Microdialysis: current applications in clinical pharmacokinetic studies and its potential role in the future (Q36240743)

13 August 2017

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title

Microdialysis: current applications in clinical pharmacokinetic studies and its potential role in the future (English)

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13 August 2017

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Christian Joukhadar

1

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PubMed ID

16122279

13 August 2017

Markus Müller

series ordinal

2

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13 August 2017

1 January 2005

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Clinical Pharmacokinetics

13 August 2017

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13 August 2017

44

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13 August 2017

895-913

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13 August 2017

9

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https://scigraph.springernature.com/pub.10.2165/00003088-200544090-00002

13 August 2017

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Penetration of antibiotics into respiratory secretions.

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Clinical efficacy and levels of ciprofloxacin in tissue in patients with soft tissue infection

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Changes in skin circulation after insertion of a microdialysis probe visualized by laser Doppler perfusion imaging

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Effects of local blood flow on the percutaneous absorption of the organophosphorus compound malathion: a microdialysis study in man.

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A combined in vivo pharmacokinetic-in vitro pharmacodynamic approach to simulate target site pharmacodynamics of antibiotics in humans

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Paracrine effects of angiotensin-converting-enzyme- and angiotensin-II-receptor- inhibition on transcapillary glucose transport in humans

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Relevance of soft-tissue penetration by levofloxacin for target site bacterial killing in patients with sepsis

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12 December 2020

In situ microdialysis in bone tissue. Stimulation of prostaglandin E2 release by weight-bearing mechanical loading

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12 December 2020

Human lung tumors: SPECT quantitation of differences in Co-57 bleomycin uptake

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12 December 2020

The penetration of anti-infectives into the central nervous system

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12 December 2020

Cefodizime in skin suction blister fluid and serum following a single intravenous or intramuscular dose in adult patients

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12 December 2020

In vivo tissue pharmacokinetics by fluorine magnetic resonance spectroscopy: a study of liver and muscle disposition of fleroxacin in humans

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12 December 2020

Pharmacokinetics of newer cephalosporins after subconjunctival and intravitreal injection in rabbits

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12 December 2020

Penetration of ciprofloxacin into the interstitial space of inflamed foot lesions in non-insulin-dependent diabetes mellitus patients

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12 December 2020

Extracellular amino acids as markers of myocardial ischemia during cardioplegic heart arrest

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12 December 2020

Rifampin concentrations in various compartments of the human brain: a novel method for determining drug levels in the cerebral extracellular space

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12 December 2020

Pharmacodynamics of piperacillin in severely ill patients evaluated by using a PK/PD model.

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12 December 2020

Microdialysis of Lipophilic Compounds: A Methodological Study

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12 December 2020

The role of stratum corneum and dermal microvascular perfusion in penetration and tissue levels of water-soluble drugs investigated by microdialysis

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12 December 2020

Distribution and antimicrobial activity of fosfomycin in the interstitial fluid of human soft tissues.

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12 December 2020

Prospective study of preincisional single-dose ceftriaxone in reducing postoperative wound infection in high risk of infection patients

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12 December 2020

Closed-chest microdialysis to measure antibiotic penetration into human lung tissue

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12 December 2020

Regulation of the hepatic multidrug resistance gene expression by endotoxin and inflammatory cytokines in mice.

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12 December 2020

Effect of barrier perturbation on cutaneous penetration of salicylic acid in hairless rats: in vivo pharmacokinetics using microdialysis and non-invasive quantification of barrier function

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12 December 2020

Micellar electrokinetic chromatography for the analysis of cefpirome in microdialysis and plasma samples obtained in vivo from human volunteers

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12 December 2020

Microdialysis sampling coupled to HPLC for transdermal delivery study of ondansetron hydrochloride in rats

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12 December 2020

The importance of pharmacokinetic/pharmacodynamic surrogate markers to outcome. Focus on antibacterial agents

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12 December 2020

Pharmacokinetics and tissue penetration of Timentin: a simultaneous study of serum, urine, lymph, suction blister and subcutaneous thread fluid

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12 December 2020

Determination of brain interstitial concentrations by microdialysis.

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12 December 2020

Application of microdialysis to clinical pharmacokinetics in humans

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12 December 2020

Anatomical barriers for antimicrobial agents

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12 December 2020

The use of intracerebral microdialysis for the determination of pharmacokinetic profiles of anticancer drugs in tumor-bearing rat brain

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12 December 2020

Surgery and intensive care procedures affect the target site distribution of piperacillin

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12 December 2020

Evaluation of in-vivo transdermal absorption of cyclosporin with absorption enhancer using intradermal microdialysis in rats

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12 December 2020

Intratumoral differences in methotrexate levels within human osteosarcoma xenografts studied by microdialysis

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12 December 2020

Ciprofloxacin concentrations in lung tissue following a single 400 mg intravenous dose

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12 December 2020

Extracellular levels of taurine in tumoral, peritumoral and normal brain tissue in patients with malignant glioma: an intraoperative microdialysis study

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12 December 2020

Evaluation of transdermal iontophoresis of enoxacin from polymer formulations: in vitro skin permeation and in vivo microdialysis using Wistar rat as an animal model

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12 December 2020

Penetration of linezolid into soft tissues of healthy volunteers after single and multiple doses.

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12 December 2020

Drug distribution studies with microdialysis. III: Extracellular concentration of caffeine in adipose tissue in man

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12 December 2020

Gentamicin concentrations in human subcutaneous tissue

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12 December 2020

Dermal pharmacokinetics of microemulsion formulations determined by in vivo microdialysis

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12 December 2020

Lipo-microdialysis: a new microdialysis method for studying the pharmacokinetics of lipophilic substances

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12 December 2020

Interface-area-to-volume ratio of interstitial fluid in humans determined by pharmacokinetic analysis of netilmicin in small and large skin blisters

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12 December 2020

Interstitial tissue concentrations of cefpodoxime

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12 December 2020

Intradermal microdialysis: kinetics of iontophoretically delivered propranolol in forearm dermis

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12 December 2020

Time course of 8-methoxypsoralen concentrations in skin and plasma after topical (bath and cream) and oral administration of 8-methoxypsoralen

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12 December 2020

Target site bacterial killing of cefpirome and fosfomycin in critically ill patients

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12 December 2020

Pharmacokinetics of antibiotics in natural and experimental superficial compartments in animals and humans

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12 December 2020

Potentiation of cytotoxic cancer therapies by TNP-470 alone and with other anti-angiogenic agents

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12 December 2020

Measurement of pulmonary erythromycin concentration in patients with lobar pneumonia by means of positron tomography

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12 December 2020

Effect of the p-glycoprotein inhibitor, cyclosporin A, on the distribution of rhodamine-123 to the brain: an in vivo microdialysis study in freely moving rats

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12 December 2020

Microdialysis in the study of extracellular levels of amino acids in the rat brain.

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12 December 2020

Microdialysis and response during regional chemotherapy by isolated limb infusion of melphalan for limb malignancies

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12 December 2020

Bioequivalence of topical dermatological dosage forms--methods of evaluation of bioequivalence

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12 December 2020

Dermal microdialysis sampling in vivo

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12 December 2020

Dialytrode for long term intracerebral perfusion in awake monkeys

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12 December 2020

Pharmacokinetics of [18F]fleroxacin in healthy human subjects studied by using positron emission tomography

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12 December 2020

Measurement of extracellular fluid carboplatin kinetics in melanoma metastases with microdialysis

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12 December 2020

Cutaneous microdialysis for the measurement in vivo of the percutaneous absorption of organic solvents

1 reference

12 December 2020

Muscle blood flow in cats: comparison of microdialysis ethanol technique with direct measurement

1 reference

12 December 2020

Development of a liquid chromatography method for the determination of linezolid and its application to in vitro and human microdialysis samples

1 reference

12 December 2020

In-vivo microdialysis study of the distribution of cisplatin into brain tumour tissue after intracarotid infusion in rats with 9L malignant glioma.

1 reference

12 December 2020

Pharmacokinetics and burn eschar penetration of intravenous ciprofloxacin in patients with major thermal injuries

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12 December 2020

Tumor seeding occurring after fine-needle biopsy of abdominal malignancies

1 reference

12 December 2020

Effect of barrier perturbation on cutaneous salicylic acid penetration in human skin: in vivo pharmacokinetics using microdialysis and non-invasive quantification of barrier function

1 reference

12 December 2020

Vascular channel formation by human melanoma cells in vivo and in vitro: vasculogenic mimicry

1 reference

12 December 2020

Effect of transdermal iontophoresis codelivery of hydrocortisone on metoclopramide pharmacokinetics and skin-induced reactions in human subjects

1 reference

12 December 2020

General principles of antibiotic tissue penetration

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12 December 2020

Continuous intratumoral microdialysis during high-dose methotrexate therapy in a patient with malignant fibrous histiocytoma of the femur: a case report

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12 December 2020

Delivery of molecular medicine to solid tumors

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12 December 2020

Feasibility of measuring lipophilic or protein-bound drugs in the dermis by in vivo microdialysis after topical or systemic drug administration.

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12 December 2020

Ethanol absorption across human skin measured by in vivo microdialysis technique

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12 December 2020

Metastases caused by fine needle puncture?

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12 December 2020

5-fluorouracil kinetics in the interstitial tumor space: clinical response in breast cancer patients

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12 December 2020

Penetration of Moxifloxacin into Healthy and Inflamed Subcutaneous Adipose Tissues in Humans

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12 December 2020

Microdialysis sampling in tumor and muscle: study of the disposition of 3-amino-1,2,4-benzotriazine-1,4-di-N-oxide (SR 4233)

1 reference

12 December 2020

Effect of P-glycoprotein modulators on the pharmacokinetics of camptothecin using microdialysis

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12 December 2020

Pharmacodynamic-mediated reduction of temozolomide tumor concentrations by the angiogenesis inhibitor TNP-470.

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12 December 2020

Transcapillary insulin transfer in human skeletal muscle

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12 December 2020

Filtration coefficients and osmotic reflexion coefficients of the walls of single frog mesenteric capillaries

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12 December 2020

The synthesis of fluorine-18 lomefloxacin and its preliminary use in human studies

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12 December 2020

Substantial elevation of interleukin-6 concentration in peritendinous tissue, in contrast to muscle, following prolonged exercise in humans

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12 December 2020

Target site concentrations of ciprofloxacin after single intravenous and oral doses

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12 December 2020

In vivo evidence for ATP-dependent and P-glycoprotein-mediated transport of cyclosporin A at the blood-brain barrier

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12 December 2020

Rational dosing of antibiotics: the use of plasma concentrations versus tissue concentrations

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12 December 2020

Distribution to the skin of penciclovir after oral famciclovir administration in healthy volunteers: comparison of the suction blister technique and cutaneous microdialysis

1 reference

12 December 2020

Iontophoretic current and intradermal microdialysis recovery in humans

1 reference

12 December 2020

In vivo microdialysis for the transdermal absorption of valproate in rats

1 reference

12 December 2020

Pharmacokinetic/pharmacodynamic studies in drug product development

1 reference

12 December 2020

The transplacental transfer of the macrolide antibiotics erythromycin, roxithromycin and azithromycin

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12 December 2020

Validation of urea as an endogenous reference compound for the in vivo calibration of microdialysis probes

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12 December 2020

Transport of molecules in the tumor interstitium: a review

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12 December 2020

Microdialysis--a new and promising method in clinical medicine

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12 December 2020

Application of microdialysis for the determination of muscle and subcutaneous tissue concentrations after oral and topical ibuprofen administration

1 reference

12 December 2020

Considerations in the use of cerebrospinal fluid pharmacokinetics to predict brain target concentrations in the clinical setting: implications of the barriers between blood and brain.

1 reference

12 December 2020

Ocular penetration of ceftriaxone, ceftazidime, and vancomycin after subconjunctival injection in humans

1 reference

12 December 2020

Prostatitis: Man's hidden infection

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12 December 2020

PET: the merging of biology and imaging into molecular imaging.

1 reference

12 December 2020

Penetration of fosfomycin into inflammatory lesions in patients with cellulitis or diabetic foot syndrome

1 reference

12 December 2020

Distribution and antimicrobial activity of ciprofloxacin in human soft tissues

1 reference

12 December 2020

Interstitial methotrexate kinetics in primary breast cancer lesions.

1 reference

12 December 2020

Tobramycin serum levels and tissue content in children

1 reference

12 December 2020

Characterization of peripheral-compartment kinetics of antibiotics by in vivo microdialysis in humans

1 reference

12 December 2020

Plasma and tissue pharmacokinetics of cefpirome in patients with sepsis

1 reference

12 December 2020

Experimental models for studies on transportation of antibiotics to extravasal compartments

1 reference

12 December 2020

Impaired target site penetration of beta-lactams may account for therapeutic failure in patients with septic shock

1 reference

12 December 2020

In vivo microdialysis for the investigation of drug levels in the dermis and the effect of barrier perturbation on cutaneous drug penetration. Studies in hairless rats and human subjects.

1 reference

12 December 2020

Target site penetration of fosfomycin in critically ill patients

1 reference

12 December 2020

Extracellular glutamate and other metabolites in and around RG2 rat glioma: an intracerebral microdialysis study.

1 reference

12 December 2020

Studies on the pharmacokinetics of cefoxitin, cefuroxime, cephaloridine and cephalothin using subcutaneous tissue cages

1 reference

12 December 2020

Transdermal iontophoretic delivery of diclofenac sodium from various polymer formulations: in vitro and in vivo studies.

1 reference

12 December 2020

A microdialysis method allowing characterization of intercellular water space in humans

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12 December 2020

Effects of blood flow on the in vivo recovery of a small diffusible molecule by microdialysis in human skin

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12 December 2020

Target site concentrations after continuous infusion and bolus injection of cefpirome to healthy volunteers

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12 December 2020

Intra- and peri-tendinous microdialysis determination of glucose and lactate in pigs

1 reference

12 December 2020

Relationship between in vivo drug exposure of the tumor interstitium and inhibition of tumor cell growth in vitro: a study in breast cancer patients

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12 December 2020

Application of the minimal trauma tissue biopsy to transdermal clinical pharmacokinetic studies

1 reference

12 December 2020

Measurement of cyclooxygenase inhibition in vivo: a study of two non-steroidal anti-inflammatory drugs in sheep.

1 reference

12 December 2020

In vivo study of tumor metabolism: an application of new multi-probe microdialysis system in the striatum of freely moving rats grafted with C6 cells

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12 December 2020

Tissue distribution of imipenem in critically ill patients

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12 December 2020

Assessment of drug disposition in the lung

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12 December 2020

Penetration of fosfomycin into the parenchyma of human brain: a case study in three patients

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12 December 2020

Topical delivery of keloid therapeutic drug, tranilast, by combined use of oleic acid and propylene glycol as a penetration enhancer: evaluation by skin microdialysis in rats

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12 December 2020

Evaluation of technetium-99m ciprofloxacin (Infecton) in the imaging of infection.

1 reference

12 December 2020

Penetration of capecitabine and its metabolites into malignant and healthy tissues of patients with advanced breast cancer

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12 December 2020

Suction-induced blister fluid penetration of cefdinir in healthy volunteers following ascending oral doses

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12 December 2020

The role of positron emission tomography in pharmacokinetic analysis

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12 December 2020

Pharmacokinetics of 18F-labeled fluconazole in healthy human subjects by positron emission tomography

1 reference

12 December 2020

Penetration of dacarbazine and its active metabolite 5-aminoimidazole-4-carboxamide into cutaneous metastases of human malignant melanoma.

1 reference

12 December 2020

Penetration of telithromycin (HMR 3647), a new ketolide antimicrobial, into inflammatory blister fluid following oral administration

1 reference

12 December 2020

Effects of Different Semipermeable Membranes on In Vitro and In Vivo Performance of Microdialysis Probes

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12 December 2020

Determinants of capillary permeability: a review of mechanisms based on single capillary studies in the frog

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12 December 2020

Tissue chamber model of acute inflammation in farm animal species

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12 December 2020

Pharmacokinetics of telithromycin in plasma and soft tissues after single-dose administration to healthy volunteers.

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12 December 2020

Macrolide-resistant group a streptococcus--now in the United States.

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12 December 2020

Soft tissue concentrations of ciprofloxacin in obese and lean subjects following weight-adjusted dosing

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12 December 2020

Delta-aminolevulinic acid in superficial basal cell carcinomas and normal skin-a microdialysis and perfusion study

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12 December 2020

Clinical significance of tissue penetration of antibiotics in the respiratory tract

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12 December 2020

P-glycoprotein and multidrug resistance-associated protein are involved in the regulation of extracellular levels of the major antiepileptic drug carbamazepine in the brain

1 reference

12 December 2020

Successful management of discovered pH dependence in vancomycin recovery studies: novel HPLC method for microdialysis and plasma samples

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12 December 2020

Regulation of the multidrug resistance genes by stress signals

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12 December 2020

Diclofenac concentrations in defined tissue layers after topical administration

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12 December 2020

Multiple pathways of capillary permeability

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12 December 2020

Microdialysis technique as a method to study the percutaneous penetration of methyl nicotinate through excised human skin, reconstructed epidermis, and human skin in vivo

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12 December 2020

Association of intratumoral pharmacokinetics of fluorouracil with clinical response

1 reference

12 December 2020

Angioplasty increases target site concentrations of ciprofloxacin in patients with peripheral arterial occlusive disease

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12 December 2020

Comparative target site pharmacokinetics of immediate- and modified-release formulations of cefaclor in humans

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12 December 2020

Kinetics of tissue penetration. Are high plasma peak concentrations or sustained levels preferable for effective antibiotic therapy?

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12 December 2020

Microdialysis in cutaneous pharmacology: kinetic analysis of transdermally delivered nicotine.

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12 December 2020

Application of in vivo microdialysis to transdermal absorption of methotrexate in rats

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12 December 2020

Transdermal penetration of diclofenac after multiple epicutaneous administration

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12 December 2020

Antiangiogenic treatment (TNP-470/minocycline) increases tissue levels of anticancer drugs in mice bearing Lewis lung carcinoma

1 reference

12 December 2020

10.2165/00003088-200544090-00002

Identifiers

DOI

1 reference

PubMed ID

16122279

Dimensions Publication ID

13 August 2017

0 references

1 reference

PubMed ID

16122279