tumors. Synovial sarcoma

1 reference

12 December 2020

[c-myc gene amplification and N-ras transforming gene in two cases of acute myelocytic leukemia with double minute chromosomes]

1 reference

12 December 2020

Nucleus extraction from single mounted tissue sections

1 reference

12 December 2020

Cytogenetics and DNA amplification in colorectal cancers

1 reference

12 December 2020

17p Deletion in acute myeloid leukemia and myelodysplastic syndrome. Analysis of breakpoints and deleted segments by fluorescence in situ

1 reference

12 December 2020

Amplification of cellular oncogenes: a predictor of clinical outcome in human cancer

1 reference

12 December 2020

Molecular therapy of head and neck cancer.

1 reference

12 December 2020

Ultrastructural organization of double minute chromosomes and HSR regions in human colon carcinoma cells

1 reference

12 December 2020

Amplification of c-myc and pvt-1 homologous sequences in acute nonlymphatic leukemia

1 reference

12 December 2020

Molecularly targeted therapies for breast cancer

1 reference

12 December 2020

Updates on the cytogenetics and molecular genetics of bone and soft tissue tumors. gastrointestinal stromal tumors

1 reference

12 December 2020

Multicolour fluorescence in situ hybridization analysis of t(14;18)-positive follicular lymphoma and correlation with gene expression data and clinical outcome

1 reference

12 December 2020

MYC amplification in two further cases of acute myeloid leukemia with trisomy 4 and double minute chromosomes

1 reference

12 December 2020

MLL amplification in acute leukaemia: a United Kingdom Cancer Cytogenetics Group (UKCCG) study

1 reference

12 December 2020

Updates on cytogenetics and molecular genetics of bone and soft tissue tumors: Ewing sarcoma and peripheral primitive neuroectodermal tumors

1 reference

12 December 2020

Are double minutes chromosomes?

1 reference

12 December 2020

Assessment of the HER2 status in breast cancer by fluorescence in situ hybridization: a technical review with interpretive guidelines

1 reference

12 December 2020

c-myc amplification in a preleukemia patient with trisomy 4 and double minutes: review of the unique coexistence of these two chromosome abnormalities in acute myelogenous leukemia

1 reference

12 December 2020

Identification of a commonly amplified 4.3 Mb region with overexpression of C8FW, but not MYC in MYC-containing double minutes in myeloid malignancies.

1 reference

12 December 2020

Localization of amplified MYC gene sequences to double minute chromosomes in acute myelogenous leukemia.

1 reference

12 December 2020

Clinical laboratory assays for HER-2/neu amplification and overexpression: quality assurance, standardization, and proficiency testing

1 reference

12 December 2020

Updates on the cytogenetics and molecular genetics of bone and soft tissue tumors. Dermatofibrosarcoma protuberans and giant cell fibroblastoma

1 reference

12 December 2020

Co-existence of pseudo-Chediak-Higashi anomaly and double minutes containing C-MYC oncogene in three patients with AML M2

1 reference

12 December 2020

Rings and double minutes in a case with blastic phase of chronic myelocytic leukemia

1 reference

12 December 2020

Microdissection and microcloning of chromosomal alterations in human breast cancer

1 reference

12 December 2020

Oncogene amplification in human gliomas: a molecular cytogenetic analysis

1 reference

12 December 2020

Jumping translocation of homogeneously staining region and tetraploidy with double minutes in acute myelomonocytic leukemia

1 reference

12 December 2020

Identification of the origin of double minutes in normal human cells by laser-based chromosome microdissection approach

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12 December 2020

Comprehensive molecular cytogenetic investigation of chromosomal abnormalities in human medulloblastoma cell lines and xenograft

1 reference

12 December 2020

Gene amplification and drug resistance

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12 December 2020

Antifolate-resistant Chinese hamster cells. Evidence for dihydrofolate reductase gene amplification among independently derived sublines overproducing different dihydrofolate reductases

1 reference

12 December 2020

The HER-2/neu oncogene in breast cancer: prognostic factor, predictive factor, and target for therapy.

1 reference

12 December 2020

Double minutes replicate once during S phase of the cell cycle

1 reference

12 December 2020

Amplification of the human dihydrofolate reductase gene via double minutes is initiated by chromosome breaks

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12 December 2020

Chromosomes of human cancer cells

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12 December 2020

Chromosome instability in human lung cancers: possible underlying mechanisms and potential consequences in the pathogenesis

1 reference

12 December 2020

Double minute chromosomes in acute myeloid leukemia and myelodysplastic syndrome: identification of new amplification regions by fluorescence in situ hybridization and spectral karyotyping

1 reference

12 December 2020

Structure and organization of amplified DNA on double minutes containing the mdm2 oncogene

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12 December 2020

Identifiers

DOI

10.1007/BF02717000

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13 August 2017

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PubMed ID

16373058