New therapeutics that antagonize endothelin: promises and frustrations (Q35013988)

5 August 2017

1 reference

title

New therapeutics that antagonize endothelin: promises and frustrations (English)

1 reference

5 August 2017

Giuseppe Remuzzi

1

0 references

Ariela Benigni

series ordinal

3

object named as

Ariela Benigni

1 reference

5 August 2017

2

Norberto Perico

1 reference

5 August 2017

1 December 2002

1 reference

Nature Reviews Drug Discovery

5 August 2017

1 reference

5 August 2017

1

1 reference

5 August 2017

986-1001

1 reference

5 August 2017

12

1 reference

https://scigraph.springernature.com/pub.10.1038/nrd962

5 August 2017

0 references

cites work

A novel potent vasoconstrictor peptide produced by vascular endothelial cells

1 reference

Hypoxia releases a vasoconstrictor substance from the canine vascular endothelium.

31 March 2020

1 reference

31 March 2020

1 reference

The human endothelin family: three structurally and pharmacologically distinct isopeptides predicted by three separate genes

31 March 2020

1 reference

cDNA cloning and chromosomal assignment of the endothelin 2 gene: Vasoactive intestinal contractor peptide is rat endothelin 2

31 March 2020

1 reference

Natriuretic peptides inhibit angiotensin II-induced proliferation of rat cardiac fibroblasts by blocking endothelin-1 gene expression

31 March 2020

1 reference

Endothelin receptor subtype B mediates autoinduction of endothelin-1 in rat mesangial cells

31 March 2020

1 reference

Physiological fluid shear stress causes downregulation of endothelin-1 mRNA in bovine aortic endothelium

31 March 2020

1 reference

Angiotensin II increases vascular and renal endothelin-1 and functional endothelin converting enzyme activity in vivo: role of ETA receptors for endothelin regulation

31 March 2020

1 reference

Endothelin-1 is an autocrine/paracrine factor in the mechanism of angiotensin II-induced hypertrophy in cultured rat cardiomyocytes

31 March 2020

1 reference

Stimulatory interaction between vascular endothelial growth factor and endothelin-1 on each gene expression.

31 March 2020

1 reference

Endothelin-1 modulates the expression of adhesion molecules on fibroblast-like synovial cells (FLS)

31 March 2020

1 reference

Release of endothelin from the porcine aorta. Inhibition by endothelium-derived nitric oxide

31 March 2020

1 reference

Heterogeneity of smooth muscle myosin heavy chain expression at the single cell level

31 March 2020

1 reference

Secretion of endothelin-1 and endothelin-3 by human cultured vascular smooth muscle cells

31 March 2020

1 reference

Endothelin antagonists in renal disease

31 March 2020

1 reference

Endothelin receptor antagonists prevent parathyroid cell proliferation caused by hypocalcemia in rats

31 March 2020

1 reference

Human endothelial cell storage granules: a novel intracellular site for isoforms of the endothelin-converting enzyme

31 March 2020

1 reference

Evidence using immunoelectron microscopy for regulated and constitutive pathways in the transport and release of endothelin.

31 March 2020

1 reference

31 March 2020

Endothelin antagonists

1 reference

Organization of the gene encoding the human endothelin-converting enzyme (ECE-1)

31 March 2020

1 reference

Human endothelin-converting enzyme (ECE-1): three isoforms with distinct subcellular localizations

31 March 2020

1 reference

ECE-1: a membrane-bound metalloprotease that catalyzes the proteolytic activation of big endothelin-1

31 March 2020

1 reference

A fourth isoform of endothelin-converting enzyme (ECE-1) is generated from an additional promoter molecular cloning and characterization

31 March 2020

1 reference

Urinary endothelin: a possible biological marker of renal damage

31 March 2020

1 reference

A soluble protease identified from rat kidney degrades endothelin-1 but not proendothelin-1

31 March 2020

1 reference

Endothelin 1 hydrolysis by rat kidney membranes

31 March 2020

1 reference

The Enterococcus faecalis extracellular metalloendopeptidase (EC 3.4.24.30; coccolysin) inactivates human endothelin at bonds involving hydrophobic amino acid residues

31 March 2020

1 reference

High density lipoproteins stimulate the production and secretion of endothelin-1 from cultured bovine aortic endothelial cells

31 March 2020

1 reference

Cloning and expression of a cDNA encoding an endothelin receptor

31 March 2020

1 reference

Cloning of a cDNA encoding a non-isopeptide-selective subtype of the endothelin receptor

31 March 2020

1 reference

International Union of Pharmacology. XXIX. Update on endothelin receptor nomenclature

31 March 2020

1 reference

Contribution of endogenous generation of endothelin-1 to basal vascular tone

31 March 2020

1 reference

Endothelin-A receptor antagonist-mediated vasodilatation is attenuated by inhibition of nitric oxide synthesis and by endothelin-B receptor blockade.

31 March 2020

1 reference

Venous smooth muscle contains vasoconstrictor ETB-like receptors

31 March 2020

1 reference

Clearance of circulating endothelin-1 by ETB receptors in rats

31 March 2020

1 reference

Endothelin-1 stimulates its own synthesis in human endothelial cells

31 March 2020

1 reference

Characterization of three non-peptide endothelin receptor ligands using human cloned ETA and ETB receptors

31 March 2020

1 reference

The endothelin family: an overview

31 March 2020

1 reference

Biological profiles of highly potent novel endothelin antagonists selective for the ETA receptor

31 March 2020

1 reference

The pharmacology of bosentan

31 March 2020

1 reference

Hypertension associated with endothelin-secreting malignant hemangioendothelioma

31 March 2020

1 reference

Prevalence of Hypertension in the US Adult Population : Results From the Third National Health and Nutrition Examination Survey, 1988-1991

31 March 2020

1 reference

Plasma endothelin levels in hypertension and chronic renal failure

31 March 2020

1 reference

A sensitive radioimmunoassay measuring endothelin-like immunoreactivity in human plasma: comparison of levels in patients with essential hypertension and normotensive control subjects

31 March 2020

1 reference

31 March 2020

1 reference

Endothelin in renovascular and essential hypertension

31 March 2020

1 reference

Racial differences in plasma endothelin-1 concentrations in individuals with essential hypertension

31 March 2020

1 reference

The effect of an endothelin-receptor antagonist, bosentan, on blood pressure in patients with essential hypertension. Bosentan Hypertension Investigators

31 March 2020

1 reference

Darusentan: an effective endothelinA receptor antagonist for treatment of hypertension

31 March 2020

1 reference

Different contributions of endothelin-A and endothelin-B receptors in the pathogenesis of deoxycorticosterone acetate-salt-induced hypertension in rats

31 March 2020

1 reference

The role of ETB receptors in normotensive and hypertensive rats as revealed by the non-peptide selective ETB receptor antagonist Ro 46-8443

31 March 2020

1 reference

Endothelin-A receptor antagonism attenuates the hypertension and renal injury in Dahl salt-sensitive rats.

31 March 2020

1 reference

Structure and function of small arteries in salt-induced hypertension: effects of chronic endothelin-subtype-A-receptor blockade

31 March 2020

1 reference

ET(A) receptor blockade prevents increased tissue endothelin-1, vascular hypertrophy, and endothelial dysfunction in salt-sensitive hypertension

31 March 2020

1 reference

Racial and gender differences in endothelin-1.

31 March 2020

1 reference

The effect of regulation of high blood pressure on plasma endothelin-1 levels in blacks with hypertension

31 March 2020

1 reference

Racial differences in endothelin-1 at rest and in response to acute stress in adolescent males

31 March 2020

1 reference

31 March 2020

Renal-artery stenosis

1 reference

Vascular hypertrophy and remodeling in secondary hypertension

31 March 2020

1 reference

Treatment of primary pulmonary hypertension -- the next generation

31 March 2020

1 reference

The effect of high doses of calcium-channel blockers on survival in primary pulmonary hypertension

31 March 2020

1 reference

Endothelin and pulmonary hypertension

31 March 2020

1 reference

Hemodynamic effects of Bosentan, an endothelin receptor antagonist, in patients with pulmonary hypertension

31 March 2020

1 reference

Effects of the dual endothelin-receptor antagonist bosentan in patients with pulmonary hypertension: a randomised placebo-controlled study

31 March 2020

1 reference

Bosentan therapy for pulmonary arterial hypertension

31 March 2020

1 reference

A comparison of continuous intravenous epoprostenol (prostacyclin) with conventional therapy for primary pulmonary hypertension

31 March 2020

1 reference

Survival in primary pulmonary hypertension: the impact of epoprostenol therapy.

31 March 2020

1 reference

Sildenafil in primary pulmonary hypertension

31 March 2020

1 reference

Endothelin receptor antagonists in congestive heart failure: a new therapeutic principle for the future?

31 March 2020

1 reference

Plasma endothelin in chronic heart failure

31 March 2020

1 reference

Increased plasma concentrations of endothelin in congestive heart failure in humans

31 March 2020

1 reference

Endothelin in human congestive heart failure

31 March 2020

1 reference

Comparison of plasma neurohormones in congestive heart failure patients with atrial fibrillation versus patients with sinus rhythm.

31 March 2020

1 reference

Prognostic impact of big endothelin-1 plasma concentrations compared with invasive hemodynamic evaluation in severe heart failure

31 March 2020

1 reference

New therapeutic options in congestive heart failure: Part I.

31 March 2020

1 reference

Clinical experience with endothelin receptor antagonists in chronic heart failure

31 March 2020

1 reference

Short-term oral endothelin-receptor antagonist therapy in conventionally treated patients with symptomatic severe chronic heart failure.

31 March 2020

1 reference

Do results of the ENABLE (Endothelin Antagonist Bosentan for Lowering Cardiac Events in Heart Failure) study spell the end for non-selective endothelin antagonism in heart failure?

31 March 2020

1 reference

Clinical Trials Update: CAPRICORN, COPERNICUS, MIRACLE, STAF, RITZ-2, RECOVER and RENAISSANCE and cachexia and cholesterol in heart failure. Highlights of the Scientific Sessions of the American College of Cardiology, 2001.

31 March 2020

1 reference

Clinical trials update: highlights of the scientific sessions of the American Heart Association year 2000: Val HeFT, COPERNICUS, MERIT, CIBIS-II, BEST, AMIOVIRT, V-MAC, BREATHE, HEAT, MIRACL, FLORIDA, VIVA and the first human cardiac skeletal muscle

31 March 2020

1 reference

The renoprotective potential of endothelin receptor antagonists

31 March 2020

1 reference

Endothelins in the kidney: physiology and pathophysiology

31 March 2020

1 reference

Research on renal endothelin in proteinuric nephropathies dictates novel strategies to prevent progression

31 March 2020

1 reference

A specific endothelin subtype A receptor antagonist protects against injury in renal disease progression

31 March 2020

1 reference

Blocking both type A and B endothelin receptors in the kidney attenuates renal injury and prolongs survival in rats with remnant kidney

31 March 2020

1 reference

Renoprotective effect of contemporary blocking of angiotensin II and endothelin-1 in rats with membranous nephropathy.

31 March 2020

1 reference

Effect of a specific endothelin receptor A antagonist on mRNA levels for extracellular matrix components and growth factors in diabetic glomeruli

31 March 2020

1 reference

Unselective inhibition of endothelin receptors reduces renal dysfunction in experimental diabetes

31 March 2020

1 reference

Effect of a specific endothelin A receptor antagonist on murine lupus nephritis

31 March 2020

1 reference

A role for endothelin in the maintenance of post-ischaemic renal failure in the rat

31 March 2020

1 reference

Upregulation of renal endothelin receptors in glycerol-induced acute renal failure in the rat

31 March 2020

1 reference

Protective effect of a selective endothelin receptor antagonist, BQ-123, in ischemic acute renal failure in rats

31 March 2020

1 reference

Effects of a new endothelin antagonist, TAK-044, on post-ischemic acute renal failure in rats

31 March 2020

1 reference

Renal hemodynamics and pharmacokinetics of bosentan with and without cyclosporine A

31 March 2020

1 reference

Calcium channel blockers protect transplant patients from cyclosporine-induced daily renal hypoperfusion

31 March 2020

1 reference

Plasma endothelin immunoreactivity in liver disease and the hepatorenal syndrome

31 March 2020

1 reference

Endothelin is an important determinant of renal function in a rat model of acute liver and renal failure

31 March 2020

1 reference

Amelioration of hepatorenal syndrome with selective endothelin-A antagonist

31 March 2020

1 reference

Circulating and tissue endothelin immunoreactivity in advanced atherosclerosis

31 March 2020

1 reference

Endothelin in atherosclerosis: importance of risk factors and therapeutic implications

31 March 2020

1 reference

Angiotensin II increases tissue endothelin and induces vascular hypertrophy: reversal by ET(A)-receptor antagonist

31 March 2020

1 reference

Endothelin ETA receptor blockade restores NO-mediated endothelial function and inhibits atherosclerosis in apolipoprotein E-deficient mice

31 March 2020

1 reference

Endothelin-receptor antagonists: current and future perspectives

31 March 2020

1 reference

Systemic Blockade of the Endothelin-B Receptor Increases Peripheral Vascular Resistance in Healthy Men

31 March 2020

1 reference

ET(B) receptor protects the tubulointerstitium in experimental thrombotic microangiopathy

31 March 2020

1 reference

Salt-sensitive hypertension in endothelin-B receptor-deficient rats

31 March 2020

1 reference

Endothelin B receptors are functionally important in mediating vasoconstriction in the systemic circulation in patients with left ventricular systolic dysfunction.

31 March 2020

1 reference

Endothelin blockers and renal protection: a new strategy to prevent end-organ damage in cardiovascular disease?

31 March 2020

1 reference

Combined angiotensin and endothelin receptor blockade attenuates adverse cardiac remodeling post-myocardial infarction in the rat: possible role of transforming growth factor beta(1).

31 March 2020

1 reference

Cardioprotection by long-term ET(A) receptor blockade and ACE inhibition in rats with congestive heart failure: mono- versus combination therapy

31 March 2020

1 reference

Long-term survival and hemodynamics after endothelin-a receptor antagonism and angiotensin-converting enzyme inhibition in rats with chronic heart failure: monotherapy versus combination therapy.

31 March 2020

1 reference

Antihypertensive effects of a mixed endothelin-A- and -B-receptor antagonist, J-104132, were augmented in the presence of an AT1 -receptor antagonist, MK-954

31 March 2020

1 reference

Chronic renal diseases: renoprotective benefits of renin-angiotensin system inhibition

31 March 2020

1 reference

Progression, remission, regression of chronic renal diseases

31 March 2020

1 reference

Discovery of N-isoxazolyl biphenylsulfonamides as potent dual angiotensin II and endothelin A receptor antagonists

31 March 2020

1 reference

Pathophysiological role of endothelin revealed by the first orally active endothelin receptor antagonist

31 March 2020

1 reference

Reciprocal regulation of endothelin-1 and nitric oxide: relevance in the physiology and pathology of the cardiovascular system.

31 March 2020

1 reference

Pressor effects of circulating endothelin are limited by its removal in the pulmonary circulation and by the release of prostacyclin and endothelium-derived relaxing factor

31 March 2020

1 reference

Integrated cardiac, renal, and endocrine actions of endothelin

31 March 2020

1 reference

Endothelin-1 induces hypertrophy with enhanced expression of muscle-specific genes in cultured neonatal rat cardiomyocytes

31 March 2020

1 reference

Endothelin: a potent stimulus of atrial natriuretic peptide secretion by superfused rat atria and its dependency on calcium

31 March 2020

1 reference

Potent selective vasoconstrictor effects of endothelin in the pig kidney in vivo.

31 March 2020

1 reference

Mesangial cell, glomerular and renal vascular responses to endothelin in the rat kidney. Elucidation of signal transduction pathways

31 March 2020

1 reference

Endothelin's biphasic effect on fluid absorption in the proximal straight tubule and its inhibitory cascade

31 March 2020

1 reference

Endothelin-1 stimulates the Na+/H+ and Na+/HCO3- transporters in rabbit renal cortex

31 March 2020

1 reference

Endothelin, a peptide inhibitor of Na(+)-K(+)-ATPase in intact renaltubular epithelial cells

31 March 2020

1 reference

Cystine dimethyl ester reduces the forces driving sodium-dependent transport in LLC-PK1 cells

31 March 2020

1 reference

Role of endothelin-1 in lung disease

31 March 2020

1 reference

Endothelin-1 promotes mitogenesis in airway smooth muscle cells

31 March 2020

1 reference

Endothelin receptor distribution and function in the airways

31 March 2020

1 reference

The endothelins in the pulmonary system

31 March 2020

1 reference

EndothelinB (ETB) receptor-activated potentiation of cholinergic nerve-mediated contraction in human bronchus

31 March 2020

1 reference

Vasoconstrictive responses elicited by endothelin in bovine cerebral arteries

31 March 2020

1 reference

Endothelin Receptors on Cultured Fetal Rat Diencephalic Glia

31 March 2020

1 reference

Effect of endothelin-1 on release of arginine-vasopressin from perifused rat hypothalamus

31 March 2020

1 reference

Endothelin-3 inhibits prolactin and stimulates LH, FSH and TSH secretion from pituitary cell culture

31 March 2020

1 reference

Endothelin as an autocrine factor in the regulation of parathyroid cells

31 March 2020

1 reference

Regional vasodilation to endothelin-1 is mediated by a non-ETA receptor subtype in the anaesthetized rat: effect of BQ-123 on systemic haemodynamic responses

31 March 2020

1 reference

Inhibition of myocardial endothelin pathway improves long-term survival in heart failure

31 March 2020

1 reference

The endothelin-1 receptor antagonist BQ-123 reduces infarct size in a canine model of coronary occlusion and reperfusion.

31 March 2020

1 reference

Effects of a selective endothelin A-receptor antagonist, BQ-123, in salt-loaded stroke-prone spontaneously hypertensive rats

31 March 2020

1 reference

Comparison of the effects of selective endothelin ETA and ETB receptor antagonists in congestive heart failure

31 March 2020

1 reference

Different secretion patterns of atrial natriuretic peptide and brain natriuretic peptide in patients with congestive heart failure.

31 March 2020

1 reference

Pharmacology of a non-selective ETA and ETB receptor antagonist, TAK-044 and the inhibition of myocardial infarct size in rats

31 March 2020

1 reference

Improvement of renal dysfunction in dogs with endotoxemia by a nonselective endothelin receptor antagonist.

31 March 2020

1 reference

Endothelin antagonists for hypertension and renal disease.

31 March 2020

1 reference

Effect of chronic treatment with two different ET(A) selective endothelin receptor antagonists on blood pressure and small artery structure of deoxycorticosterone acetate (DOCA)-salt hypertensive rats.

31 March 2020

1 reference

Endothelin-A receptor antagonist combined with hydralazine improves survival and renal function in hypertensive rats

31 March 2020

1 reference

Chronic ETA receptor blockade attenuates cardiac hypertrophy independently of blood pressure effects in renovascular hypertensive rats

31 March 2020

1 reference

The ET(A)-Receptor Antagonist LU 135252 Prevents the Progression of Established Pulmonary Hypertension Induced by Monocrotaline in Rats

31 March 2020

1 reference

Improvement of postischemic acute renal failure with the novel orally active endothelin-A receptor antagonist LU 135252 in the rat.

31 March 2020

1 reference

Nephroprotection of an ET(A)-receptor blocker (LU 135252) in salt-loaded uninephrectomized stroke-prone spontaneously hypertensive rats

31 March 2020

1 reference

Chronic hypoxia-induced cardiopulmonary changes in three rat strains: inhibition by the endothelin receptor antagonist SB 217242

31 March 2020

1 reference

Application of serial in vivo magnetic resonance imaging to evaluate the efficacy of endothelin receptor antagonist SB 217242 in the rat carotid artery model of neointima formation

31 March 2020

1 reference

Endothelin-1 and right-sided heart failure in rats: effects of an endothelin receptor antagonist on the failing right ventricle.

31 March 2020

1 reference

The effects of endothelin-A receptor blockade during the progression of pacing-induced congestive heart failure.

31 March 2020

1 reference

Effect of a nonselective endothelin antagonist on vascular remodeling in deoxycorticosterone acetate-salt hypertensive rats. Evidence for a role of endothelin in vascular hypertrophy

31 March 2020

1 reference

Renal and vascular effects of chronic endothelin receptor antagonism in malignant hypertensive rats

31 March 2020

1 reference

Effects of endothelin receptor inhibition on cerebral arterioles in hypertensive rats

31 March 2020

1 reference

Endothelin-receptor antagonist bosentan prevents and reverses hypoxic pulmonary hypertension in rats

31 March 2020

1 reference

Role of endothelin in the maintenance of blood pressure in conscious rats with chronic heart failure. Acute effects of the endothelin receptor antagonist Ro 47-0203 (bosentan)

31 March 2020

1 reference

Role of endogenous endothelin in chronic heart failure: effect of long-term treatment with an endothelin antagonist on survival, hemodynamics, and cardiac remodeling

31 March 2020

1 reference

Beneficial effects of the endothelin receptor antagonist bosentan on myocardial and endothelial injury following ischaemia/reperfusion in the rat

31 March 2020

1 reference

Renal endothelin system in obstructive jaundice: its role in impaired renal function of bile-duct ligated rats

31 March 2020

1 reference

Bosentan, an orally active endothelin antagonist: effect on the renal response to contrast media

31 March 2020

1 reference

An orally active ETA/ETB receptor antagonist ameliorates proteinuria and glomerular lesions in rats with proliferative nephritis

31 March 2020

1 reference

The role of endothelin in experimental cerebral vasospasm

31 March 2020

1 reference

The effect of bosentan, a new potent endothelin receptor antagonist, on the pathogenesis of cerebral vasospasm

31 March 2020

1 reference

Endothelin antagonists: substituted mesitylcarboxamides with high potency and selectivity for ET(A) receptors

31 March 2020

1 reference

Attenuation of pulmonary vascular hypertension and cardiac hypertrophy with sitaxsentan sodium, an orally active ET(A) receptor antagonist

31 March 2020

1 reference

Pharmacology of endothelin receptor antagonists ABT-627, ABT-546, A-182086 and A-192621: ex vivo and in vivo studies.

31 March 2020

1 reference

Different roles of two types of endothelin receptors in partial ablation-induced chronic renal failure in rats

31 March 2020

1 reference

Profiles of an intravenously available endothelin A-receptor antagonist, S-0139, for preventing cerebral vasospasm in a canine two-hemorrhage model

31 March 2020

1 reference

Combined antagonism of endothelin A/B receptors links endothelin to vasoconstriction whereas angiotensin II effects fibrosis. Studies in chronic cyclosporine nephrotoxicity in rats

31 March 2020

1 reference

Effect of the endothelin receptor antagonist, SB 209670 on cyclosporine-induced nephrotoxicity

31 March 2020

1 reference

Early-onset but not late-onset endothelin-A-receptor blockade can modulate hypertension, cerebral edema, and proteinuria in stroke-prone hypertensive rats.

31 March 2020

1 reference

Plasma endothelin in human essential hypertension

31 March 2020

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NRD962

1 reference

5 August 2017

1 reference

PubMed ID

12461520