Targeting chromatin binding regulation of constitutively active AR variants to overcome prostate cancer resistance to endocrine-based therapies (Q35842471)

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scientific article published on 23 April 2015

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English	Targeting chromatin binding regulation of constitutively active AR variants to overcome prostate cancer resistance to endocrine-based therapies	scientific article published on 23 April 2015

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scholarly article

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6 March 2020

Targeting chromatin binding regulation of constitutively active AR variants to overcome prostate cancer resistance to endocrine-based therapies (English)

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6 March 2020

prostate cancer

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based on heuristic

inferred from title

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6 March 2020

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6 March 2020

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Siu Chiu Chan

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6 March 2020

Yingming Li

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6 March 2020

Michael D Nyquist

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6 March 2020

Lu Miao

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6 March 2020

James E Bradner

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6 March 2020

Ganesh V Raj

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6 March 2020

Scott M Dehm

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23 April 2015

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6 March 2020

Nucleic Acids Research

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6 March 2020

43

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6 March 2020

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6 March 2020

5880-5897

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6 March 2020

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Creative Commons Attribution 4.0 International

8 May 2017

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0 references

AR-V7 and resistance to enzalutamide and abiraterone in prostate cancer

1 reference

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11 July 2018

The cistrome and gene signature of androgen receptor splice variants in castration resistant prostate cancer cells

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11 July 2018

Androgen receptor and its splice variant, AR-V7, differentially regulate FOXA1 sensitive genes in LNCaP prostate cancer cells

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11 July 2018

Enzalutamide in metastatic prostate cancer before chemotherapy

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11 July 2018

Biologic and clinical significance of androgen receptor variants in castration resistant prostate cancer

1 reference

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11 July 2018

Therapeutic targeting of BET bromodomain proteins in castration-resistant prostate cancer

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11 July 2018

Androgen receptor splice variants activating the full-length receptor in mediating resistance to androgen-directed therapy

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11 July 2018

Androgen receptor uses relaxed response element stringency for selective chromatin binding and transcriptional regulation in vivo.

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11 July 2018

Rapid induction of androgen receptor splice variants by androgen deprivation in prostate cancer.

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A novel androgen-regulated isoform of the TSC2 tumour suppressor gene increases cell proliferation.

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11 July 2018

Molecular pathways: targeting resistance in the androgen receptor for therapeutic benefit

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11 July 2018

Inhibition of BET bromodomain proteins as a therapeutic approach in prostate cancer

1 reference

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11 July 2018

TALEN-engineered AR gene rearrangements reveal endocrine uncoupling of androgen receptor in prostate cancer.

1 reference

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11 July 2018

lncRNA-dependent mechanisms of androgen-receptor-regulated gene activation programs.

1 reference

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11 July 2018

Mechanisms of the androgen receptor splicing in prostate cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4499120

11 July 2018

Molecular classification of prostate cancer progression: foundation for marker-driven treatment of prostate cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4499120

11 July 2018

diffReps: detecting differential chromatin modification sites from ChIP-seq data with biological replicates

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4499120

11 July 2018

Selective inhibition of tumor oncogenes by disruption of super-enhancers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4499120

11 July 2018

Abiraterone in metastatic prostate cancer without previous chemotherapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4499120

11 July 2018

Androgen receptor splice variants mediate enzalutamide resistance in castration-resistant prostate cancer cell lines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4499120

11 July 2018

Distinct transcriptional programs mediated by the ligand-dependent full-length androgen receptor and its splice variants in castration-resistant prostate cancer.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4499120

11 July 2018

Evidence for DNA-binding domain--ligand-binding domain communications in the androgen receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4499120

11 July 2018

Androgen receptor splice variants activate androgen receptor target genes and support aberrant prostate cancer cell growth independent of canonical androgen receptor nuclear localization signal

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4499120

11 July 2018

AR intragenic deletions linked to androgen receptor splice variant expression and activity in models of prostate cancer progression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4499120

11 July 2018

Androgen receptor variants occur frequently in castration resistant prostate cancer metastases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4499120

11 July 2018

BET bromodomain inhibition as a therapeutic strategy to target c-Myc

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4499120

11 July 2018

Androgen receptor rediscovered: the new biology and targeting the androgen receptor therapeutically

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11 July 2018

Cistrome: an integrative platform for transcriptional regulation studies

1 reference

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11 July 2018

The androgen receptor fuels prostate cancer by regulating central metabolism and biosynthesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4499120

11 July 2018

Reprogramming transcription by distinct classes of enhancers functionally defined by eRNA

1 reference

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11 July 2018

Expression of androgen receptor splice variants in prostate cancer bone metastases is associated with castration-resistance and short survival

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4499120

11 July 2018

Intragenic rearrangement and altered RNA splicing of the androgen receptor in a cell-based model of prostate cancer progression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4499120

11 July 2018

Integrative genomics viewer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4499120

11 July 2018

Selective inhibition of BET bromodomains

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4499120

11 July 2018

Constitutively active androgen receptor splice variants expressed in castration-resistant prostate cancer require full-length androgen receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4499120

11 July 2018

Castration resistance in human prostate cancer is conferred by a frequently occurring androgen receptor splice variant

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4499120

11 July 2018

Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities

1 reference

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11 July 2018

Starving the addiction: new opportunities for durable suppression of AR signaling in prostate cancer

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Fast and accurate short read alignment with Burrows-Wheeler transform

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11 July 2018

A novel androgen receptor splice variant is up-regulated during prostate cancer progression and promotes androgen depletion-resistant growth

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4499120

11 July 2018

Ligand-independent androgen receptor variants derived from splicing of cryptic exons signify hormone-refractory prostate cancer

1 reference

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An integrated software system for analyzing ChIP-chip and ChIP-seq data

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11 July 2018

Model-based analysis of ChIP-Seq (MACS)

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11 July 2018

Splicing of a novel androgen receptor exon generates a constitutively active androgen receptor that mediates prostate cancer therapy resistance

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11 July 2018

Recurrent gene fusions in prostate cancer

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11 July 2018

Prostate epithelial cell fate.

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11 July 2018

JASPAR, the open access database of transcription factor-binding profiles: new content and tools in the 2008 update

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11 July 2018

Regulation of Cidea protein stability by the ubiquitin-mediated proteasomal degradation pathway

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11 July 2018

Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles

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Galaxy: a platform for interactive large-scale genome analysis

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11 July 2018

Structural basis of androgen receptor binding to selective androgen response elements.

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Transcript levels of androgen receptor variant AR-V1 or AR-V7 do not predict recurrence in patients with prostate cancer at indeterminate risk for progression

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12 December 2020

based on heuristic

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Stepwise androgen receptor dimerization

1 reference

https://pubmed.ncbi.nlm.nih.gov/25908785

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1093/NAR/GKV262

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25908785%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

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6 March 2020

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6 March 2020

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