Pathophysiological basis for antioxidant therapy in chronic liver disease (Q36316956)

13 August 2017

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title

Pathophysiological basis for antioxidant therapy in chronic liver disease (English)

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13 August 2017

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chronic liver disease

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author name string

Jesús Medina

series ordinal

1

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PubMed ID

16296871

13 August 2017

Ricardo Moreno-Otero

series ordinal

2

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13 August 2017

1 January 2005

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13 August 2017

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13 August 2017

65

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13 August 2017

17

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13 August 2017

2445-2461

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https://scigraph.springernature.com/pub.10.2165/00003495-200565170-00003

13 August 2017

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CYP2E1 is not involved in early alcohol-induced liver injury

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Silymarin in the treatment of patients with primary biliary cirrhosis with a suboptimal response to ursodeoxycholic acid.

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An NO derivative of ursodeoxycholic acid protects against Fas-mediated liver injury by inhibiting caspase activity

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Effect of chronic hypoxia on detoxication enzymes in rat liver

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12 December 2020

Polyenylphosphatidylcholine decreases alcohol-induced oxidative stress in the baboon

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A time-dependent balance between endothelins and nitric oxide regulating portal resistance after endotoxin.

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Nitric oxide release and enhancement of lipid peroxidation in regenerating rat liver

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Iron-dependent activation of NF-kappaB in Kupffer cells: a priming mechanism for alcoholic liver disease

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12 December 2020

Inducible nitric oxide synthase expression in chronic viral hepatitis. Evidence for a virus-induced gene upregulation.

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PPARalpha ligands activate antioxidant enzymes and suppress hepatic fibrosis in rats

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Hepatitis C virus core protein, cytochrome P450 2E1, and alcohol produce combined mitochondrial injury and cytotoxicity in hepatoma cells.

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12 December 2020

Feeding S-adenosyl-L-methionine attenuates both ethanol-induced depletion of mitochondrial glutathione and mitochondrial dysfunction in periportal and perivenous rat hepatocytes

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Impaired liver regeneration in inducible nitric oxide synthasedeficient mice

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Plasma antioxidant levels in chronic cholestatic liver diseases

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Successful interferon therapy reverses enhanced hepatic iron accumulation and lipid peroxidation in chronic hepatitis C

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Inducible nitric oxide synthase is required in alcohol-induced liver injury: studies with knockout mice

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A pilot trial of pentoxifylline in nonalcoholic steatohepatitis.

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12 December 2020

Oxidants and antioxidants in alcohol-induced liver disease

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12 December 2020

Superoxide radical and superoxide dismutases

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12 December 2020

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12 December 2020

Effects of oral S-adenosyl-L-methionine on hepatic glutathione in patients with liver disease

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12 December 2020

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12 December 2020

Oxidative stress in the absence of inflammation in a mouse model for hepatitis C virus-associated hepatocarcinogenesis

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12 December 2020

Nitric oxide reaction with lipid peroxyl radicals spares alpha-tocopherol during lipid peroxidation. Greater oxidant protection from the pair nitric oxide/alpha-tocopherol than alpha-tocopherol/ascorbate

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12 December 2020

Betaine, a promising new agent for patients with nonalcoholic steatohepatitis: results of a pilot study

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12 December 2020

Superoxide dismutase in patients with chronic hepatitis C virus infection

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12 December 2020

The role of statins in oxidative stress and cardiovascular disease

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12 December 2020

GSH transport in mitochondria: defense against TNF-induced oxidative stress and alcohol-induced defect.

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12 December 2020

High-dose vitamin E supplementation does not diminish ribavirin-associated haemolysis in hepatitis C treatment with combination standard alpha-interferon and ribavirin

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12 December 2020

Oxidant stress is a significant feature of primary biliary cirrhosis.

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12 December 2020

S-nitrosoglutathione enhances neutrophil DNA fragmentation and cell death

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12 December 2020

S-Adenosylmethionine revisited: its essential role in the regulation of liver function

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12 December 2020

Identification and characterization of autoantibodies against catalase and alpha-enolase in patients with primary sclerosing cholangitis.

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12 December 2020

Cytokines and NASH: a pilot study of the effects of lifestyle modification and vitamin E.

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12 December 2020

Evidence for mitochondrial DNA damage by lipid peroxidation

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12 December 2020

Hepatocellular mitochondrial alterations in patients with chronic hepatitis C: ultrastructural and biochemical findings

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12 December 2020

Hepatitis B virus X protein transactivates inducible nitric oxide synthase gene promoter through the proximal nuclear factor kappaB-binding site: evidence that cytoplasmic location of X protein is essential for gene transactivation

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12 December 2020

Expression of telomerase activity and oxidative stress in human hepatocellular carcinoma with cirrhosis

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12 December 2020

Enhanced intrahepatic inducible nitric oxide synthase expression and nitrotyrosine accumulation in primary biliary cirrhosis and autoimmune hepatitis

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12 December 2020

Ursodeoxycholic acid protects against secondary biliary cirrhosis in rats by preventing mitochondrial oxidative stress.

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12 December 2020

S-adenosyl-L-methionine synthetase and phospholipid methyltransferase are inhibited in human cirrhosis

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12 December 2020

Allopurinol prevents early alcohol-induced liver injury in rats

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12 December 2020

Activation of hepatic stellate cells by TGF alpha and collagen type I is mediated by oxidative stress through c-myb expression

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12 December 2020

Alcohol and mitochondria: a dysfunctional relationship

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12 December 2020

Ethanol stimulates the production of reactive oxygen species at mitochondrial complexes I and III.

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12 December 2020

S-adenosylmethionine deficiency and TNF-alpha in lipopolysaccharide-induced hepatic injury.

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12 December 2020

Nitric oxide prevents tumor necrosis factor alpha-induced rat hepatocyte apoptosis by the interruption of mitochondrial apoptotic signaling through S-nitrosylation of caspase-8.

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12 December 2020

Inhibition of nitric oxide synthesis during endotoxemia promotes intrahepatic thrombosis and an oxygen radical-mediated hepatic injury

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12 December 2020

Mitochondrial injury, oxidative stress, and antioxidant gene expression are induced by hepatitis C virus core protein

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12 December 2020

Cellular thiols and redox-regulated signal transduction.

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12 December 2020

Effect of vitamin E on serum aminotransferase and thioredoxin levels in patients with viral hepatitis C.

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12 December 2020

Plasma transforming growth factor-beta1 level and efficacy of alpha-tocopherol in patients with non-alcoholic steatohepatitis: a pilot study

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12 December 2020

S-adenosylmethionine in alcoholic liver cirrhosis: a randomized, placebo-controlled, double-blind, multicenter clinical trial.

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12 December 2020

Evidence for nitric oxide-mediated oxidative damage in chronic inflammation. Nitrotyrosine in serum and synovial fluid from rheumatoid patients

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12 December 2020

S-adenosylmethionine synthesis: molecular mechanisms and clinical implications

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12 December 2020

A randomized placebo controlled trial of vitamin E for alcoholic hepatitis

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12 December 2020

Polyunsaturated lecithin prevents acetaldehyde-mediated hepatic collagen accumulation by stimulating collagenase activity in cultured lipocytes

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12 December 2020

A role for inducible nitric oxide biosynthesis in the liver in inflammation and in the allogeneic immune response

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12 December 2020

Nitric Oxide. IV. Determinants of nitric oxide protection and toxicity in liver

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12 December 2020

Nitric oxide in liver injury

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12 December 2020

Intrahepatic accumulation of nitrotyrosine in chronic viral hepatitis is associated with histological severity of liver disease

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12 December 2020

Hepatic cytochrome P450 2E1 is increased in patients with nonalcoholic steatohepatitis

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12 December 2020

Immunopathogenesis of cholestatic autoimmune liver diseases

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12 December 2020

CYP2E1 and CYP4A as microsomal catalysts of lipid peroxides in murine nonalcoholic steatohepatitis

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12 December 2020

New concepts of the pathogenesis of alcoholic liver disease lead to novel treatments

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12 December 2020

Steatohepatitis: a tale of two "hits"?

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12 December 2020

Antioxidants attenuate nuclear factor-kappa B activation and tumor necrosis factor-alpha production in alcoholic hepatitis patient monocytes and rat Kupffer cells, in vitro

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12 December 2020

Review article: immunopathogenetic and therapeutic aspects of autoimmune hepatitis

1 reference

12 December 2020

Randomized controlled trial of silymarin treatment in patients with cirrhosis of the liver

1 reference

12 December 2020

Oxygen regulation of gene expression: a study in opposites

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12 December 2020

Approach to the pathogenesis and treatment of nonalcoholic steatohepatitis

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12 December 2020

Decreased activity of scavenger enzymes in human hepatocellular carcinoma, but not in liver metastases

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12 December 2020

Increased expression of an inducible isoform of nitric oxide synthase and the formation of peroxynitrite in colonic mucosa of patients with active ulcerative colitis

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12 December 2020

Effects of long-term vitamin E supplementation in alcoholic cirrhotics

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12 December 2020

Role of cytochrome P4502E1-dependent formation of hydroxyethyl free radical in the development of liver damage in rats intragastrically fed with ethanol

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12 December 2020

Drug-induced hepatotoxicity.

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12 December 2020

Obesity induces expression of uncoupling protein-2 in hepatocytes and promotes liver ATP depletion

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12 December 2020

Effects of hypobaric hypoxia on antioxidant enzymes in rats

1 reference

12 December 2020

Cytochromes P450 and metabolism of xenobiotics

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12 December 2020

A pilot study of the effects of d-alpha-tocopherol on hepatic stellate cell activation in chronic hepatitis C.

1 reference

12 December 2020

Zinc, copper, and superoxide dismutase in hepatocellular carcinoma

1 reference

12 December 2020

Hepatic cytochrome P450 2E1 activity in nondiabetic patients with nonalcoholic steatohepatitis

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12 December 2020

Effects of silymarin in alcoholic patients with cirrhosis of the liver: results of a controlled, double-blind, randomized and multicenter trial.

1 reference

12 December 2020

Reduced mRNA abundance of the main enzymes involved in methionine metabolism in human liver cirrhosis and hepatocellular carcinoma

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12 December 2020

Alcohol-induced free radicals in mice: direct toxicants or signaling molecules?

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12 December 2020

Role of oxidative stress and antioxidant therapy in alcoholic and nonalcoholic liver diseases.

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12 December 2020

Role of iron in alcoholic liver disease: introduction and summary of the symposium

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12 December 2020

Oxidative damage is increased in human liver tissue adjacent to hepatocellular carcinoma

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12 December 2020

Selective glutathione depletion of mitochondria by ethanol sensitizes hepatocytes to tumor necrosis factor

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12 December 2020

Acidic sphingomyelinase downregulates the liver-specific methionine adenosyltransferase 1A, contributing to tumor necrosis factor-induced lethal hepatitis

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12 December 2020

Polyenylphosphatidylcholine prevents carbon tetrachloride-induced lipid peroxidation while it attenuates liver fibrosis

1 reference

12 December 2020

Oxidative damage and tyrosine nitration from peroxynitrite

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12 December 2020

Idiosyncratic drug hepatotoxicity

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12 December 2020

10.2165/00003495-200565170-00003

Identifiers

DOI

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PubMed ID

16296871

Dimensions Publication ID

13 August 2017

0 references

1 reference

PubMed ID

16296871