Cancer metastasis therapeutic targets and drug discovery: emerging small-molecule protein kinase inhibitors (Q35609713)

9 August 2017

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title

Cancer metastasis therapeutic targets and drug discovery: emerging small-molecule protein kinase inhibitors (English)

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9 August 2017

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Tomi K Sawyer

1

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9 August 2017

language of work or name

English

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publication date

1 January 2004

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Expert Opinion on Investigational Drugs

9 August 2017

published in

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9 August 2017

volume

13

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9 August 2017

issue

1

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9 August 2017

page(s)

1-19

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Axis of evil: molecular mechanisms of cancer metastasis

9 August 2017

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Genomic analysis of metastasis reveals an essential role for RhoC

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Involvement of c-Src in carcinoma cell motility and metastasis

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Src kinase contributes to the metastatic spread of carcinoma cells

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Role of integrins in cell invasion and migration

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Integrin activation controls metastasis in human breast cancer

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A Ras by any other name

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The ras signaling pathway in mammary tumorigenesis and metastasis.

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RHO-GTPases and cancer

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Clinical, cellular, and molecular aspects of cancer invasion

21 January 2018

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The protein kinase complement of the human genome

21 January 2018

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Protein kinase activity associated with the avian sarcoma virus src gene product

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Protein kinases--the major drug targets of the twenty-first century?

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Receptor tyrosine kinases: the main targets for new anticancer therapy

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Receptor tyrosine kinases as target for anti-cancer therapy.

21 January 2018

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Protein kinases as targets for anticancer agents: from inhibitors to useful drugs

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SRC homology-2 inhibitors: peptidomimetic and nonpeptide

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Focal adhesion kinase as a potential target in oncology

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21 January 2018

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21 January 2018

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21 January 2018

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The phosphatidylinositol 3-Kinase AKT pathway in human cancer

21 January 2018

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Integrin-linked kinase, a promising cancer therapeutic target: biochemical and biological properties

21 January 2018

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Anticancer drugs of tomorrow: apoptotic pathways as targets for drug design

21 January 2018

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Prospects for phosphoinositide 3-kinase inhibition as a cancer treatment

21 January 2018

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A novel pathway regulating the mammalian target of rapamycin (mTOR) signaling

21 January 2018

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The rapamycin-sensitive signal transduction pathway as a target for cancer therapy

21 January 2018

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New insights into the interaction of Ras with the plasma membrane

21 January 2018

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Cell cycle targets of Ras/Raf signalling

21 January 2018

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Rationale for Ras and raf-kinase as a target for cancer therapeutics

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21 January 2018

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Role of angiogenesis in tumor growth and metastasis

21 January 2018

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Matrix metalloproteinases in tumor invasion: role for cell migration

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Complex roles of tissue inhibitors of metalloproteinases in cancer

21 January 2018

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Role of the alpha3beta1 and alpha6beta4 integrins in tumor invasion

21 January 2018

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Integrin alpha v beta 3 as a therapeutic target for blocking tumor-induced angiogenesis

21 January 2018

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Inhibitors of integrins

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21 January 2018

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Identification of endothelin–1 in the pathophysiology of metastatic adenocarcinoma of the prostate

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21 January 2018

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Development of anticancer drugs targeting the MAP kinase pathway

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New functions for the matrix metalloproteinases in cancer progression

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21 January 2018

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Nitrogen containing bisphosphonates induce apoptosis and inhibit the mevalonate pathway, impairing Ras membrane localization in prostate cancer cells

21 January 2018

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21 January 2018

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Glivec (STI571, imatinib), a rationally developed, targeted anticancer drug

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Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2.

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Surprise phase III failure for ZD1839.

21 January 2018

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Phase I and pharmacologic study of OSI-774, an epidermal growth factor receptor tyrosine kinase inhibitor, in patients with advanced solid malignancies

21 January 2018

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Src family kinases in tumor progression and metastasis

21 January 2018

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Bone-targeted 2,6,9-trisubstituted purines: novel inhibitors of Src tyrosine kinase for the treatment of bone diseases

21 January 2018

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Bone-targeted Src kinase inhibitors: novel pyrrolo- and pyrazolopyrimidine analogues

21 January 2018

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Bone-targeted pyrido[2,3-d]pyrimidin-7-ones: potent inhibitors of Src tyrosine kinase as novel antiresorptive agents

21 January 2018

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Src family kinases and HER2 interactions in human breast cancer cell growth and survival

21 January 2018

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Selective requirement for Src kinases during VEGF-induced angiogenesis and vascular permeability

21 January 2018

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The Src-selective kinase inhibitor PP1 also inhibits Kit and Bcr-Abl tyrosine kinases

21 January 2018

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4-anilino-3-quinolinecarbonitriles: an emerging class of kinase inhibitors

21 January 2018

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Pyrrolopyrimidine c-Src inhibitors reduce growth, adhesion, motility and invasion of prostate cancer cells in vitro.

21 January 2018

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21 January 2018

Identifiers

DOI

10.1517/13543784.13.1.1

1 reference

9 August 2017

1 reference