Ex vivo interleukin-12-priming during CD8(+) T cell activation dramatically improves adoptive T cell transfer antitumor efficacy in a lymphodepleted host. (Q36193963)

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English	Ex vivo interleukin-12-priming during CD8(+) T cell activation dramatically improves adoptive T cell transfer antitumor efficacy in a lymphodepleted host.	scientific article

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23 January 2020

Ex vivo interleukin-12-priming during CD8(+) T cell activation dramatically improves adoptive T cell transfer antitumor efficacy in a lymphodepleted host (English)

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23 January 2020

Mohamed L. Salem

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23 January 2020

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Mark P Rubinstein

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23 January 2020

Colleen A Cloud

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23 January 2020

Tracy E Garrett

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23 January 2020

Caitlin J Moore

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23 January 2020

Kristina M Schwartz

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23 January 2020

C Bryce Johnson

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23 January 2020

David H Craig

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23 January 2020

Chrystal M Paulos

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23 January 2020

David J Cole

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23 January 2020

publication date

22 February 2012

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23 January 2020

Journal of the American College of Surgeons

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23 January 2020

214

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23 January 2020

4

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23 January 2020

700-7; discussion 707-8

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23 January 2020

T cells with chimeric antigen receptors have potent antitumor effects and can establish memory in patients with advanced leukemia

1 reference

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1 October 2017

Enhanced sensitivity to IL-2 signaling regulates the clinical responsiveness of IL-12-primed CD8(+) T cells in a melanoma model

1 reference

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1 October 2017

Dendritic cell recovery post-lymphodepletion: a potential mechanism for anti-cancer adoptive T cell therapy and vaccination

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1 October 2017

Gene regulation and chromatin remodeling by IL-12 and type I IFN in programming for CD8 T cell effector function and memory

1 reference

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1 October 2017

Type 17 CD8+ T cells display enhanced antitumor immunity.

1 reference

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1 October 2017

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Recovery from cyclophosphamide-induced lymphopenia results in expansion of immature dendritic cells which can mediate enhanced prime-boost vaccination antitumor responses in vivo when stimulated with the TLR3 agonist poly(I:C)

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1 October 2017

IL-7 and IL-15 differentially regulate CD8+ T-cell subsets during contraction of the immune response

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1 October 2017

Memory T cells in cancer immunotherapy: which CD8 T-cell population provides the best protection against tumours?

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1 October 2017

Adoptive cell transfer: a clinical path to effective cancer immunotherapy

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1 October 2017

Adoptive transfer of effector CD8+ T cells derived from central memory cells establishes persistent T cell memory in primates

1 reference

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1 October 2017

Priming of naive CD8+ T cells in the presence of IL-12 selectively enhances the survival of CD8+CD62Lhi cells and results in superior anti-tumor activity in a tolerogenic murine model.

1 reference

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1 October 2017

Adoptive T cell therapy for cancer in the clinic

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1 October 2017

Principles of adoptive T cell cancer therapy

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1 October 2017

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1 October 2017

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1 October 2017

Telomere length of transferred lymphocytes correlates with in vivo persistence and tumor regression in melanoma patients receiving cell transfer therapy.

1 reference

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1 October 2017

Signal 3 tolerant CD8 T cells degranulate in response to antigen but lack granzyme B to mediate cytolysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3429131

1 October 2017

Central memory self/tumor-reactive CD8+ T cells confer superior antitumor immunity compared with effector memory T cells

1 reference

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1 October 2017

Acquisition of full effector function in vitro paradoxically impairs the in vivo antitumor efficacy of adoptively transferred CD8+ T cells

1 reference

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1 October 2017

Toward improved immunocompetence of adoptively transferred CD8+ T cells

1 reference

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1 October 2017

Adoptive cell transfer therapy following non-myeloablative but lymphodepleting chemotherapy for the treatment of patients with refractory metastatic melanoma

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Tumor regression and autoimmunity after reversal of a functionally tolerant state of self-reactive CD8+ T cells.

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1 October 2017

Signal 3 determines tolerance versus full activation of naive CD8 T cells: dissociating proliferation and development of effector function

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1 October 2017

The roles of IL-12 in providing a third signal for clonal expansion of naive CD8 T cells

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1 October 2017

Systemic administration of IL-15 augments the antigen-specific primary CD8+ T cell response following vaccination with peptide-pulsed dendritic cells.

1 reference

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10.1016/J.JAMCOLLSURG.2011.12.034

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23 January 2020

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23 January 2020

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23 January 2020

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