Deficits in cognition and synaptic plasticity in a mouse model of Down syndrome ameliorated by GABAB receptor antagonists. (Q36138353)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22764230%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

title

Deficits in cognition and synaptic plasticity in a mouse model of Down syndrome ameliorated by GABAB receptor antagonists (English)

1 reference

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7 February 2020

1 reference

1 reference

Alexander M Kleschevnikov

1

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7 February 2020

Mehrdad Faizi

3

1 reference

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7 February 2020

author name string

Pavel V Belichenko

2

1 reference

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7 February 2020

Lucia F Jacobs

4

1 reference

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7 February 2020

Khin Htun

5

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7 February 2020

Mehrdad Shamloo

6

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7 February 2020

William C Mobley

7

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7 February 2020

language of work or name

English

0 references

publication date

1 July 2012

1 reference

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7 February 2020

published in

Journal of Neuroscience

1 reference

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7 February 2020

volume

32

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7 February 2020

page(s)

9217-9227

1 reference

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7 February 2020

issue

27

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describes a project that uses

7 February 2020

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3411326/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

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Trisomy of the G protein-coupled K+ channel gene, Kcnj6, affects reward mechanisms, cognitive functions, and synaptic plasticity in mice

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Developmentally altered inhibition in Ts65Dn, a mouse model of Down syndrome

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Environmental enrichment decreases GABAergic inhibition and improves cognitive abilities, synaptic plasticity, and visual functions in a mouse model of Down syndrome

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Dysfunctional hippocampal inhibition in the Ts65Dn mouse model of Down syndrome

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Chronic Treatment with a Promnesiant GABA-A α5-Selective Inverse Agonist Increases Immediate Early Genes Expression during Memory Processing in Mice and Rectifies Their Expression Levels in a Down Syndrome Mouse Model

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Specific targeting of the GABA-A receptor α5 subtype by a selective inverse agonist restores cognitive deficits in Down syndrome mice

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Olig1 and Olig2 triplication causes developmental brain defects in Down syndrome

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Cognitive deficits and associated neurological complications in individuals with Down's syndrome

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GABAB receptors modulate NMDA receptor calcium signals in dendritic spines

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Communication breaks-Down: from neurodevelopment defects to cognitive disabilities in Down syndrome

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The "Down syndrome critical region" is sufficient in the mouse model to confer behavioral, neurophysiological, and synaptic phenotypes characteristic of Down syndrome

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Dentate gyrus-specific knockdown of adult neurogenesis impairs spatial and object recognition memory in adult rats

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The functional nature of synaptic circuitry is altered in area CA3 of the hippocampus in a mouse model of Down's syndrome

2 October 2017

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Deficits in hippocampal CA1 LTP induced by TBS but not HFS in the Ts65Dn mouse: a model of Down syndrome.

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Understanding mental retardation in Down's syndrome using trisomy 16 mouse models

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2 October 2017

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Localization of a retroviral element within the rd gene coding for the beta subunit of cGMP phosphodiesterase

2 October 2017

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2 October 2017

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2 October 2017

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α-Tocopherol suppresses lipid peroxidation and behavioral and cognitive impairments in the Ts65Dn mouse model of Down syndrome.

2 October 2017

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2 July 2018

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Abnormal expression of the G-protein-activated inwardly rectifying potassium channel 2 (GIRK2) in hippocampus, frontal cortex, and substantia nigra of Ts65Dn mouse: a model of Down syndrome

2 July 2018

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Hippocampal long-term potentiation suppressed by increased inhibition in the Ts65Dn mouse, a genetic model of Down syndrome.

2 July 2018

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GABA(B) receptor antagonist CGP-36742 enhances somatostatin release in the rat hippocampus in vivo and in vitro

2 July 2018

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Immunohistochemical localization of GABA(B) receptors in the rat central nervous system

2 July 2018

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Altered long-term potentiation in the young and old Ts65Dn mouse, a model for Down Syndrome.

2 July 2018

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Effect of neuropeptides on cognitive function.

2 July 2018

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Long-term memory in mental retardation: evidence for a specific impairment in subjects with Down's syndrome.

2 July 2018

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Facilitation of the induction of long-term potentiation by GABAB receptors.

2 July 2018

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Increased acetylcholine and quisqualate responsiveness after blockade of GABAB receptors

2 July 2018

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Genetic analysis of Down syndrome facilitated by mouse chromosome engineering.

2 July 2018

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When is the hippocampus involved in recognition memory?

23 September 2018

1 reference

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Three-dimensional synaptic ultrastructure in the dentate gyrus and hippocampal area CA3 in the Ts65Dn mouse model of Down syndrome

23 September 2018

1 reference

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Prevention of learning deficit in a Down syndrome model.

23 September 2018

1 reference

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Restoration of norepinephrine-modulated contextual memory in a mouse model of Down syndrome.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3411326

Alteration of inhibitory circuits in the somatosensory cortex of Ts65Dn mice, a model for Down's syndrome.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3411326

Excitatory-inhibitory relationship in the fascia dentata in the Ts65Dn mouse model of Down syndrome

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3411326

Chronic pentylenetetrazole but not donepezil treatment rescues spatial cognition in Ts65Dn mice, a model for Down syndrome

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3411326

Acute injections of the NMDA receptor antagonist memantine rescue performance deficits of the Ts65Dn mouse model of Down syndrome on a fear conditioning test.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3411326

Synaptic and cognitive abnormalities in mouse models of Down syndrome: exploring genotype-phenotype relationships

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3411326

Object recognition memory is conserved in Ts1Cje, a mouse model of Down syndrome.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3411326

Object recognition in rats and mice: a one-trial non-matching-to-sample learning task to study 'recognition memory'.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3411326

Pharmacotherapy for cognitive impairment in a mouse model of Down syndrome.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3411326

Ts65Dn, a mouse model of Down syndrome, exhibits increased GABAB-induced potassium current.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3411326

Down syndrome mouse models are looking up.

23 September 2018

1 reference

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Compartment-dependent colocalization of Kir3.2-containing K+ channels and GABAB receptors in hippocampal pyramidal cells.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3411326

GABAB receptor antagonist SGS742 improves spatial memory and reduces protein binding to the cAMP response element (CRE) in the hippocampus

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3411326

Synaptic structural abnormalities in the Ts65Dn mouse model of Down Syndrome.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3411326

Subcellular localization of metabotropic GABA(B) receptor subunits GABA(B1a/b) and GABA(B2) in the rat hippocampus.

23 September 2018

1 reference

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GABA(B) receptor inhibition causes locomotor stimulation in mice

23 September 2018

1 reference

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Implicit versus explicit memory function in children with Down and Williams syndrome.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3411326

Comparative immunohistochemical localisation of GABA(B1a), GABA(B1b) and GABA(B2) subunits in rat brain, spinal cord and dorsal root ganglion

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3411326

Effects of high-affinity GABAB receptor antagonists on active and passive avoidance responding in rodents with gamma-hydroxybutyrolactone-induced absence syndrome

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3411326

Ts65Dn mice, a model for Down syndrome, have deficits in context discrimination learning suggesting impaired hippocampal function.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3411326

Genetic dissection of region associated with behavioral abnormalities in mouse models for Down syndrome

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3411326

Comparison of antagonist potencies at pre- and post-synaptic GABA(B) receptors at inhibitory synapses in the CA1 region of the rat hippocampus

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3411326

GABAB receptor antagonism: facilitatory effects on memory parallel those on LTP induced by TBS but not HFS.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3411326

The modulatory effects of high affinity GABA(B) receptor antagonists in an active avoidance learning paradigm in rats.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3411326

G protein-coupled inwardly rectifying K+ channels (GIRKs) mediate postsynaptic but not presynaptic transmitter actions in hippocampal neurons

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3411326

An immunocytochemical study on the distribution of two G-protein-gated inward rectifier potassium channels (GIRK2 and GIRK4) in the adult rat brain.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3411326

The actions of orally active GABAB receptor antagonists on GABAergic transmission in vivo and in vitro

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3411326

CGP 36742: the first orally active GABAB blocker improves the cognitive performance of mice, rats, and rhesus monkeys.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3411326

The hippocampus in Down's syndrome.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3411326

GABAB receptor antagonists elevate both mRNA and protein levels of the neurotrophins nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) but not neurotrophin-3 (NT-3) in brain and spinal cord of rats

23 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22764230

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Over-inhibition: a model for developmental intellectual disability

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22764230

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1523/JNEUROSCI.1673-12.2012

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22764230%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22764230%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

1 reference