Synaptic and cognitive abnormalities in mouse models of Down syndrome: exploring genotype-phenotype relationships (Q46464782)

22 December 2017

title

Synaptic and cognitive abnormalities in mouse models of Down syndrome: exploring genotype-phenotype relationships (English)

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22 December 2017

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22 December 2017

author name string

Pavel V Belichenko

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22 December 2017

Alexander M Kleschevnikov

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22 December 2017

Charles J Epstein

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22 December 2017

William C Mobley

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22 December 2017

language of work or name

English

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publication date

1 October 2007

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22 December 2017

The Journal of Comparative Neurology

published in

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22 December 2017

volume

504

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22 December 2017

page(s)

329-345

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22 December 2017

issue

4

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22 December 2017

Dscam is associated with axonal and dendritic features of neuronal cells.

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DYRK1A BAC transgenic mice show altered synaptic plasticity with learning and memory defects.

21 January 2018

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Neurodevelopmental delay, motor abnormalities and cognitive deficits in transgenic mice overexpressing Dyrk1A (minibrain), a murine model of Down's syndrome.

21 January 2018

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Dosage-dependent over-expression of genes in the trisomic region of Ts1Cje mouse model for Down syndrome.

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Excessive expression of synaptojanin in brains with Down syndrome.

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Evidence against the overexpression of APP in Down syndrome.

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Differences in beta-amyloid (beta/A4) deposition in human patients with Down's syndrome and sporadic Alzheimer's disease.

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NFAT dysregulation by increased dosage of DSCR1 and DYRK1A on chromosome 21.

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Constitutive overexpression of Cu/Zn superoxide dismutase exacerbates kainic acid-induced apoptosis of transgenic-Cu/Zn superoxide dismutase neurons

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Synaptic structural abnormalities in the Ts65Dn mouse model of Down Syndrome.

21 January 2018

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Uptake of glutamate into synaptic vesicles by an inorganic phosphate transporter

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Regulation and expression of the Alzheimer's beta/A4 amyloid protein precursor in health, disease, and Down's syndrome

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Transgenic mouse in vivo library of human Down syndrome critical region 1: association between DYRK1A overexpression, brain development abnormalities, and cell cycle protein alteration

21 January 2018

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Spatial representation and attention in toddlers with Williams syndrome and Down syndrome

21 January 2018

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Depolarization of neural cells induces transcription of the Down syndrome critical region 1 isoform 4 via a calcineurin/nuclear factor of activated T cells-dependent pathway

21 January 2018

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Abnormalities of the nucleus basalis in Down's syndrome

21 January 2018

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The mouse brain transcriptome by SAGE: differences in gene expression between P30 brains of the partial trisomy 16 mouse model of Down syndrome (Ts65Dn) and normals

21 January 2018

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Failed retrograde transport of NGF in a mouse model of Down's syndrome: reversal of cholinergic neurodegenerative phenotypes following NGF infusion

21 January 2018

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Deficits in hippocampal CA1 LTP induced by TBS but not HFS in the Ts65Dn mouse: a model of Down syndrome.

21 January 2018

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Spatial memory deficits in segmental trisomic Ts65Dn mice.

21 January 2018

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Impaired spatial working and reference memory in segmental trisomy (Ts65Dn) mice.

21 January 2018

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Alterations of central noradrenergic transmission in Ts65Dn mouse, a model for Down syndrome

21 January 2018

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Alterations of neocortical pyramidal cell phenotype in the Ts65Dn mouse model of Down syndrome: effects of environmental enrichment

21 January 2018

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Mild impairment of learning and memory in mice overexpressing the mSim2 gene located on chromosome 16: an animal model of Down's syndrome

21 January 2018

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Transgenic mice with increased Cu/Zn-superoxide dismutase activity: animal model of dosage effects in Down syndrome

21 January 2018

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A behavioral assessment of Ts65Dn mice: a putative Down syndrome model.

21 January 2018

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Impaired short- and long-term memory in Ts65Dn mice, a model for Down syndrome.

21 January 2018

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Reversible impairment of long-term potentiation in transgenic Cu/Zn-SOD mice.

21 January 2018

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Mouse models of Down syndrome: how useful can they be? Comparison of the gene content of human chromosome 21 with orthologous mouse genomic regions

21 January 2018

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Behavioral tests of hippocampal function: simple paradigms complex problems

21 January 2018

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Loss of cholinergic phenotype in basal forebrain coincides with cognitive decline in a mouse model of Down's syndrome

21 January 2018

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Estrogen restores cognition and cholinergic phenotype in an animal model of Down syndrome

21 January 2018

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Elevated expression of the G-protein-activated inwardly rectifying potassium channel 2 (GIRK2) in cerebellar unipolar brush cells of a Down syndrome mouse model.

21 January 2018

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Abnormal expression of the G-protein-activated inwardly rectifying potassium channel 2 (GIRK2) in hippocampus, frontal cortex, and substantia nigra of Ts65Dn mouse: a model of Down syndrome

21 January 2018

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Functional and morphological alterations in compound transgenic mice overexpressing Cu/Zn superoxide dismutase and amyloid precursor protein [correction].

21 January 2018

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The DNA sequence of human chromosome 21

21 January 2018

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Developmental abnormalities and age-related neurodegeneration in a mouse model of Down syndrome

21 January 2018

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Aging-dependent alterations in synaptic plasticity and memory in mice that overexpress extracellular superoxide dismutase.

21 January 2018

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21 January 2018

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Hippocampal long-term potentiation suppressed by increased inhibition in the Ts65Dn mouse, a genetic model of Down syndrome.

21 January 2018

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Down syndrome phenotypes: the consequences of chromosomal imbalance

21 January 2018

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The neurobiological basis of spontaneous alternation

21 January 2018

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Localization of 102 exons to a 2.5 Mb region involved in Down syndrome.

21 January 2018

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Primary and secondary transcriptional effects in the developing human Down syndrome brain and heart

21 January 2018

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The Runx1/AML1 transcription factor selectively regulates development and survival of TrkA nociceptive sensory neurons.

21 January 2018

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Molecular genetic approach to the characterization of the "Down syndrome region" of chromosome 21.

21 January 2018

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Regulation of Tiam1-Rac signalling.

21 January 2018

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Human chromosome 21/Down syndrome gene function and pathway database

21 January 2018

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An aneuploid mouse strain carrying human chromosome 21 with Down syndrome phenotypes

21 January 2018

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Down syndrome mouse models Ts65Dn, Ts1Cje, and Ms1Cje/Ts65Dn exhibit variable severity of cerebellar phenotypes.

21 January 2018

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The neuropsychology of Down syndrome: evidence for hippocampal dysfunction

21 January 2018

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Transcriptional disruptions in Down syndrome: a case study in the Ts1Cje mouse cerebellum during post-natal development.

21 January 2018

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Alu-splice cloning of human Intersectin (ITSN), a putative multivalent binding protein expressed in proliferating and differentiating neurons and overexpressed in Down syndrome

21 January 2018

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Polymerase chain reaction method to identify Down syndrome model segmentally trisomic mice

21 January 2018

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Too much of a good thing: mechanisms of gene action in Down syndrome.

21 January 2018

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A mouse model for Down syndrome exhibits learning and behaviour deficits.

21 January 2018

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21 January 2018

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Ts1Cje, a partial trisomy 16 mouse model for Down syndrome, exhibits learning and behavioral abnormalities

21 January 2018

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Genetic dissection of region associated with behavioral abnormalities in mouse models for Down syndrome

21 January 2018

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Increased App expression in a mouse model of Down's syndrome disrupts NGF transport and causes cholinergic neuron degeneration.

21 January 2018

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Global disruption of the cerebellar transcriptome in a Down syndrome mouse model.

21 January 2018

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Abnormal APP, cholinergic and cognitive function in Ts65Dn Down's model mice

21 January 2018

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Altered long-term potentiation in the young and old Ts65Dn mouse, a model for Down Syndrome.

21 January 2018

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Increased synaptic depression in the Ts65Dn mouse, a model for mental retardation in Down syndrome.

21 January 2018

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Regulating the actin cytoskeleton during vesicular transport.

21 January 2018

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Comparative genomic sequence analysis of the human chromosome 21 Down syndrome critical region

21 January 2018

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Hemisphere and gender differences in mental rotation.

21 January 2018

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Overexpression of mSim2 gene in the zona limitans of the diencephalon of segmental trisomy 16 Ts1Cje fetuses, a mouse model for trisomy 21: a novel whole-mount based RNA hybridization study.

21 January 2018

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Identification and characterization of a new Down syndrome model, Ts[Rb(12.1716)]2Cje, resulting from a spontaneous Robertsonian fusion between T(171)65Dn and mouse chromosome 12.

21 January 2018

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Catecholamines and cholinergic enzymes in pre-senile and senile Alzheimer-type dementia and down's syndrome

21 January 2018

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The polarity protein PAR-3 and TIAM1 cooperate in dendritic spine morphogenesis

21 January 2018

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Gene expression variation and expression quantitative trait mapping of human chromosome 21 genes

21 January 2018

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Mice trisomic for a bacterial artificial chromosome with the single-minded 2 gene (Sim2) show phenotypes similar to some of those present in the partial trisomy 16 mouse models of Down syndrome

21 January 2018

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Dendritic Spine Pathology: Cause or Consequence of Neurological Disorders?

21 January 2018

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Molecular mapping of twenty-four features of Down syndrome on chromosome 21.

21 January 2018

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7 January 2021

Upregulation of GABA neurotransmission suppresses hippocampal excitability and prevents long-term potentiation in transgenic superoxide dismutase-overexpressing mice

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7 January 2021

Synaptojanin 1 contributes to maintaining the stability of GABAergic transmission in primary cultures of cortical neurons.

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7 January 2021

The pathogenesis of aneuploid phenotypes: the fallacy of explanatory reductionism

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7 January 2021

The dendritic spine: a multifunctional integrative unit

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7 January 2021

Abnormal synaptic plasticity in the Ts1Cje segmental trisomy 16 mouse model of Down syndrome

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7 January 2021

Identifiers

DOI

10.1002/CNE.21433

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22 December 2017

PubMed ID

17663443

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22 December 2017