Priming of naive CD8+ T cells in the presence of IL-12 selectively enhances the survival of CD8+CD62Lhi cells and results in superior anti-tumor activity in a tolerogenic murine model. (Q36121187)

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English	Priming of naive CD8+ T cells in the presence of IL-12 selectively enhances the survival of CD8+CD62Lhi cells and results in superior anti-tumor activity in a tolerogenic murine model.	scientific article

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scholarly article

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4 January 2020

Priming of naive CD8+ T cells in the presence of IL-12 selectively enhances the survival of CD8+CD62Lhi cells and results in superior anti-tumor activity in a tolerogenic murine model (English)

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4 January 2020

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Mohamed L. Salem

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4 January 2020

author name string

C Marcela Díaz-Montero

1

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4 January 2020

Sabry El Naggar

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4 January 2020

Amir Al Khami

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4 January 2020

Randa El Naggar

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4 January 2020

Alberto J Montero

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4 January 2020

David J Cole

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publication date

28 August 2007

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4 January 2020

Cancer Immunology, Immunotherapy

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4 January 2020

57

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4 January 2020

563-572

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4 January 2020

4

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4 January 2020

https://scigraph.springernature.com/pub.10.1007/s00262-007-0394-0

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Review: novel nonviral delivery approaches for interleukin-12 protein and gene systems: curbing toxicity and enhancing adjuvant activity.

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Ex vivo culture with interleukin (IL)-12 improves CD8(+) T-cell adoptive immunotherapy for murine leukemia independent of IL-18 or IFN-gamma but requires perforin

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Interleukin-15 rescues tolerant CD8+ T cells for use in adoptive immunotherapy of established tumors

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Acquisition of full effector function in vitro paradoxically impairs the in vivo antitumor efficacy of adoptively transferred CD8+ T cells

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Paracrine release of IL-12 stimulates IFN-gamma production and dramatically enhances the antigen-specific T cell response after vaccination with a novel peptide-based cancer vaccine

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IL-15 enhances the in vivo antitumor activity of tumor-reactive CD8+ T cells

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CD8 T Cell Clonal Expansion and Development of Effector Function Require Prolonged Exposure to Antigen, Costimulation, and Signal 3 Cytokine

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Tumor regression and autoimmunity after reversal of a functionally tolerant state of self-reactive CD8+ T cells.

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2 October 2017

Signal 3 determines tolerance versus full activation of naive CD8 T cells: dissociating proliferation and development of effector function

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Cytokine control of memory T-cell development and survival

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2 October 2017

IL-12: a promising adjuvant for cancer vaccination

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2 October 2017

Generating potent Th1/Tc1 T cell adoptive immunotherapy doses using human IL-12: Harnessing the immunomodulatory potential of IL-12 without the in vivo-associated toxicity

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2 October 2017

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2 October 2017

The roles of IL-12 in providing a third signal for clonal expansion of naive CD8 T cells

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2 October 2017

Migratory properties of naive, effector, and memory CD8(+) T cells

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2 October 2017

Interleukin-7 mediates the homeostasis of naïve and memory CD8 T cells in vivo

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2 October 2017

The toxicology of interleukin-12: a review

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2 October 2017

gp100/pmel 17 is a murine tumor rejection antigen: induction of "self"-reactive, tumoricidal T cells using high-affinity, altered peptide ligand

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The interleukin-12/interleukin-12-receptor system: role in normal and pathologic immune responses

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2 October 2017

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IL-12 priming during in vitro antigenic stimulation changes properties of CD8 T cells and increases generation of effector and memory cells.

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Peptide antigen priming of naive, but not memory, CD8 T cells requires a third signal that can be provided by IL-12.

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Down-regulation of homing receptors after T cell activation

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12 December 2020

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IL-12 deaths: explanation and a puzzle

1 reference

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12 December 2020

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IL-12 Acts Directly on DC to Promote Nuclear Localization of NF-κB and Primes DC for IL-12 Production

1 reference

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12 December 2020

based on heuristic

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Cutting edge: Bcl-3 up-regulation by signal 3 cytokine (IL-12) prolongs survival of antigen-activated CD8 T cells

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12 December 2020

based on heuristic

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Il-12 enhances CD8 T cell homeostatic expansion

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S00262-007-0394-0

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4 January 2020

1 reference

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17726606%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

1 reference

Europe PubMed Central

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4 January 2020

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