Site-specific DNA recombinases as instruments for genomic surgery (Q36314232)

13 August 2017

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title

Site-specific DNA recombinases as instruments for genomic surgery (English)

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13 August 2017

Aram Akopian

1

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PubMed ID

16291210

13 August 2017

W Marshall Stark

series ordinal

2

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13 August 2017

1 January 2005

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13 August 2017

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13 August 2017

55

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13 August 2017

1-23

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Cleavage of the site-specific recombination protein gamma delta resolvase: the smaller of two fragments binds DNA specifically

13 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2805%2955001-6

7 January 2021

Site-specific recombination by mutants of Tn21 resolvase with DNA recognition functions from Tn3 resolvase

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2805%2955001-6

7 January 2021

Chimeric recombinases with designed DNA sequence recognition

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2805%2955001-6

7 January 2021

Mutants of Tn3 resolvase which do not require accessory binding sites for recombination activity

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2805%2955001-6

7 January 2021

DNA binding by mutants of Tn21 resolvase with DNA recognition functions from Tn3 resolvase.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2805%2955001-6

7 January 2021

Genomic targeting with purified Cre recombinase

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2805%2955001-6

7 January 2021

Engineering polydactyl zinc-finger transcription factors

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2805%2955001-6

7 January 2021

Enhancing Gene Targeting with Designed Zinc Finger Nucleases

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2805%2955001-6

7 January 2021

Talking about a Revolution

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2805%2955001-6

7 January 2021

Alteration of Cre recombinase site specificity by substrate-linked protein evolution.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2805%2955001-6

7 January 2021

Activating mutations of Tn3 resolvase marking interfaces important in recombination catalysis and its regulation

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2805%2955001-6

7 January 2021

Targeting survival: integration site selection by retroviruses and LTR-retrotransposons

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2805%2955001-6

7 January 2021

Chimeric restriction enzymes: what is next?

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2805%2955001-6

7 January 2021

Crystal structure of a Flp recombinase-Holliday junction complex: assembly of an active oligomer by helix swapping

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2805%2955001-6

7 January 2021

Engineering proteins that bind, move, make and break DNA.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2805%2955001-6

7 January 2021

Transfer and expression of foreign genes in mammalian cells

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2805%2955001-6

7 January 2021

Identifying determinants of recombination specificity: construction and characterization of mutant bacteriophage integrases

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2805%2955001-6

7 January 2021

Zif268 protein-DNA complex refined at 1.6 A: a model system for understanding zinc finger-DNA interactions

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2805%2955001-6

7 January 2021

A novel engineered meganuclease induces homologous recombination in yeast and mammalian cells

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2805%2955001-6

7 January 2021

Site-specific gene targeting for gene expression in eukaryotes

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2805%2955001-6

7 January 2021

Insertional transposon mutagenesis by electroporation of released Tn5 transposition complexes.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2805%2955001-6

7 January 2021

Analysis of a nucleoprotein complex: the synaptosome of gamma delta resolvase

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2805%2955001-6

7 January 2021

Phage integrases: biology and applications

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2805%2955001-6

7 January 2021

Asymmetric DNA bending in the Cre-loxP site-specific recombination synapse

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2805%2955001-6

7 January 2021

Group II introns designed to insert into therapeutically relevant DNA target sites in human cells

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2805%2955001-6

7 January 2021

Cre mutants with altered DNA binding properties

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2805%2955001-6

7 January 2021

The role of the loxP spacer region in P1 site-specific recombination

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2805%2955001-6

7 January 2021

A mechanism for gene conversion in fungi

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2805%2955001-6

7 January 2021

Highly specific zinc finger proteins obtained by directed domain shuffling and cell-based selection

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2805%2955001-6

7 January 2021

Targeting of retroviral integrase by fusion to a heterologous DNA binding domain: in vitro activities and incorporation of a fusion protein into viral particles

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2805%2955001-6

7 January 2021

Site-specific recombinases: tools for genome engineering.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2805%2955001-6

7 January 2021

Occurrence of leukaemia following gene therapy of X-linked SCID.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2805%2955001-6

7 January 2021

Genome engineering using site-specific recombinases

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2805%2955001-6

7 January 2021

A foreign beta-globin gene in transgenic mice: integration at abnormal chromosomal positions and expression in inappropriate tissues

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2805%2955001-6

7 January 2021

Mobile group II introns

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2805%2955001-6

7 January 2021

Growth inhibition and DNA damage induced by Cre recombinase in mammalian cells

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2805%2955001-6

7 January 2021

AAV vectors: is clinical success on the horizon?

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2805%2955001-6

7 January 2021

Cre recombinase: The universal reagent for genome tailoring

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2805%2955001-6

7 January 2021

Design and selection of novel Cys2His2 zinc finger proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2805%2955001-6

7 January 2021

Germ-line transformation of mice

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2805%2955001-6

7 January 2021

Silencing of gene expression: implications for design of retrovirus vectors

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2805%2955001-6

7 January 2021

Zinc finger-DNA recognition: crystal structure of a Zif268-DNA complex at 2.1 A

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2805%2955001-6

7 January 2021

Target integration by a chimeric Sp1 zinc finger domain-Moloney murine leukemia virus integrase in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2805%2955001-6

7 January 2021

Gene therapy: promises and problems.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2805%2955001-6

7 January 2021

Chimeric nucleases stimulate gene targeting in human cells

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2805%2955001-6

7 January 2021

Repression of the HIV-1 5' LTR promoter and inhibition of HIV-1 replication by using engineered zinc-finger transcription factors

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2805%2955001-6

7 January 2021

Integration by design

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2805%2955001-6

7 January 2021

Directed evolution of the site specificity of Cre recombinase

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2805%2955001-6

7 January 2021

Illegitimate Cre-dependent chromosome rearrangements in transgenic mouse spermatids

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2805%2955001-6

7 January 2021

A DNA-binding domain swap converts the invertase gin into a resolvase

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2805%2955001-6

7 January 2021

Directed evolution of a recombinase for improved genomic integration at a native human sequence

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2805%2955001-6

7 January 2021

Chimeras of the Flp and Cre recombinases: tests of the mode of cleavage by Flp and Cre

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2805%2955001-6

7 January 2021

Theoretical mechanisms in targeted and random integration of transgene DNA.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2805%2955001-6

7 January 2021

Resolvase-catalysed reactions between res sites differing in the central dinucleotide of subsite I

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2805%2955001-6

7 January 2021

DNA shuffling by random fragmentation and reassembly: in vitro recombination for molecular evolution

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2805%2955001-6

7 January 2021

Fusion proteins consisting of human immunodeficiency virus type 1 integrase and the designed polydactyl zinc finger protein E2C direct integration of viral DNA into specific sites

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2805%2955001-6

7 January 2021

Mutational analysis of loxP sites for efficient Cre-mediated insertion into genomic DNA.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2805%2955001-6

7 January 2021

Mammalian genomes contain active recombinase recognition sites

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2805%2955001-6

7 January 2021

Site-specific genomic integration in mammalian cells mediated by phage phiC31 integrase

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2805%2955001-6

7 January 2021

Therapeutic modulation of endogenous gene function by agents with designed DNA-sequence specificities

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2805%2955001-6

7 January 2021

Manipulating the mammalian genome by homologous recombination

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2805%2955001-6

7 January 2021

A dual reporter screening system identifies the amino acid at position 82 in Flp site-specific recombinase as a determinant for target specificity

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2805%2955001-6

7 January 2021

Stepwise manipulation of DNA specificity in Flp recombinase: progressively adapting Flp to individual and combinatorial mutations in its target site

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2805%2955001-6

7 January 2021

Identifying determinants of recombination specificity: construction and characterization of chimeric bacteriophage integrases

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2805%2955001-6

7 January 2021

Therapeutic gene targeting

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2805%2955001-6

7 January 2021

Crystal structure of the site-specific recombinase gamma delta resolvase complexed with a 34 bp cleavage site

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2805%2955001-6

7 January 2021

Controlling integration specificity of a yeast retrotransposon

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2805%2955001-6

7 January 2021

10.1016/S0065-2660(05)55001-6

Identifiers

DOI

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13 August 2017

1 reference

PubMed ID

16291210