High-throughput screening AlphaScreen assay for identification of small-molecule inhibitors of ubiquitin E3 ligase SCFSkp2-Cks1 (Q34207491)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23589337%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

title

High-throughput screening AlphaScreen assay for identification of small-molecule inhibitors of ubiquitin E3 ligase SCFSkp2-Cks1 (English)

1 reference

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28 February 2020

6

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28 February 2020

author name string

Dana Ungermannova

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23589337%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

Junglim Lee

2

1 reference

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28 February 2020

Gan Zhang

3

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28 February 2020

H Garry Dallmann

4

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28 February 2020

Charles S McHenry

5

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28 February 2020

publication date

15 April 2013

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23589337%20AND%20SRC:MED&resulttype=core&format=json

Journal of Biomolecular Screening

28 February 2020

published in

1 reference

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28 February 2020

volume

18

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28 February 2020

issue

8

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28 February 2020

page(s)

910-920

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23589337%20AND%20SRC:MED&resulttype=core&format=json

Identification and mechanistic studies of a novel ubiquitin E1 inhibitor.

28 February 2020

cites work

1 reference

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New substructure filters for removal of pan assay interference compounds (PAINS) from screening libraries and for their exclusion in bioassays

5 July 2018

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The Cdk inhibitor p27 in human cancer: prognostic potential and relevance to anticancer therapy

5 July 2018

1 reference

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Degradation of Tob1 mediated by SCFSkp2-dependent ubiquitination

5 July 2018

1 reference

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Ubiquitin ligases: cell-cycle control and cancer

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4168015

High-throughput assays for promiscuous inhibitors.

5 July 2018

1 reference

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High-throughput screening for inhibitors of the Cks1-Skp2 interaction

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4168015

Structural basis of the Cks1-dependent recognition of p27(Kip1) by the SCF(Skp2) ubiquitin ligase

5 July 2018

1 reference

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Regulation of the polarity protein Par6 by TGFbeta receptors controls epithelial cell plasticity

5 July 2018

1 reference

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Systematic analysis and nomenclature of mammalian F-box proteins

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4168015

When protein destruction runs amok, malignancy is on the loose

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4168015

A negatively charged amino acid in Skp2 is required for Skp2-Cks1 interaction and ubiquitination of p27Kip1

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4168015

Protein-protein interactions involved in the recognition of p27 by E3 ubiquitin ligase

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4168015

Three different binding sites of Cks1 are required for p27-ubiquitin ligation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4168015

Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4168015

A Common Mechanism Underlying Promiscuous Inhibitors from Virtual and High-Throughput Screening

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4168015

The cell-cycle regulatory protein Cks1 is required for SCF(Skp2)-mediated ubiquitinylation of p27

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4168015

Regulation of the cdk inhibitor p27 and its deregulation in cancer

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4168015

CDK inhibitors: positive and negative regulators of G1-phase progression

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4168015

Ubiquitination of p27 is regulated by Cdk-dependent phosphorylation and trimeric complex formation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4168015

Tumor suppression and inhibition of aneuploid cell accumulation in human brain tumor cells by ectopic overexpression of the cyclin-dependent kinase inhibitor p27KIP1.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4168015

Luminescent oxygen channeling immunoassay: measurement of particle binding kinetics by chemiluminescence.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4168015

A CDK-independent function of mammalian Cks1: targeting of SCF(Skp2) to the CDK inhibitor p27Kip1.

5 July 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113485789

Molecular and biochemical characterization of the Skp2-Cks1 binding interface

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113485789

Ubiquitination of p27Kip1 requires physical interaction with cyclin E and probable phosphate recognition by SKP2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113485789

A recombinant adenovirus expressing p27Kip1 induces cell cycle arrest and loss of cyclin-Cdk activity in human breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113485789

Synthesis, structure-activity relationship, and p210(bcr-abl) protein tyrosine kinase activity of novel AG 957 analogs

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057113485789

Luminescent oxygen channeling assay (LOCI): sensitive, broadly applicable homogeneous immunoassay method

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23589337

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1177/1087057113485789

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23589337%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23589337%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23589337%20AND%20SRC:MED&resulttype=core&format=json