Inhibition of the Mitochondrial Protease ClpP as a Therapeutic Strategy for Human Acute Myeloid Leukemia. (Q35708954)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26058080%20AND%20SRC:MED&resulttype=core&format=json

16 February 2020

title

Inhibition of the Mitochondrial Protease ClpP as a Therapeutic Strategy for Human Acute Myeloid Leukemia (English)

1 reference

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16 February 2020

1 reference

27

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Etienne Coyaud

3

1 reference

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16 February 2020

Ashwin Ramakrishnan

17

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16 February 2020

John Dick

30

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Jason Moffat

32

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Gary D. Bader

35

1 reference

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Aaron Schimmer

39

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34

Connie J Eaves

1 reference

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16 February 2020

13

Danny V Jeyaraju

1 reference

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4

Veronique Voisin

1 reference

16 February 2020

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8

Rose Hurren

1 reference

16 February 2020

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37

Steven M Kornblau

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16 February 2020

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28

Erno Wienholds

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16 February 2020

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6

Yulia Jitkova

1 reference

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Alicia Cole

1

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Zezhou Wang

2

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16 February 2020

Marcela Gronda

5

1 reference

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Rachel Mattson

7

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Sonja Babovic

9

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Neil Maclean

10

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Ian Restall

11

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Xiaoming Wang

12

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Mahadeo A Sukhai

14

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Swayam Prabha

15

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Shaheena Bashir

16

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Elisa Leung

18

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Yi Hua Qia

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Nianxian Zhang

20

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Troy Ketela

22

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Fengshu Lin

23

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Walid A Houry

24

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Ahmed Aman

25

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Rima Al-Awar

26

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Chang Jiang Xu

29

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Jean C Y Wang

31

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Mark D Minden

33

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36

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38

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publication date

1 June 2015

1 reference

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16 February 2020

1 reference

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16 February 2020

volume

27

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16 February 2020

issue

6

1 reference

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16 February 2020

page(s)

864-876

1 reference

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describes a project that uses

16 February 2020

Cytoscape

1 reference

9 June 2022

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inferred from PubMed Central ID database lookup

cites work

Activated ClpP kills persisters and eradicates a chronic biofilm infection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4461837

Loss of mitochondrial peptidase Clpp leads to infertility, hearing loss plus growth retardation via accumulation of CLPX, mtDNA and inflammatory factors

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4461837

Mitochondrial matrix proteases as novel therapeutic targets in malignancy.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4461837

Transglutaminase 2 expression in acute myeloid leukemia: association with adhesion molecule expression and leukemic blast motility

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4461837

Perrault syndrome is caused by recessive mutations in CLPP, encoding a mitochondrial ATP-dependent chambered protease

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4461837

BCL-2 inhibition targets oxidative phosphorylation and selectively eradicates quiescent human leukemia stem cells

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4461837

Using ProHits to store, annotate, and analyze affinity purification-mass spectrometry (AP-MS) data

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4461837

An open-label, single-arm, phase 2 (PX-171-004) study of single-agent carfilzomib in bortezomib-naive patients with relapsed and/or refractory multiple myeloma

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4461837

A promiscuous biotin ligase fusion protein identifies proximal and interacting proteins in mammalian cells

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4461837

Mitochondrial processing peptidase regulates PINK1 processing, import and Parkin recruitment

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4461837

Inhibition of mitochondrial translation as a therapeutic strategy for human acute myeloid leukemia

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4461837

Abnormal expression of FLI1 protein is an adverse prognostic factor in acute myeloid leukemia

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4461837

Use of reverse phase protein microarrays to study protein expression in leukemia: technical and methodological lessons learned

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4461837

iProphet: multi-level integrative analysis of shotgun proteomic data improves peptide and protein identification rates and error estimates

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4461837

A comprehensive platform for highly multiplexed mammalian functional genetic screens

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4461837

Software pipeline and data analysis for MS/MS proteomics: the trans-proteomic pipeline

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4461837

ProHits: integrated software for mass spectrometry-based interaction proteomics

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4461837

GeneMANIA Cytoscape plugin: fast gene function predictions on the desktop

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4461837

Structural and theoretical studies indicate that the cylindrical protease ClpP samples extended and compact conformations

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4461837

Highly phosphorylated FOXO3A is an adverse prognostic factor in acute myeloid leukemia

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4461837

The matrix peptide exporter HAF-1 signals a mitochondrial UPR by activating the transcription factor ZC376.7 in C. elegans

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4461837

The ubiquitin-activating enzyme E1 as a therapeutic target for the treatment of leukemia and multiple myeloma

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4461837

A phase 1 dose escalation study of the safety and pharmacokinetics of the novel proteasome inhibitor carfilzomib (PR-171) in patients with hematologic malignancies

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4461837

Reverse phase protein array: validation of a novel proteomic technology and utility for analysis of primary leukemia specimens and hematopoietic stem cells

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4461837

Human mitochondrial ClpP is a stable heptamer that assembles into a tetradecamer in the presence of ClpX

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4461837

A mitochondrial specific stress response in mammalian cells

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4461837

Mitochondrial localization and oligomeric structure of HClpP, the human homologue of E. coli ClpP

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4461837

A human homologue of Escherichia coli ClpP caseinolytic protease: recombinant expression, intracellular processing and subcellular localization

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4461837

A genome wide shRNA screen identifies α/β hydrolase domain containing 4 (ABHD4) as a novel regulator of anoikis resistance.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4461837

SAINT: probabilistic scoring of affinity purification-mass spectrometry data

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4461837

ClpP mediates activation of a mitochondrial unfolded protein response in C. elegans

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4461837

Discovery of genes activated by the mitochondrial unfolded protein response (mtUPR) and cognate promoter elements

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4461837

Multicenter phase II study of bortezomib in patients with relapsed or refractory mantle cell lymphoma

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4461837

Bortezomib or high-dose dexamethasone for relapsed multiple myeloma

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4461837

NOD/SCID mice engineered to express human IL-3, GM-CSF and Steel factor constitutively mobilize engrafted human progenitors and compromise human stem cell regeneration

25 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26058080

12 December 2020

inferred from PubMed ID database lookup

Selective induction of apoptosis in Philadelphia chromosome-positive chronic myelogenous leukemia cells by an inhibitor of BCR–ABL tyrosine kinase, CGP 57148

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26058080

12 December 2020

inferred from PubMed ID database lookup

Development and characterization of improved β-lactone-based anti-virulence drugs targeting ClpP

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26058080

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1016/J.CCELL.2015.05.004

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26058080%20AND%20SRC:MED&resulttype=core&format=json

release_bw3ktyae7jdmjp6rqbt773uxo4

16 February 2020

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/bw3ktyae7jdmjp6rqbt773uxo4

24 November 2022

mapped directly with Wikidata item

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26058080%20AND%20SRC:MED&resulttype=core&format=json

16 February 2020

1 reference