Occurrence of leukaemia following gene therapy of X-linked SCID. (Q35166805)

6 August 2017

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title

Occurrence of leukaemia following gene therapy of X-linked SCID. (English)

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6 August 2017

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1

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6 August 2017

Michel Sadelain

2

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PubMed ID

12835668

6 August 2017

Joseph C Glorioso

series ordinal

3

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PubMed ID

12835668

6 August 2017

language of work or name

English

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publication date

1 July 2003

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6 August 2017

Nature Reviews Cancer

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6 August 2017

3

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6 August 2017

477-488

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6 August 2017

7

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https://scigraph.springernature.com/pub.10.1038/nrc1122

6 August 2017

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cites work

Gene therapy for genetic haematological disorders and immunodeficiencies

1 reference

HIV-1 integration in the human genome favors active genes and local hotspots

21 January 2018

1 reference

Site-specific integration by adeno-associated virus

21 January 2018

1 reference

Hematopoietic stem cell gene therapy: towards clinically significant gene transfer efficiency

21 January 2018

1 reference

Gene therapy using hematopoietic stem cells: Sisyphus approaches the crest

21 January 2018

1 reference

Issues in the manufacture and transplantation of genetically modified hematopoietic stem cells

21 January 2018

1 reference

Gene therapy of human severe combined immunodeficiency (SCID)-X1 disease

21 January 2018

1 reference

Sustained correction of X-linked severe combined immunodeficiency by ex vivo gene therapy

21 January 2018

1 reference

Correction of ADA-SCID by stem cell gene therapy combined with nonmyeloablative conditioning

21 January 2018

1 reference

Gene therapy. Second child in French trial is found to have leukemia

21 January 2018

1 reference

Mouse models for multistep tumorigenesis

21 January 2018

1 reference

High-throughput retroviral tagging to identify components of specific signaling pathways in cancer.

21 January 2018

1 reference

Large-scale identification of novel potential disease loci in mouse leukemia applying an improved strategy for cloning common virus integration sites

21 January 2018

1 reference

Retroviral activation of a novel gene encoding a zinc finger protein in IL-3-dependent myeloid leukemia cell lines

21 January 2018

1 reference

Association of erythroid transcription factors: complexes involving the LIM protein RBTN2 and the zinc-finger protein GATA1

21 January 2018

1 reference

Chromosomal translocation master genes, mouse models and experimental therapeutics.

21 January 2018

1 reference

Gene expression signatures define novel oncogenic pathways in T cell acute lymphoblastic leukemia

21 January 2018

1 reference

Defective IL7R expression in T(-)B(+)NK(+) severe combined immunodeficiency

21 January 2018

1 reference

Interleukin-7 mediates the homeostasis of naïve and memory CD8 T cells in vivo

21 January 2018

1 reference

Cytokine control of memory T-cell development and survival

21 January 2018

1 reference

Fatal leukemia in interleukin-15 transgenic mice.

21 January 2018

1 reference

Overexpression of NPM–ALK induces different types of malignant lymphomas in IL-9 transgenic mice

21 January 2018

1 reference

Interleukin 15: biology and relevance to human disease

21 January 2018

1 reference

Interleukin-7 promotes survival and cell cycle progression of T-cell acute lymphoblastic leukemia cells by down-regulating the cyclin-dependent kinase inhibitor p27(kip1).

21 January 2018

1 reference

Serum levels of IL-7 in bone marrow transplant recipients: relationship to clinical characteristics and lymphocyte count

21 January 2018

1 reference

Sturm und drang over suicidal lymphocytes

21 January 2018

1 reference

Cancer immunoediting: from immunosurveillance to tumor escape

21 January 2018

1 reference

IFNgamma and lymphocytes prevent primary tumour development and shape tumour immunogenicity

21 January 2018

1 reference

Biology and adoptive cell therapy of Epstein-Barr virus-associated lymphoproliferative disorders in recipients of marrow allografts.

21 January 2018

1 reference

A review of Epstein-Barr virus infection in patients with immunodeficiency disorders

21 January 2018

1 reference

New aspects of natural-killer-cell surveillance and therapy of cancer

21 January 2018

1 reference

A rapid RT-PCR based method to isolate complementary DNA fragments flanking retrovirus integration sites

21 January 2018

1 reference

Detection and direct genomic sequencing of multiple rare unknown flanking DNA in highly complex samples

21 January 2018

1 reference

Helper virus induced T cell lymphoma in nonhuman primates after retroviral mediated gene transfer

21 January 2018

1 reference

Self-inactivating retroviral vectors designed for transfer of whole genes into mammalian cells

21 January 2018

1 reference

Use of intron-disrupted polyadenylation sites to enhance expression and safety of retroviral vectors

21 January 2018

1 reference

RNA 3' readthrough of oncoretrovirus and lentivirus: implications for vector safety and efficacy

21 January 2018

1 reference

Globin gene transfer for the treatment of severe hemoglobinopathies: a paradigm for stem cell-based gene therapy

21 January 2018

1 reference

Therapeutic haemoglobin synthesis in beta-thalassaemic mice expressing lentivirus-encoded human beta-globin

21 January 2018

1 reference

Tetracycline-controlled transcription in eukaryotes: novel transactivators with graded transactivation potential

21 January 2018

1 reference

Chromatin insulators and boundaries: effects on transcription and nuclear organization

21 January 2018

1 reference

Insulators: many functions, many mechanisms.

21 January 2018

1 reference

The cHS4 insulator increases the probability of retroviral expression at random chromosomal integration sites.

21 January 2018

1 reference

A chromatin insulator protects retrovirus vectors from chromosomal position effects

21 January 2018

1 reference

Suicide gene-mediated modulation of graft-versus-host disease

21 January 2018

1 reference

Naturally occurring primary deficiencies of the immune system

21 January 2018

1 reference

The molecular basis of X-linked severe combined immunodeficiency: defective cytokine receptor signaling

21 January 2018

1 reference

Interleukin-2 receptor gamma chain mutation results in X-linked severe combined immunodeficiency in humans

21 January 2018

1 reference

Close linkage of the locus for X chromosome-linked severe combined immunodeficiency to polymorphic DNA markers in Xq11-q13.

21 January 2018

1 reference

Sharing of the interleukin-2 (IL-2) receptor gamma chain between receptors for IL-2 and IL-4

21 January 2018

1 reference

Interleukin-2 receptor gamma chain: a functional component of the interleukin-4 receptor

21 January 2018

1 reference

Interleukin-2 receptor gamma chain: a functional component of the interleukin-7 receptor

21 January 2018

1 reference

Functional participation of the IL-2 receptor gamma chain in IL-7 receptor complexes

21 January 2018

1 reference

Interaction of IL-2R beta and gamma c chains with Jak1 and Jak3: implications for XSCID and XCID

21 January 2018

1 reference

Sharing of the IL-2 receptor gamma chain with the functional IL-9 receptor complex

21 January 2018

1 reference

Cutting edge: the common gamma-chain is an indispensable subunit of the IL-21 receptor complex

21 January 2018

1 reference

Cytokines and immunodeficiency diseases

21 January 2018

1 reference

Reversible defects in natural killer and memory CD8 T cell lineages in interleukin 15-deficient mice

21 January 2018

1 reference

Mutations of Jak-3 gene in patients with autosomal severe combined immune deficiency (SCID)

21 January 2018

1 reference

Mutation of Jak3 in a patient with SCID: essential role of Jak3 in lymphoid development.

21 January 2018

1 reference

Molecular themes in oncogenesis

21 January 2018

1 reference

Potential leukemic cells among bone marrow cells of young AKR/J mice

21 January 2018

1 reference

Long-distance activation of the Myc protooncogene by provirus insertion in Mlvi-1 or Mlvi-4 in rat T-cell lymphomas

21 January 2018

1 reference

Retroviral insertions 90 kilobases proximal to the Evi-1 myeloid transforming gene activate transcription from the normal promoter

21 January 2018

1 reference

Murine T lymphomas in which the cellular myc oncogene has been activated by retroviral insertion.

21 January 2018

1 reference

Long-term survival and transplantation of haemopoietic stem cells for immunodeficiencies: report of the European experience 1968–99

21 January 2018

1 reference

AAV serotype 2 vectors preferentially integrate into active genes in mice

21 January 2018

1 reference

Durability of transgene expression and vector integration: recombinant SV40-derived gene therapy vectors

31 March 2020

1 reference

New genes involved in cancer identified by retroviral tagging

31 March 2020

1 reference

Murine leukemia induced by retroviral gene marking

31 March 2020

1 reference

Safety of retroviral gene marking with a truncated NGF receptor

31 March 2020

1 reference

Yeast retrotransposons: finding a nice quiet neighborhood

31 March 2020

1 reference

Human severe combined immunodeficiency: genetic, phenotypic, and functional diversity in one hundred eight infants

31 March 2020

1 reference

IL-15 receptor maintains lymphoid homeostasis by supporting lymphocyte homing and proliferation

31 March 2020

1 reference

31 March 2020

Identifiers

DOI

10.1038/NRC1122

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6 August 2017

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PubMed ID

12835668