Comprehensive analysis of loops at protein-protein interfaces for macrocycle design (Q35209185)

7 August 2017

Comprehensive analysis of loops at protein-protein interfaces for macrocycle design (English)

1 reference

7 August 2017

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1

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12 June 2020

Matthew R Eshelman

4

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12 June 2020

author name string

Bradley A Sheneman

2

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12 June 2020

Timothy R Siegert

3

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12 June 2020

Joshua A Kritzer

5

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12 June 2020

publication date

20 July 2014

1 reference

7 August 2017

Nature Chemical Biology

1 reference

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12 June 2020

volume

10

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12 June 2020

issue

9

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12 June 2020

page(s)

716-722

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https://scigraph.springernature.com/pub.10.1038/nchembio.1580

12 June 2020

exact match

0 references

cites work

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Crystal-contact engineering to obtain a crystal form of the Kelch domain of human Keap1 suitable for ligand-soaking experiments

13 July 2018

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High-throughput screening AlphaScreen assay for identification of small-molecule inhibitors of ubiquitin E3 ligase SCFSkp2-Cks1

13 July 2018

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Inhibition of α-helix-mediated protein-protein interactions using designed molecules

13 July 2018

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Specific small molecule inhibitors of Skp2-mediated p27 degradation

13 July 2018

1 reference

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Getting in shape: controlling peptide bioactivity and bioavailability using conformational constraints

13 July 2018

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A phase I first-in-human trial of bardoxolone methyl in patients with advanced solid tumors and lymphomas

13 July 2018

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Structural insight into the regulation of MOF in the male-specific lethal complex and the non-specific lethal complex

13 July 2018

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Enabling large-scale design, synthesis and validation of small molecule protein-protein antagonists

13 July 2018

1 reference

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Kinetic analyses of Keap1-Nrf2 interaction and determination of the minimal Nrf2 peptide sequence required for Keap1 binding using surface plasmon resonance

13 July 2018

1 reference

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Macrocycles are great cycles: applications, opportunities, and challenges of synthetic macrocycles in drug discovery

13 July 2018

1 reference

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Structural basis for MOF and MSL3 recruitment into the dosage compensation complex by MSL1

13 July 2018

1 reference

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Systematic analysis of helical protein interfaces reveals targets for synthetic inhibitors

13 July 2018

1 reference

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Can self-inhibitory peptides be derived from the interfaces of globular protein-protein interactions?

13 July 2018

1 reference

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PyRosetta: a script-based interface for implementing molecular modeling algorithms using Rosetta

13 July 2018

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Exploring beta-sheet structure and interactions with chemical model systems

13 July 2018

1 reference

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Structural determinants of the ADAM inhibition by TIMP-3: crystal structure of the TACE-N-TIMP-3 complex

13 July 2018

1 reference

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MSDmotif: exploring protein sites and motifs

13 July 2018

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Peptidomimetics, a synthetic tool of drug discovery

13 July 2018

1 reference

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Targeting the p27 E3 ligase SCF(Skp2) results in p27- and Skp2-mediated cell-cycle arrest and activation of autophagy

13 July 2018

1 reference

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Reaching for high-hanging fruit in drug discovery at protein-protein interfaces

13 July 2018

1 reference

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Spatial chemical conservation of hot spot interactions in protein-protein complexes

13 July 2018

1 reference

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Hot spots--a review of the protein-protein interface determinant amino-acid residues

13 July 2018

1 reference

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Structure of the Keap1:Nrf2 interface provides mechanistic insight into Nrf2 signaling

13 July 2018

1 reference

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High-throughput screening for inhibitors of the Cks1-Skp2 interaction

13 July 2018

1 reference

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Structural basis of the Cks1-dependent recognition of p27(Kip1) by the SCF(Skp2) ubiquitin ligase

13 July 2018

1 reference

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Insights into protein-protein binding by binding free energy calculation and free energy decomposition for the Ras-Raf and Ras-RalGDS complexes.

13 July 2018

1 reference

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A simple physical model for binding energy hot spots in protein-protein complexes

13 July 2018

1 reference

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Three different binding sites of Cks1 are required for p27-ubiquitin ligation

13 July 2018

1 reference

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Unraveling hot spots in binding interfaces: progress and challenges

13 July 2018

1 reference

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Anatomy of hot spots in protein interfaces

13 July 2018

1 reference

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Studies of protein-protein interfaces: a statistical analysis of the hydrophobic effect

13 July 2018

1 reference

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Crystal structure of an antagonist mutant of human growth hormone, G120R, in complex with its receptor at 2.9 A resolution

13 July 2018

1 reference

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A hot spot of binding energy in a hormone-receptor interface

13 July 2018

1 reference

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Hydrogen bonding and biological specificity analysed by protein engineering

13 July 2018

1 reference

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Rational design of receptor-specific variants of human growth hormone

13 July 2018

1 reference

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Peptide inhibitors of the Keap1-Nrf2 protein-protein interaction with improved binding and cellular activity

13 July 2018

1 reference

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HotSprint: database of computational hot spots in protein interfaces

26 September 2018

1 reference

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Secondary structure based analysis and classification of biological interfaces: identification of binding motifs in protein-protein interactions.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4138238

Structure and thermodynamic characterization of the EphB4/Ephrin-B2 antagonist peptide complex reveals the determinants for receptor specificity

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4138238

Computational alanine scanning of protein-protein interfaces

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4138238

Surface, subunit interfaces and interior of oligomeric proteins

26 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25038791

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Comparison of a structural and a functional epitope

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25038791

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NCHEMBIO.1580

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25038791%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

12 June 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25038791%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25038791%20AND%20SRC:MED&resulttype=core&format=json