ECE-1: a membrane-bound metalloprotease that catalyzes the proteolytic activation of big endothelin-1 (Q24317184)

metalloendopeptidase activity

GOA release 2020-03-11

1 reference

Endothelin converting enzyme 1

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

author name string

D Xu

1

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N Emoto

2

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A Giaid

3

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C Slaughter

4

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S Kaw

5

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D deWit

6

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M Yanagisawa

Identification and characterization of endothelin converting activity from EAHY 926 cells: evidence for the physiologically relevant human enzyme

7

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language of work or name

English

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publication date

12 August 1994

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published in

Cell

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volume

78

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issue

3

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page(s)

473-85

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cites work

1 reference

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A novel endothelin ETA receptor antagonist, BQ-485, and its preventive effect on experimental cerebral vasospasm in dogs

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Topographical localisation of endothelin mRNA and peptide immunoreactivity in neurones of the human brain

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Internal protein sequence analysis: enzymatic digestion for less than 10 micrograms of protein bound to polyvinylidene difluoride or nitrocellulose membranes

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Phosphoramidon inhibits the intracellular conversion of big endothelin-1 to endothelin-1 in cultured endothelial cells

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Concomitant expression of receptor subtype and isopeptide of endothelin by human adrenal gland

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Molecular cloning and amino acid sequence of human enkephalinase (neutral endopeptidase).

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A sandwich-type enzyme immunoassay to detect immunoreactive big-endothelin-1 in plasma

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Antihypertensive effect of a newly synthesized endothelin antagonist, BQ-123, in a genetic hypertensive model

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Receptor binding affinity and biological activity of C-terminal elongated forms of endothelin-1

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The discovery of sulfonamide endothelin antagonists and the development of the orally active ETA antagonist 5-(dimethylamino)-N-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulf onamide.

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A novel potent vasoconstrictor peptide produced by vascular endothelial cells

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Cloning and expression of a cDNA encoding an endothelin receptor

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Cloning of a cDNA encoding a non-isopeptide-selective subtype of the endothelin receptor

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Pathophysiological role of endothelin revealed by the first orally active endothelin receptor antagonist

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Elevated blood pressure and craniofacial abnormalities in mice deficient in endothelin-1

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A specific endothelin subtype A receptor antagonist protects against injury in renal disease progression

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Effects of BQ-123 on renal function and acute cyclosporine-induced renal dysfunction

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Evolutionary families of peptidases

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Endothelin-converting enzymes and other families of metallo-endopeptidases

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Expression of endothelin-1 in the lungs of patients with pulmonary hypertension.

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The endothelin-1 receptor antagonist BQ-123 reduces infarct size in a canine model of coronary occlusion and reperfusion

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Endothelin‐converting enzymes

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Synthesis of endothelin-1 analogues, endothelin-3, and sarafotoxin S6b: structure-activity relationships.

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Big endothelin-1 structure important for specific processing by endothelin-converting enzyme of bovine endothelial cells

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Mammalian paired basic amino acid convertases of prohormones and proproteins

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High-efficiency transformation of mammalian cells by plasmid DNA

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The endothelin system. A new target for therapeutic intervention

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Messenger RNA expression and synthesis of endothelin-1 along rat nephron segments

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Endothelin-1 is an autocrine/paracrine factor in the mechanism of angiotensin II-induced hypertrophy in cultured rat cardiomyocytes

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Reversal of postischemic acute renal failure with a selective endothelinA receptor antagonist in the rat

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WS79089A, B and C, new endothelin converting enzyme inhibitors isolated from Streptosporangium roseum. No. 79089. Taxonomy, fermentation, isolation, physico-chemical properties and biological activities.

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