Direct inhibition of oncogenic KRAS by hydrocarbon-stapled SOS1 helices (Q35089991)

6 August 2017

Direct inhibition of oncogenic KRAS by hydrocarbon-stapled SOS1 helices (English)

1 reference

6 August 2017

James Luccarelli

4

0 references

Andrey Parkhitko

object named as

Andrey Parkhitko

2

0 references

Norbert Perrimon

object named as

Norbert Perrimon

9

0 references

Loren D. Walensky

10

object named as

Loren D Walensky

1 reference

6 August 2017

Elizaveta S Leshchiner

1

1 reference

6 August 2017

Gregory H Bird

3

1 reference

6 August 2017

Joseph A Bellairs

5

1 reference

6 August 2017

Silvia Escudero

6

1 reference

6 August 2017

Kwadwo Opoku-Nsiah

7

1 reference

6 August 2017

Marina Godes

8

1 reference

6 August 2017

language of work or name

English

0 references

publication date

26 January 2015

1 reference

Proceedings of the National Academy of Sciences of the United States of America

6 August 2017

1 reference

6 August 2017

112

1 reference

6 August 2017

6

1 reference

6 August 2017

1761-1766

1 reference

Mucosal delivery of a double-stapled RSV peptide prevents nasopulmonary infection

6 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4330742

Dragging ras back in the ring

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4330742

Hydrocarbon-stapled peptides: principles, practice, and progress

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4330742

Approach for targeting Ras with small molecules that activate SOS-mediated nucleotide exchange

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4330742

Therapeutic targeting of oncogenic K-Ras by a covalent catalytic site inhibitor

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4330742

K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4330742

Targeted disruption of the EZH2-EED complex inhibits EZH2-dependent cancer

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4330742

Using chemical shift perturbation to characterise ligand binding

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4330742

Stapled α−helical peptide drug development: A potent dual inhibitor of MDM2 and MDMX for p53-dependent cancer therapy

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4330742

Chemical synthesis of hydrocarbon-stapled peptides for protein interaction research and therapeutic targeting

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4330742

Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4330742

In silico discovery of small-molecule Ras inhibitors that display antitumor activity by blocking the Ras-effector interaction

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4330742

Inhibition of Ras-Effector Interaction by Cyclic Peptides

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4330742

Targeted disruption of the BCL9/β-catenin complex inhibits oncogenic Wnt signaling

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4330742

Discovery of Small Molecules that Bind to K-Ras and Inhibit Sos-Mediated Activation

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4330742

Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4330742

An orthosteric inhibitor of the Ras-Sos interaction

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4330742

A stapled p53 helix overcomes HDMX-mediated suppression of p53.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4330742

The HADDOCK web server for data-driven biomolecular docking

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4330742

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4330742

Ras oncogenes: split personalities

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4330742

Post-translational modifications and regulation of the RAS superfamily of GTPases as anticancer targets

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4330742

Alteration of Drosophila life span using conditional, tissue-specific expression of transgenes triggered by doxycyline or RU486/Mifepristone

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4330742

Activation of apoptosis in vivo by a hydrocarbon-stapled BH3 helix

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4330742

Structural evidence for feedback activation by Ras.GTP of the Ras-specific nucleotide exchange factor SOS

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4330742

Ectopic expression of activated Ras1 induces hyperplastic growth and increased cell death in Drosophila imaginal tissues

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4330742

Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4330742

A Drosophila SH2-SH3 adaptor protein implicated in coupling the sevenless tyrosine kinase to an activator of Ras guanine nucleotide exchange, Sos.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4330742

Molecular switch for signal transduction: structural differences between active and inactive forms of protooncogenic ras proteins

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4330742

¹H, ¹³C and ¹⁵N resonance assignment for the human K-Ras at physiological pH.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4330742

Ligand binding is the principal determinant of stability for the p21(H)-ras protein.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4330742

WeNMR: Structural Biology on the Grid

27 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.1413185112

21 January 2018

Identifiers

DOI

10.1073/PNAS.1413185112

1 reference

6 August 2017

0 references

1 reference

6 August 2017

1 reference