HNF4α antagonists discovered by a high-throughput screen for modulators of the human insulin promoter (Q36249040)

13 August 2017

HNF4α antagonists discovered by a high-throughput screen for modulators of the human insulin promoter (English)

1 reference

13 August 2017

1 reference

Benjamin Spangler

14

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Adam D Richardson

Adam D Richardson

10

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Layton H. Smith

Layton Smith

15

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Anthony B Pinkerton

Anthony B Pinkerton

7

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Fred Levine

Fred Levine

24

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Hudson H. Freeze

Hudson Freeze

18

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author name string

Alice Kiselyuk

1

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13 August 2017

Seung-Hee Lee

2

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13 August 2017

Suzette Farber-Katz

3

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13 August 2017

Mingjun Zhang

4

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13 August 2017

Sonalee Athavankar

5

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13 August 2017

Tom Cohen

6

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13 August 2017

Mao Ye

8

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13 August 2017

Paul Bushway

9

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13 August 2017

Heather A Hostetler

11

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13 August 2017

Mariam Rodriguez-Lee

12

1 reference

13 August 2017

Li Huang

13

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13 August 2017

Jennifer Higginbotham

16

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13 August 2017

John Cashman

17

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13 August 2017

Pamela Itkin-Ansari

19

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13 August 2017

Marcia I Dawson

20

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13 August 2017

Friedhelm Schroeder

21

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13 August 2017

Yong Cang

22

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13 August 2017

Mark Mercola

23

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13 August 2017

1 July 2012

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13 August 2017

Chemistry and Biology

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13 August 2017

19

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13 August 2017

7

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13 August 2017

806-818

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describes a project that uses

13 August 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3447631/fullTextXML

inferred from PubMed Central ID database lookup

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Expansion of adult beta-cell mass in response to increased metabolic demand is dependent on HNF-4alpha

1 October 2017

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1 October 2017

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Thioesterase activity and acyl-CoA/fatty acid cross-talk of hepatocyte nuclear factor-4{alpha}

1 October 2017

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The MODY1 gene HNF-4alpha regulates selected genes involved in insulin secretion

1 October 2017

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Systematic discovery of regulatory motifs in human promoters and 3' UTRs by comparison of several mammals

1 October 2017

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Control of pancreas and liver gene expression by HNF transcription factors

1 October 2017

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Structural basis for HNF-4alpha activation by ligand and coactivator binding

1 October 2017

1 reference

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Expression and localization of P1 promoter-driven hepatocyte nuclear factor-4alpha (HNF4alpha) isoforms in human and rats

1 October 2017

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Hepatocyte nuclear factor 4 is a transcription factor that constitutively binds fatty acids

1 October 2017

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Crystal structure of the HNF4 alpha ligand binding domain in complex with endogenous fatty acid ligand

1 October 2017

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Defective ureagenesis in mice carrying a liver-specific disruption of hepatocyte nuclear factor 4alpha (HNF4alpha ). HNF4alpha regulates ornithine transcarbamylase in vivo

1 October 2017

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1 October 2017

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Nuclear receptor coregulators: multiple modes of modification

1 October 2017

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An enhancer element 6 kb upstream of the mouse HNF4alpha1 promoter is activated by glucocorticoids and liver-enriched transcription factors

1 October 2017

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Expression profiling suggested a regulatory role of liver-enriched transcription factors in human hepatocellular carcinoma.

1 October 2017

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Hepatocyte nuclear factor 4alpha (nuclear receptor 2A1) is essential for maintenance of hepatic gene expression and lipid homeostasis

1 October 2017

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The peroxisome proliferator response element (PPRE) present at positions -681/-669 in the rat liver 3-ketoacyl-CoA thiolase B gene functionally interacts differently with PPARalpha and HNF-4.

1 October 2017

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Human insulin gene is a target gene of hepatocyte nuclear factor-1alpha (HNF-1alpha) and HNF-1beta

1 October 2017

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1 October 2017

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The maturity-onset diabetes of the young (MODY1) transcription factor HNF4alpha regulates expression of genes required for glucose transport and metabolism

1 October 2017

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1 October 2017

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Murine gastrulation requires HNF-4 regulated gene expression in the visceral endoderm: tetraploid rescue of Hnf-4(-/-) embryos

1 October 2017

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1 October 2017

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1 October 2017

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Disruption of the HNF-4 gene, expressed in visceral endoderm, leads to cell death in embryonic ectoderm and impaired gastrulation of mouse embryos

1 October 2017

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Derivation of a retinoid X receptor scaffold from peroxisome proliferator-activated receptor gamma ligand 1-Di(1H-indol-3-yl)methyl-4-trifluoromethylbenzene

1 October 2017

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Hepatocyte nuclear factor-4 activates medium chain acyl-CoA dehydrogenase gene transcription by interacting with a complex regulatory element.

29 June 2018

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29 June 2018

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Target identification using drug affinity responsive target stability (DARTS)

29 June 2018

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Drosophila HNF4 regulates lipid mobilization and beta-oxidation

22 September 2018

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Inhibition of colorectal cancer by targeting hepatocyte nuclear factor-4alpha

22 September 2018

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Beta-cell differentiation from nonendocrine epithelial cells of the adult human pancreas.

22 September 2018

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FK614, a novel peroxisome proliferator-activated receptor gamma modulator, induces differential transactivation through a unique ligand-specific interaction with transcriptional coactivators

22 September 2018

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Stability of fatty acyl-coenzyme A thioester ligands of hepatocyte nuclear factor-4alpha and peroxisome proliferator-activated receptor-alpha

22 September 2018

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22 September 2018

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A novel orthotopic tumor model to study growth factors and oncogenes in hepatocarcinogenesis.

22 September 2018

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Suppression of hepatocyte nuclear factor-4alpha by acyl-CoA thioesters of hypolipidemic peroxisome proliferators

22 September 2018

1 reference

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Analysis of protein dimerization and ligand binding of orphan receptor HNF4alpha

22 September 2018

1 reference

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Transactivation of the peroxisome proliferator-activated receptor is differentially modulated by hepatocyte nuclear factor-4

22 September 2018

1 reference

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Phenotypic screening of hepatocyte nuclear factor (HNF) 4-gamma receptor knockout mice

5 December 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22840769

12 December 2020

inferred from PubMed ID database lookup

Activation of the insulin gene promoter through a direct effect of hepatocyte nuclear factor 4 alpha

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22840769

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1016/J.CHEMBIOL.2012.05.014

1 reference

release_nmq33wt67nbw5owpe3etn7qzai

13 August 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/nmq33wt67nbw5owpe3etn7qzai

24 November 2022

mapped directly with Wikidata item

1 reference

13 August 2017

1 reference