Disrupting TP53 in mouse models of human cancers (Q35078774)

6 August 2017

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title

Disrupting TP53 in mouse models of human cancers (English)

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6 August 2017

John M Parant

1

1 reference

PubMed ID

12619119

6 August 2017

Guillermina Lozano

series ordinal

2

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6 August 2017

1 March 2003

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6 August 2017

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6 August 2017

21

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6 August 2017

3

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6 August 2017

321-326

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Post-translational modifications and activation of p53 by genotoxic stresses

6 August 2017

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.10186

7 January 2021

The role of p53 in tumour suppression: lessons from mouse models

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https://api.crossref.org/works/10.1002%2FHUMU.10186

7 January 2021

Adult-onset calorie restriction and fasting delay spontaneous tumorigenesis in p53-deficient mice.

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.10186

7 January 2021

Cancer phenotype correlates with constitutional TP53 genotype in families with the Li-Fraumeni syndrome.

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.10186

7 January 2021

Restoration of the tumor suppressor function to mutant p53 by a low-molecular-weight compound.

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.10186

7 January 2021

p53 transcriptional activity is essential for p53-dependent apoptosis following DNA damage

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.10186

7 January 2021

Phosphorylation of murine p53 at ser-18 regulates the p53 responses to DNA damage

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.10186

7 January 2021

Essential role for oncogenic Ras in tumour maintenance

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https://api.crossref.org/works/10.1002%2FHUMU.10186

7 January 2021

Targeted point mutations of p53 lead to dominant-negative inhibition of wild-type p53 function

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https://api.crossref.org/works/10.1002%2FHUMU.10186

7 January 2021

Gain of function mutations in p53.

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https://api.crossref.org/works/10.1002%2FHUMU.10186

7 January 2021

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

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https://api.crossref.org/works/10.1002%2FHUMU.10186

7 January 2021

Effects of genetic background on tumorigenesis in p53-deficient mice

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https://api.crossref.org/works/10.1002%2FHUMU.10186

7 January 2021

The Li-Fraumeni syndrome: an inherited susceptibility to cancer

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https://api.crossref.org/works/10.1002%2FHUMU.10186

7 January 2021

An alternatively spliced HDM2 product increases p53 activity by inhibiting HDM2

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https://api.crossref.org/works/10.1002%2FHUMU.10186

7 January 2021

Reversible tumorigenesis by MYC in hematopoietic lineages

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.10186

7 January 2021

Presence of a potent transcription activating sequence in the p53 protein

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https://api.crossref.org/works/10.1002%2FHUMU.10186

7 January 2021

Spontaneous and carcinogen-induced tumorigenesis in p53-deficient mice.

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.10186

7 January 2021

DNA damage-induced activation of p53 by the checkpoint kinase Chk2

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.10186

7 January 2021

Tumor spectrum analysis in p53-mutant mice

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https://api.crossref.org/works/10.1002%2FHUMU.10186

7 January 2021

MdmX protects p53 from Mdm2-mediated degradation

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.10186

7 January 2021

A transactivation-deficient mouse model provides insights into Trp53 regulation and function

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.10186

7 January 2021

Somatic activation of the K-ras oncogene causes early onset lung cancer in mice

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.10186

7 January 2021

Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.10186

7 January 2021

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.10186

7 January 2021

p53: puzzle and paradigm

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.10186

7 January 2021

Development of spontaneous mammary tumors in BALB/c p53 heterozygous mice. A model for Li-Fraumeni syndrome

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.10186

7 January 2021

Several hydrophobic amino acids in the p53 amino-terminal domain are required for transcriptional activation, binding to mdm-2 and the adenovirus 5 E1B 55-kD protein

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.10186

7 January 2021

High metastatic potential in mice inheriting a targeted p53 missense mutation

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.10186

7 January 2021

p53 status and the efficacy of cancer therapy in vivo

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.10186

7 January 2021

Mouse models dissect the role of p53 in cancer and development

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.10186

7 January 2021

myc function and regulation

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.10186

7 January 2021

The p53 and Mdm2 families in cancer.

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.10186

7 January 2021

Mdm4 (Mdmx) regulates p53-induced growth arrest and neuronal cell death during early embryonic mouse development

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.10186

7 January 2021

Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.10186

7 January 2021

A male germ cell tumor-susceptibility-determining locus, pgct1, identified on murine chromosome 13

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.10186

7 January 2021

Amplification of a gene encoding a p53-associated protein in human sarcomas

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.10186

7 January 2021

Rescue of embryonic lethality in Mdm4-null mice by loss of Trp53 suggests a nonoverlapping pathway with MDM2 to regulate p53

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.10186

7 January 2021

Transcriptional activation by wild-type but not transforming mutants of the p53 anti-oncogene

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.10186

7 January 2021

DNA damage-inducible phosphorylation of p53 at N-terminal sites including a novel site, Ser20, requires tetramerization

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.10186

7 January 2021

p53-dependent apoptosis suppresses tumor growth and progression in vivo

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.10186

7 January 2021

Critical role for Ser20 of human p53 in the negative regulation of p53 by Mdm2.

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.10186

7 January 2021

Cancer modeling in the modern era: progress and challenges

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.10186

7 January 2021

Retention of wild-type p53 in tumors from p53 heterozygous mice: reduction of p53 dosage can promote cancer formation

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.10186

7 January 2021

Mutation of mouse p53 Ser23 and the response to DNA damage

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.10186

7 January 2021

The ons and offs of inducible transgenic technology: a review.

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.10186

7 January 2021

Identifiers

DOI

10.1002/HUMU.10186

1 reference

6 August 2017

1 reference

PubMed ID

12619119