Blockade of class IB phosphoinositide-3 kinase ameliorates obesity-induced inflammation and insulin resistance (Q34804886)

4 August 2017

Blockade of class IB phosphoinositide-3 kinase ameliorates obesity-induced inflammation and insulin resistance (English)

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4 August 2017

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1 reference

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Yoshitaka Nishikawa

12

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Kotaro Yoshimura

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Kotaro Yoshimura

14

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Kohjiro Ueki

2

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Kohjiro Ueki

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4 August 2017

22

Takashi Kadowaki

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4 August 2017

Naoki Kobayashi

1

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4 August 2017

Yukiko Okazaki

3

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4 August 2017

Aya Iwane

4

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4 August 2017

Naoto Kubota

5

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4 August 2017

Mitsuru Ohsugi

6

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4 August 2017

Motoharu Awazawa

7

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4 August 2017

Masatoshi Kobayashi

8

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4 August 2017

Takayoshi Sasako

9

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4 August 2017

Kazuma Kaneko

10

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4 August 2017

Miho Suzuki

11

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4 August 2017

Kazuo Hara

13

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4 August 2017

Isao Koshima

15

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4 August 2017

Susumu Goyama

16

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4 August 2017

Koji Murakami

17

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4 August 2017

Junko Sasaki

18

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4 August 2017

Ryozo Nagai

19

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4 August 2017

Mineo Kurokawa

20

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4 August 2017

Takehiko Sasaki

21

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4 August 2017

language of work or name

English

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publication date

21 March 2011

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Proceedings of the National Academy of Sciences of the United States of America

4 August 2017

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4 August 2017

108

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4 August 2017

5753-5758

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4 August 2017

14

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CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity

4 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3078379

CXC ligand 5 is an adipose-tissue derived factor that links obesity to insulin resistance

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3078379

Role of CC chemokine receptor 2 in bone marrow cells in the recruitment of macrophages into obese adipose tissue.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3078379

Phenotypic switching of adipose tissue macrophages with obesity is generated by spatiotemporal differences in macrophage subtypes

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3078379

Evi-1 is a critical regulator for hematopoietic stem cells and transformed leukemic cells.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3078379

FSP27 contributes to efficient energy storage in murine white adipocytes by promoting the formation of unilocular lipid droplets

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3078379

The p110beta isoform of phosphoinositide 3-kinase signals downstream of G protein-coupled receptors and is functionally redundant with p110gamma.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3078379

Fat and beyond: the diverse biology of PPARgamma

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3078379

Hepatic steatosis in leptin-deficient mice is promoted by the PPARgamma target gene Fsp27.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3078379

Targeting phosphoinositide 3-kinase: moving towards therapy

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3078379

Lymphocyte cell motility: the twisting, turning tale of phosphoinositide 3-kinase

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3078379

Evaluation and management of obesity-related nonalcoholic fatty liver disease

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3078379

Human adipose tissue macrophages are of an anti-inflammatory phenotype but capable of excessive pro-inflammatory mediator production.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3078379

Macrophage-specific PPARgamma controls alternative activation and improves insulin resistance

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3078379

Nonalcoholic fatty liver disease: from pathogenesis to patient care.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3078379

Deletion of the phosphoinositide 3-kinase p110gamma gene attenuates murine atherosclerosis

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3078379

Obesity induces a phenotypic switch in adipose tissue macrophage polarization

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3078379

Abdominal obesity and metabolic syndrome

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3078379

Mechanisms linking obesity to insulin resistance and type 2 diabetes

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3078379

PI3Kgamma inhibition: towards an 'aspirin of the 21st century'?

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3078379

Overexpression of monocyte chemoattractant protein-1 in adipose tissues causes macrophage recruitment and insulin resistance

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3078379

MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3078379

Epidemiologic and economic consequences of the global epidemics of obesity and diabetes

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3078379

CCR2 modulates inflammatory and metabolic effects of high-fat feeding

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3078379

Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3078379

Obesity is associated with macrophage accumulation in adipose tissue

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3078379

Alternative activation of macrophages

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3078379

Increased insulin sensitivity in mice lacking p85beta subunit of phosphoinositide 3-kinase

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3078379

Central role for G protein-coupled phosphoinositide 3-kinase gamma in inflammation.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3078379

Function of PI3Kgamma in thymocyte development, T cell activation, and neutrophil migration

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3078379

Inhibition of CCR2 ameliorates insulin resistance and hepatic steatosis in db/db mice.

8 July 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1016430108

Inhibition of the chemokine (C-C motif) ligand 2/chemokine (C-C motif) receptor 2 pathway attenuates hyperglycaemia and inflammation in a mouse model of hepatic steatosis and lipoatrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1016430108

CC chemokine and CC chemokine receptor profiles in visceral and subcutaneous adipose tissue are altered in human obesity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1016430108

Disruption of CXC motif chemokine ligand-14 in mice ameliorates obesity-induced insulin resistance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1016430108

Dynamic functional relay between insulin receptor substrate 1 and 2 in hepatic insulin signaling during fasting and feeding

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1016430108

Blockade of PI3Kgamma suppresses joint inflammation and damage in mouse models of rheumatoid arthritis.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3078379

PI3Kgamma inhibition blocks glomerulonephritis and extends lifespan in a mouse model of systemic lupus

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3078379

PPARγ Activation Primes Human Monocytes into Alternative M2 Macrophages with Anti-inflammatory Properties

26 October 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1016430108

PI(3)Kγ has an important context-dependent role in neutrophil chemokinesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1016430108

Control of cell polarity and motility by the PtdIns(3,4,5)P3 phosphatase SHIP1

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1016430108

21 January 2018

Identifiers

DOI

10.1073/PNAS.1016430108

1 reference

4 August 2017

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4 August 2017

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