In silico discovery of small-molecule Ras inhibitors that display antitumor activity by blocking the Ras-effector interaction (Q27677868)

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29 February 2020

title

In silico discovery of small-molecule Ras inhibitors that display antitumor activity by blocking the Ras-effector interaction (English)

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29 February 2020

14

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29 February 2020

Takashi Kumasaka

20

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29 February 2020

Masaki Yamamoto

21

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29 February 2020

author name string

Fumi Shima

1

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29 February 2020

Yoko Yoshikawa

2

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29 February 2020

Min Ye

3

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29 February 2020

Mitsugu Araki

4

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29 February 2020

Shigeyuki Matsumoto

5

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29 February 2020

Jingling Liao

6

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29 February 2020

Lizhi Hu

7

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29 February 2020

Takeshi Sugimoto

8

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29 February 2020

Yuichi Ijiri

9

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29 February 2020

Azusa Takeda

10

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29 February 2020

Yuko Nishiyama

11

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29 February 2020

Chie Sato

12

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29 February 2020

Shin Muraoka

13

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29 February 2020

Tsutomu Osoda

15

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29 February 2020

Ken-ichiro Tsuda

16

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29 February 2020

Tomoya Miyakawa

17

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29 February 2020

Hiroaki Fukunishi

18

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29 February 2020

Jiro Shimada

19

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29 February 2020

Tohru Kataoka

22

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language of work or name

English

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publication date

29 April 2013

1 reference

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Proceedings of the National Academy of Sciences of the United States of America

29 February 2020

published in

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volume

110

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29 February 2020

page(s)

8182-8187

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29 February 2020

issue

20

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Crystal structures of the state 1 conformations of the GTP-bound H-Ras protein and its oncogenic G12V and Q61L mutants

29 February 2020

cites work

1 reference

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Discovery of Small Molecules that Bind to K-Ras and Inhibit Sos-Mediated Activation

20 March 2017

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Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity

20 March 2017

1 reference

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Structural Basis for Conformational Dynamics of GTP-bound Ras Protein

20 March 2017

1 reference

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Structural evidence for feedback activation by Ras.GTP of the Ras-specific nucleotide exchange factor SOS

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3657810

Crystal structure and functional analysis of Ras binding to its effector phosphoinositide 3-kinase gamma

20 March 2017

1 reference

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Structural basis for the interaction of Ras with RalGDS

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3657810

Regional polysterism in the GTP-bound form of the human c-Ha-Ras protein

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3657810

The 2.2 A crystal structure of the Ras-binding domain of the serine/threonine kinase c-Raf1 in complex with Rap1A and a GTP analogue

20 March 2017

1 reference

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MOLMOL: a program for display and analysis of macromolecular structures

20 March 2017

1 reference

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The guanine nucleotide-binding switch in three dimensions

20 March 2017

1 reference

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Ras oncogenes: split personalities

20 March 2017

1 reference

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Cancer. Addiction to oncogenes--the Achilles heal of cancer

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3657810

Solution structure of the state 1 conformer of GTP-bound H-Ras protein and distinct dynamic properties between the state 1 and state 2 conformers

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3657810

The Ras inhibitor farnesylthiosalicylic acid (Salirasib) disrupts the spatiotemporal localization of active Ras: a potential treatment for cancer

29 September 2017

1 reference

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Oncogene cooperation in tumor maintenance and tumor recurrence in mouse mammary tumors induced by Myc and mutant Kras

29 September 2017

1 reference

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Tumour maintenance is mediated by eNOS.

29 September 2017

1 reference

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Discovery and development of sorafenib: a multikinase inhibitor for treating cancer.

29 September 2017

1 reference

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Crystal structure of M-Ras reveals a GTP-bound "off" state conformation of Ras family small GTPases.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3657810

Essential role for oncogenic Ras in tumour maintenance

29 September 2017

1 reference

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Polylysine and CVIM sequences of K-RasB dictate specificity of prenylation and confer resistance to benzodiazepine peptidomimetic in vitro.

29 September 2017

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.1217730110

Chemical Similarity Searching

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.1217730110

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23630290

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.1217730110

2 references

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29 February 2020

ADS bibcode

2013PNAS..110.8182S

0 references

1 reference

2 references

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29 February 2020

2 references

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