The RB protein family in retinal development and retinoblastoma: new insights from new mouse models (Q36108537)

12 August 2017

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title

The RB protein family in retinal development and retinoblastoma: new insights from new mouse models (English)

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12 August 2017

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Danian Chen

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Rod Bremner

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Rod Bremner

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1

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Marek Pacal

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3

object named as

Marek Pacal

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12 August 2017

5

Mahima Agochiya

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12 August 2017

Izhar Livne-Bar

4

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PubMed ID

15855771

12 August 2017

language of work or name

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1 September 2004

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Developmental Neuroscience

12 August 2017

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12 August 2017

26

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12 August 2017

5-6

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12 August 2017

417-434

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A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma

12 August 2017

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Retinoblastoma: the disease, gene and protein provide critical leads to understand cancer.

21 January 2018

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The retinoblastoma tumour suppressor in development and cancer

21 January 2018

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17AAG: low target binding affinity and potent cell activity--finding an explanation

21 January 2018

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Emerging roles for E2F: Beyond the G1/S transition and DNA replication

21 January 2018

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Coordinated regulation of life and death by RB.

21 January 2018

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The retinoblastoma gene family: cousins with overlapping interests.

21 January 2018

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The retinoblastoma family: twins or distant cousins?

21 January 2018

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Requirement for a functional Rb-1 gene in murine development

21 January 2018

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Effects of an Rb mutation in the mouse

21 January 2018

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Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis

21 January 2018

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Strain-dependent myeloid hyperplasia, growth deficiency, and accelerated cell cycle in mice lacking the Rb-related p107 gene.

21 January 2018

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E2F3 contributes both to the inappropriate proliferation and to the apoptosis arising in Rb mutant embryos

21 January 2018

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E2F4 loss suppresses tumorigenesis in Rb mutant mice.

21 January 2018

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Expression of transcription factor E2F1 induces quiescent cells to enter S phase

21 January 2018

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Deregulated expression of E2F family members induces S-phase entry and overcomes p16INK4A-mediated growth suppression

21 January 2018

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Cellular targets for activation by the E2F1 transcription factor include DNA synthesis- and G1/S-regulatory genes

21 January 2018

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CDC25A phosphatase is a target of E2F and is required for efficient E2F-induced S phase

21 January 2018

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E2Fs regulate the expression of genes involved in differentiation, development, proliferation, and apoptosis.

21 January 2018

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Expression analysis using DNA microarrays demonstrates that E2F-1 up-regulates expression of DNA replication genes including replication protein A2.

21 January 2018

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Role for E2F in control of both DNA replication and mitotic functions as revealed from DNA microarray analysis

21 January 2018

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Identification of novel E2F1-regulated genes by microarray

21 January 2018

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Gene expression changes in response to E2F1 activation.

21 January 2018

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The E2F1-3 transcription factors are essential for cellular proliferation.

21 January 2018

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Target gene specificity of E2F and pocket protein family members in living cells

21 January 2018

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E2F mediates cell cycle-dependent transcriptional repression in vivo by recruitment of an HDAC1/mSin3B corepressor complex

21 January 2018

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Isolating human transcription factor targets by coupling chromatin immunoprecipitation and CpG island microarray analysis

21 January 2018

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E2F integrates cell cycle progression with DNA repair, replication, and G(2)/M checkpoints

21 January 2018

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21 January 2018

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The retinoblastoma protein and cell cycle control

21 January 2018

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Acute mutation of retinoblastoma gene function is sufficient for cell cycle re-entry

21 January 2018

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Tumour-derived p16 alleles encoding proteins defective in cell-cycle inhibition

21 January 2018

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E2F4 and E2F5 play an essential role in pocket protein-mediated G1 control

21 January 2018

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Life and death decisions by E2F-1.

21 January 2018

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Direct coupling of the cell cycle and cell death machinery by E2F.

21 January 2018

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Differential regulation of E2F1 apoptotic target genes in response to DNA damage.

21 January 2018

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Telencephalon-specific Rb knockouts reveal enhanced neurogenesis, survival and abnormal cortical development

21 January 2018

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Conditional mutation of Rb causes cell cycle defects without apoptosis in the central nervous system

21 January 2018

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Extra-embryonic function of Rb is essential for embryonic development and viability

21 January 2018

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Rb and p107 are required for normal cerebellar development and granule cell survival but not for Purkinje cell persistence.

21 January 2018

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Cell-specific effects of RB or RB/p107 loss on retinal development implicate an intrinsically death-resistant cell-of-origin in retinoblastoma

21 January 2018

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21 January 2018

The Hallmarks of Cancer

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pRB plays an essential role in cell cycle arrest induced by DNA damage

21 January 2018

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RB-dependent S-phase response to DNA damage

21 January 2018

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RB signaling prevents replication-dependent DNA double-strand breaks following genotoxic insult

21 January 2018

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Retinoblastoma protein enhances the fidelity of chromosome segregation mediated by hsHec1p

21 January 2018

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E2Fs up-regulate expression of genes involved in DNA replication, DNA repair and mitosis

21 January 2018

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Centrosome duplication in mammalian somatic cells requires E2F and Cdk2-cyclin A.

21 January 2018

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Inactivation of E2F3 results in centrosome amplification

21 January 2018

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Nuclear organization of DNA replication in primary mammalian cells.

21 January 2018

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DNA replication control through interaction of E2F-RB and the origin recognition complex

21 January 2018

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Rb inactivation promotes genomic instability by uncoupling cell cycle progression from mitotic control.

21 January 2018

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Sensitive and efficient detection of RB1 gene mutations enhances care for families with retinoblastoma

21 January 2018

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Cell fate determination in the vertebrate retina

21 January 2018

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Retinal stem cells in the adult mammalian eye

21 January 2018

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The retinoblastoma gene family is differentially expressed during embryogenesis.

21 January 2018

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Rb regulates proliferation and rod photoreceptor development in the mouse retina

21 January 2018

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Retinoblastoma. Cell of origin.

21 January 2018

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Comparative genomic hybridization of 49 primary retinoblastoma tumors identifies chromosomal regions associated with histopathology, progression, and patient outcome.

21 January 2018

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Human papillomavirus type 16 E7 oncoprotein can induce abnormal centrosome duplication through a mechanism independent of inactivation of retinoblastoma protein family members

21 January 2018

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Retinoblastoma-like neoplasm induced in C3H/BifB/Ki strain mice by human adenovirus serotype 12.

21 January 2018

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Retinoblastoma in transgenic mice

21 January 2018

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Retinoblastoma in transgenic mice: models of hereditary retinoblastoma

21 January 2018

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Bilateral retinal and brain tumors in transgenic mice expressing simian virus 40 large T antigen under control of the human interphotoreceptor retinoid-binding protein promoter

21 January 2018

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Cell-autonomous and non-cell-autonomous functions of the Rb tumor suppressor in developing central nervous system

21 January 2018

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p53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens.

21 January 2018

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Unique and overlapping functions of pRb and p107 in the control of proliferation and differentiation in epidermis

21 January 2018

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The retinoblastoma gene family in differentiation and development.

21 January 2018

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Tumor formation in mice with somatic inactivation of the retinoblastoma gene in interphotoreceptor retinol binding protein-expressing cells

21 January 2018

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A critical temporal requirement for the retinoblastoma protein family during neuronal determination

21 January 2018

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Regulating proliferation during retinal development

21 January 2018

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Mice lacking p27(Kip1) display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors

21 January 2018

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Genetic evidence for the interactions of cyclin D1 and p27(Kip1) in mice

21 January 2018

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Deletion of the p27Kip1 gene restores normal development in cyclin D1-deficient mice

21 January 2018

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p27(Kip1) regulates cell cycle withdrawal of late multipotent progenitor cells in the mammalian retina.

21 January 2018

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The cyclin-dependent kinase inhibitors p19(Ink4d) and p27(Kip1) are coexpressed in select retinal cells and act cooperatively to control cell cycle exit

21 January 2018

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Persistent expression of cyclin D1 disrupts normal photoreceptor differentiation and retina development.

21 January 2018

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The proliferative and apoptotic activities of E2F1 in the mouse retina

21 January 2018

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Recapitulation of the effects of the human papillomavirus type 16 E7 oncogene on mouse epithelium by somatic Rb deletion and detection of pRb-independent effects of E7 in vivo

21 January 2018

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Minimal regions of chromosomal imbalance in retinoblastoma detected by comparative genomic hybridization

21 January 2018

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Retinoblastoma-protein-dependent cell-cycle inhibition by the tumour suppressor p16

21 January 2018

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Shared role of the pRB-related p130 and p107 proteins in limb development

21 January 2018

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5 June 2022

https://opencitations.net/index/coci/api/v1/citations/10.1101/GAD.10.13.1633

Identifiers

DOI

10.1159/000082284

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release_4t54b27zl5a5npb7naoi5rhldy

12 August 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/4t54b27zl5a5npb7naoi5rhldy

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24 November 2022

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PubMed ID

15855771

1 reference

PubMed ID

15855771