Development of the proteasome inhibitor Velcade (Bortezomib). (Q34327233)

1 August 2017

1 reference

title

Development of the proteasome inhibitor Velcade (Bortezomib). (English)

1 reference

1 August 2017

Julian Adams

1

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PubMed ID

15199612

1 August 2017

Michael Kauffman

series ordinal

2

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PubMed ID

15199612

1 August 2017

language of work or name

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1 January 2004

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1 August 2017

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1 August 2017

22

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1 August 2017

2

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1 August 2017

304-311

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Chemosensitization of pancreatic cancer by inhibition of the 26S proteasome

1 August 2017

1 reference

https://api.crossref.org/works/10.1081%2FCNV-120030218

26S proteasome inhibition induces apoptosis and limits growth of human pancreatic cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-120030218

Structure of 20S proteasome from yeast at 2.4 A resolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-120030218

Crystal structure of the 20S proteasome from the archaeon T. acidophilum at 3.4 A resolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-120030218

Catalytic mechanism of the 20S proteasome of Thermoplasma acidophilum revealed by X-ray crystallography

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-120030218

Cleavage motifs of the yeast 20S proteasome beta subunits deduced from digests of enolase 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-120030218

Development of the proteasome inhibitor PS-341.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-120030218

p53-dependent cell cycle arrest induced by N-acetyl-L-leucinyl-L-leucinyl-L-norleucinal in platelet-derived growth factor-stimulated human fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-120030218

Protease inhibitor-induced apoptosis: accumulation of wt p53, p21WAF1/CIP1, and induction of apoptosis are independent markers of proteasome inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-120030218

p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-120030218

How proteolysis drives the cell cycle

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-120030218

Role of the ubiquitin-proteasome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-120030218

Proteasome inhibition: a new strategy in cancer treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-120030218

Activation of the cell death program by inhibition of proteasome function

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-120030218

Novel dipeptidyl proteasome inhibitors overcome Bcl-2 protective function and selectively accumulate the cyclin-dependent kinase inhibitor p27 and induce apoptosis in transformed, but not normal, human fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-120030218

Transcription factor NF-kappaB is constitutively activated in acute lymphoblastic leukemia cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-120030218

New insights into role of microenvironment in multiple myeloma

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-120030218

Control of oncogenesis and cancer therapy resistance by the transcription factor NF-kappaB.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-120030218

Signal-induced degradation of I kappa B alpha requires site-specific ubiquitination

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-120030218

Signal-induced ubiquitination of IkappaBalpha by the F-box protein Slimb/beta-TrCP

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-120030218

The SCFbeta-TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in IkappaBalpha and beta-catenin and stimulates IkappaBalpha ubiquitination in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-120030218

Stimulation-dependent I kappa B alpha phosphorylation marks the NF-kappa B inhibitor for degradation via the ubiquitin-proteasome pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-120030218

Critical role for lysines 21 and 22 in signal-induced, ubiquitin-mediated proteolysis of I kappa B-alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-120030218

Signal-induced site-specific phosphorylation targets I kappa B alpha to the ubiquitin-proteasome pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-120030218

Role of IkappaBalpha ubiquitination in signal-induced activation of NFkappaB in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-120030218

The Rel/NF-kappaB family directly activates expression of the apoptosis inhibitor Bcl-x(L).

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-120030218

NF-kappaB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-120030218

NF-kappaB induces expression of the Bcl-2 homologue A1/Bfl-1 to preferentially suppress chemotherapy-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-120030218

The prosurvival Bcl-2 homolog Bfl-1/A1 is a direct transcriptional target of NF-kappaB that blocks TNFalpha-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-120030218

Enhancement of radiosensitivity by proteasome inhibition: implications for a role of NF-kappaB.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-120030218

Proteasome inhibition in cancer: development of PS-341.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-120030218

Increased sensitivity of CLL-derived lymphocytes to apoptotic death activation by the proteasome-specific inhibitor lactacystin

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-120030218

21 January 2018

Identifiers

DOI

10.1081/CNV-120030218

1 reference

1 August 2017

1 reference

PubMed ID

15199612