Induction of stable RNA interference in mammalian cells (Q36272950)

13 August 2017

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title

Induction of stable RNA interference in mammalian cells (English)

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13 August 2017

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Bryan R Cullen

1

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13 August 2017

1 March 2006

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13 August 2017

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13 August 2017

13

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13 August 2017

503-508

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13 August 2017

6

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https://scigraph.springernature.com/pub.10.1038/sj.gt.3302656

13 August 2017

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Short hairpin RNAs (shRNAs) induce sequence-specific silencing in mammalian cells

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A system for stable expression of short interfering RNAs in mammalian cells

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Role for a bidentate ribonuclease in the initiation step of RNA interference

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Human Dicer preferentially cleaves dsRNAs at their termini without a requirement for ATP

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Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

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An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells

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Evidence that siRNAs function as guides, not primers, in the Drosophila and human RNAi pathways.

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Single-stranded antisense siRNAs guide target RNA cleavage in RNAi

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Argonaute2 is the catalytic engine of mammalian RNAi

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Human Argonaute2 mediates RNA cleavage targeted by miRNAs and siRNAs

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siRNAs can function as miRNAs

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MicroRNAs and small interfering RNAs can inhibit mRNA expression by similar mechanisms

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A microRNA in a multiple-turnover RNAi enzyme complex

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Identification of novel genes coding for small expressed RNAs

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Human microRNAs are processed from capped, polyadenylated transcripts that can also function as mRNAs

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MicroRNA genes are transcribed by RNA polymerase II

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The nuclear RNase III Drosha initiates microRNA processing

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The Drosha-DGCR8 complex in primary microRNA processing

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The Microprocessor complex mediates the genesis of microRNAs

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Processing of primary microRNAs by the Microprocessor complex

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Nuclear export of microRNA precursors

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Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs

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Recognition and cleavage of primary microRNA precursors by the nuclear processing enzyme Drosha

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Functional siRNAs and miRNAs Exhibit Strand Bias

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Asymmetry in the assembly of the RNAi enzyme complex

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Both natural and designed micro RNAs can inhibit the expression of cognate mRNAs when expressed in human cells

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Enhanced gene silencing of HIV-1 specific siRNA using microRNA designed hairpins

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Structural requirements for pre-microRNA binding and nuclear export by Exportin 5.

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Interactions between double-stranded RNA regulators and the protein kinase DAI

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Rational siRNA design for RNA interference

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Local RNA target structure influences siRNA efficacy: a systematic global analysis

21 January 2018

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HIV-1 can escape from RNA interference by evolving an alternative structure in its RNA genome

21 January 2018

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A statistical sampling algorithm for RNA secondary structure prediction

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Sfold web server for statistical folding and rational design of nucleic acids

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RNA interference in human cells is restricted to the cytoplasm

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Specific and potent RNAi in the nucleus of human cells

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Retroviral delivery of small interfering RNA into primary cells

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Stable suppression of tumorigenicity by virus-mediated RNA interference

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Inhibition of human immunodeficiency virus type 1 replication in primary macrophages by using Tat- or CCR5-specific small interfering RNAs expressed from a lentivirus vector

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A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interference

21 January 2018

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A general method for gene knockdown in mice by using lentiviral vectors expressing small interfering RNA.

21 January 2018

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Induction of an interferon response by RNAi vectors in mammalian cells

21 January 2018

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Target accessibility dictates the potency of human RISC

21 January 2018

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inferred from DOI database lookup

7 January 2021

based on heuristic

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302656

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/SJ.GT.3302656

1 reference

13 August 2017

1 reference

PubMed ID

16195700