Targeting the insulin-like growth factor-1 receptor to overcome bortezomib resistance in preclinical models of multiple myeloma. (Q36333522)

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12 February 2020

title

Targeting the insulin-like growth factor-1 receptor to overcome bortezomib resistance in preclinical models of multiple myeloma (English)

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12 February 2020

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2

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17

Robert Z Orlowski

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12 February 2020

15

Jatin J Shah

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12 February 2020

author name string

Deborah J Kuhn

1

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12 February 2020

Richard J Jones

3

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12 February 2020

Richard Woessner

4

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12 February 2020

Chad C Bjorklund

5

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12 February 2020

Wencai Ma

6

1 reference

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12 February 2020

R Eric Davis

7

1 reference

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12 February 2020

Pei Lin

8

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12 February 2020

Hua Wang

9

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12 February 2020

Timothy L Madden

10

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12 February 2020

Caimiao Wei

11

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12 February 2020

Veerabhadran Baladandayuthapani

12

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12 February 2020

Michael Wang

13

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12 February 2020

Sheeba K Thomas

14

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12 February 2020

Donna M Weber

16

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12 February 2020

language of work or name

English

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publication date

29 August 2012

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12 February 2020

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12 February 2020

volume

120

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12 February 2020

issue

16

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12 February 2020

page(s)

3260-3270

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A re-annotation pipeline for Illumina BeadArrays: improving the interpretation of gene expression data

12 February 2020

cites work

1 reference

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Proteasome inhibitors in the treatment of multiple myeloma

30 September 2017

1 reference

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Antimyeloma activity of the orally bioavailable dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235.

30 September 2017

1 reference

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Clinical challenges associated with bortezomib therapy in multiple myeloma and Waldenströms Macroglobulinemia

30 September 2017

1 reference

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Different mutants of PSMB5 confer varying bortezomib resistance in T lymphoblastic lymphoma/leukemia cells derived from the Jurkat cell line

30 September 2017

1 reference

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The role of IGF-1 as a major growth factor for myeloma cell lines and the prognostic relevance of the expression of its receptor

30 September 2017

1 reference

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Characterization of the ubiquitin-proteasome system in bortezomib-adapted cells

30 September 2017

1 reference

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Targeted inhibition of the immunoproteasome is a potent strategy against models of multiple myeloma that overcomes resistance to conventional drugs and nonspecific proteasome inhibitors

30 September 2017

1 reference

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In vitro activity of bortezomib in cultures of patient tumour cells--potential utility in haematological malignancies

30 September 2017

1 reference

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Canonical and non-canonical JAK-STAT signaling

30 September 2017

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Insulin-like growth factor-I activates gene transcription programs strongly associated with poor breast cancer prognosis

30 September 2017

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An observational, retrospective analysis of retreatment with bortezomib for multiple myeloma

30 September 2017

1 reference

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Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity

30 September 2017

1 reference

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Molecular basis of bortezomib resistance: proteasome subunit beta5 (PSMB5) gene mutation and overexpression of PSMB5 protein

30 September 2017

1 reference

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Proteasome beta subunit pharmacogenomics: gene resequencing and functional genomics

30 September 2017

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Enhanced identification and biological validation of differential gene expression via Illumina whole-genome expression arrays through the use of the model-based background correction methodology

30 September 2017

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Proteasome inhibitors in cancer therapy: lessons from the first decade

30 September 2017

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Statistical issues in the analysis of Illumina data

30 September 2017

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The proteasome maturation protein POMP facilitates major steps of 20S proteasome formation at the endoplasmic reticulum

30 September 2017

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Inhibition of Akt induces significant downregulation of survivin and cytotoxicity in human multiple myeloma cells

30 September 2017

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Potent activity of carfilzomib, a novel, irreversible inhibitor of the ubiquitin-proteasome pathway, against preclinical models of multiple myeloma

30 September 2017

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Increased expression and altered subunit composition of proteasomes induced by continuous proteasome inhibition establish apoptosis resistance and hyperproliferation of Burkitt lymphoma cells

30 September 2017

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Perifosine, an oral bioactive novel alkylphospholipid, inhibits Akt and induces in vitro and in vivo cytotoxicity in human multiple myeloma cells

30 September 2017

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30 September 2017

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Development of the proteasome inhibitor Velcade (Bortezomib).

30 September 2017

1 reference

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A comparison of normalization methods for high density oligonucleotide array data based on variance and bias

30 September 2017

1 reference

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Molecular sequelae of proteasome inhibition in human multiple myeloma cells

30 September 2017

1 reference

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20S proteasome biogenesis

30 September 2017

1 reference

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Structure of 20S proteasome from yeast at 2.4 A resolution

30 September 2017

1 reference

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Insulin-like growth factor I is a growth and survival factor in human multiple myeloma cell lines.

30 September 2017

1 reference

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Functional insulin and insulin-like growth factor-1 receptors are preferentially expressed in multiple myeloma cell lines as compared to B-lymphoblastoid cell lines.

30 September 2017

1 reference

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29 June 2018

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Utility of bortezomib retreatment in relapsed or refractory multiple myeloma patients: a multicenter case series.

22 September 2018

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Insulin-like growth factor-1 delays Fas-mediated apoptosis in human neutrophils through the phosphatidylinositol-3 kinase pathway

22 September 2018

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Point mutation of the proteasome beta5 subunit gene is an important mechanism of bortezomib resistance in bortezomib-selected variants of Jurkat T cell lymphoblastic lymphoma/leukemia line

22 September 2018

1 reference

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Activity of bortezomib in adult de novo and relapsed acute myeloid leukemia

22 September 2018

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The mechanism of cross-resistance to proteasome inhibitor bortezomib and overcoming resistance in Ewing's family tumor cells.

22 September 2018

1 reference

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No evidence of mutations of the PSMB5 (beta-5 subunit of proteasome) in a case of myeloma with clinical resistance to Bortezomib

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3476538

Clinical course of patients with relapsed multiple myeloma

22 September 2018

1 reference

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Transformation of a MGUS to overt multiple myeloma: the possible role of a pituitary macroadenoma secreting high levels of insulin-like growth factor 1 (IGF-1).

22 September 2018

1 reference

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Structure and assembly of the 20S proteasome

22 September 2018

1 reference

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IGF-1R is overexpressed in poor-prognostic subtypes of multiple myeloma

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3476538

Insulin-like growth factor I is a dual effector of multiple myeloma cell growth

5 December 2018

1 reference

12 December 2020

Serum insulinlike growth factor is not elevated in patients with multiple myeloma but is still a prognostic factor

1 reference

12 December 2020

CD221 (IGF-1R) is aberrantly expressed in multiple myeloma, in relation to disease severity

1 reference

12 December 2020

Picropodophyllotoxin or podophyllotoxin does not induce cell death via insulin-like growth factor-I receptor

1 reference

12 December 2020

Knockdown of PgP resensitizes leukemic cells to proteasome inhibitors

1 reference

12 December 2020

1 reference

12 December 2020

1 reference

12 December 2020

10.1182/BLOOD-2011-10-386789

Identifiers

DOI

1 reference

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12 February 2020

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12 February 2020

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