Loop II of DNA polymerase beta is important for polymerization activity and fidelity (Q35837379)

10 August 2017

Loop II of DNA polymerase beta is important for polymerization activity and fidelity (English)

1 reference

10 August 2017

3

Joann B Sweasy

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10 August 2017

George C Lin

1

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10 August 2017

Joachim Jaeger

series ordinal

2

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10 August 2017

language of work or name

English

0 references

publication date

16 April 2007

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10 August 2017

Nucleic Acids Research

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10 August 2017

35

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10 August 2017

9

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10 August 2017

2924-2935

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describes a project that uses

10 August 2017

ImageQuant

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC1888816/fullTextXML

inferred from PubMed Central ID database lookup

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A closed conformation for the Pol lambda catalytic cycle.

11 July 2018

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Repair and genetic consequences of endogenous DNA base damage in mammalian cells

11 July 2018

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A structural solution for the DNA polymerase lambda-dependent repair of DNA gaps with minimal homology

11 July 2018

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Variants of DNA polymerase Beta extend mispaired DNA due to increased affinity for nucleotide substrate

11 July 2018

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Structure of DNA polymerase beta with the mutagenic DNA lesion 8-oxodeoxyguanine reveals structural insights into its coding potential

11 July 2018

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Crystal structures of a template-independent DNA polymerase: murine terminal deoxynucleotidyltransferase

11 July 2018

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A DNA polymerase beta mutator mutant with reduced nucleotide discrimination and increased protein stability

11 July 2018

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Insight into the catalytic mechanism of DNA polymerase beta: structures of intermediate complexes

11 July 2018

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DNA synthesis and dRPase activities of polymerase beta are both essential for single-nucleotide patch base excision repair in mammalian cell extracts.

11 July 2018

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DNA structure and aspartate 276 influence nucleotide binding to human DNA polymerase beta. Implication for the identity of the rate-limiting conformational change

11 July 2018

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DNA polymerase lambda (Pol lambda), a novel eukaryotic DNA polymerase with a potential role in meiosis

11 July 2018

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DNA ligases in the repair and replication of DNA.

11 July 2018

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Structural design of a eukaryotic DNA repair polymerase: DNA polymerase beta.

11 July 2018

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Initiation of base excision repair: glycosylase mechanisms and structures

11 July 2018

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The E249K mutator mutant of DNA polymerase beta extends mispaired termini

11 July 2018

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The Tyr-265-to-Cys mutator mutant of DNA polymerase beta induces a mutator phenotype in mouse LN12 cells

11 July 2018

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3'-Azido-3'-deoxythymidine-resistant mutants of DNA polymerase beta identified by in vivo selection

11 July 2018

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Impairment of proliferating cell nuclear antigen-dependent apurinic/apyrimidinic site repair on linear DNA.

11 July 2018

1 reference

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Crystal structures of human DNA polymerase beta complexed with gapped and nicked DNA: evidence for an induced fit mechanism

11 July 2018

1 reference

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Development and use of an in vitro HSV-tk forward mutation assay to study eukaryotic DNA polymerase processing of DNA alkyl lesions

11 July 2018

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A genetic system to identify DNA polymerase beta mutator mutants

11 July 2018

1 reference

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Reconstitution of DNA base excision-repair with purified human proteins: interaction between DNA polymerase beta and the XRCC1 protein

11 July 2018

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Crystal structures of human DNA polymerase beta complexed with DNA: implications for catalytic mechanism, processivity, and fidelity

11 July 2018

1 reference

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DNA polymerase beta: pre-steady-state kinetic analysis and roles of arginine-283 in catalysis and fidelity.

11 July 2018

1 reference

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Requirement of mammalian DNA polymerase-beta in base-excision repair.

11 July 2018

1 reference

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Instability and decay of the primary structure of DNA

11 July 2018

1 reference

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2.3 A crystal structure of the catalytic domain of DNA polymerase beta

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1888816

Repair of oxidative damage to DNA: enzymology and biology

11 July 2018

1 reference

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Conformational coupling in DNA polymerase fidelity

11 July 2018

1 reference

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Excision of deoxyribose phosphate residues by DNA polymerase beta during DNA repair

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1888816

Structures of ternary complexes of rat DNA polymerase beta, a DNA template-primer, and ddCTP

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1888816

Fidelity of DNA synthesis

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1888816

The mutational specificity of DNA polymerase-beta during in vitro DNA synthesis. Production of frameshift, base substitution, and deletion mutations.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1888816

Recovery from ultraviolet light-induced inhibition of DNA synthesis requires umuDC gene products in recA718 mutant strains but not in recA+ strains of Escherichia coli

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1888816

An 8-fold beta alpha barrel protein with redundant folding possibilities

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1888816

The importance of surface loops for stabilizing an eightfold βα barrel protein

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1888816

The hydrophobic hinge region of rat DNA polymerase beta is critical for substrate binding pocket geometry

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1888816

Use of viscogens, dNTPalphaS, and rhodium(III) as probes in stopped-flow experiments to obtain new evidence for the mechanism of catalysis by DNA polymerase beta.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1888816

Hinge residue Ile260 of DNA polymerase beta is important for enzyme activity and fidelity

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1888816

Misalignment-mediated DNA polymerase beta mutations: comparison of microsatellite and frame-shift error rates using a forward mutation assay

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1888816

Loss of DNA polymerase beta stacking interactions with templating purines, but not pyrimidines, alters catalytic efficiency and fidelity.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1888816

Low fidelity mutants in the O-helix of Thermus aquaticus DNA polymerase I.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1888816

Mammalian DNA polymerase beta can substitute for DNA polymerase I during DNA replication in Escherichia coli

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1888816

DNA polymerase beta: multiple conformational changes in the mechanism of catalysis

24 September 2018

1 reference

12 December 2020

The mutator form of polymerase beta with amino acid substitution at tyrosine 265 in the hinge region displays an increase in both base substitution and frame shift errors

1 reference

12 December 2020

Involvement of phenylalanine 272 of DNA polymerase beta in discriminating between correct and incorrect deoxynucleoside triphosphates

1 reference

12 December 2020

Base substitution specificity of DNA polymerase beta depends on interactions in the DNA minor groove

1 reference

12 December 2020

Prostate-cancer-associated I260M variant of DNA polymerase beta is a sequence-specific mutator

1 reference

12 December 2020

Y265H mutator mutant of DNA polymerase beta. Proper teometric alignment is critical for fidelity

1 reference

12 December 2020

The D246V mutant of DNA polymerase beta misincorporates nucleotides: evidence for a role for the flexible loop in DNA positioning within the active site

1 reference

12 December 2020

Identifiers

DOI

10.1093/NAR/GKM126

1 reference

10 August 2017

1 reference

10 August 2017

1 reference