PI3Kgamma inhibition: towards an 'aspirin of the 21st century'? (Q28201583)

Nature Reviews Drug Discovery

Europe PubMed Central

title

PI3Kgamma inhibition: towards an 'aspirin of the 21st century'? (English)

0 references

1 reference

Thomas Rückle

1

0 references

Matthias K Schwarz

series ordinal

2

0 references

Christian Rommel

series ordinal

3

0 references

language of work or name

English

0 references

publication date

November 2006

0 references

published in

0 references

volume

5

0 references

page(s)

903-18

0 references

issue

11

0 references

cites work

Phosphoinositide 3-kinase in disease: timing, location, and scaffolding

1 reference

A new grammar for drug discovery

31 March 2020

1 reference

The phosphoinositide 3-kinase pathway

31 March 2020

1 reference

The role of phosphoinositide 3-kinase lipid products in cell function

31 March 2020

1 reference

Involvement of phosphoinositide 3-kinase gamma, Rac, and PAK signaling in chemokine-induced macrophage migration

31 March 2020

1 reference

The phosphoinositide (PI) 3-kinase family

31 March 2020

1 reference

Synthesis and function of 3-phosphorylated inositol lipids

31 March 2020

1 reference

The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism

31 March 2020

1 reference

Proliferative defect and embryonic lethality in mice homozygous for a deletion in the p110alpha subunit of phosphoinositide 3-kinase

31 March 2020

1 reference

Critical role for the p110alpha phosphoinositide-3-OH kinase in growth and metabolic regulation

31 March 2020

1 reference

A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling

31 March 2020

1 reference

High frequency of mutations of the PIK3CA gene in human cancers

31 March 2020

1 reference

Oncogenic PI3K deregulates transcription and translation

31 March 2020

1 reference

PI 3-kinase p110beta: a new target for antithrombotic therapy

31 March 2020

1 reference

PI3K in lymphocyte development, differentiation and activation

31 March 2020

1 reference

A novel phosphoinositide 3 kinase activity in myeloid-derived cells is activated by G protein beta gamma subunits

31 March 2020

1 reference

Cloning and characterization of a G protein-activated human phosphoinositide-3 kinase

31 March 2020

1 reference

The G beta gamma sensitivity of a PI3K is dependent upon a tightly associated adaptor, p101

31 March 2020

1 reference

Characterizing the interactions between the two subunits of the p101/p110gamma phosphoinositide 3-kinase and their role in the activation of this enzyme by G beta gamma subunits

31 March 2020

1 reference

Crystal structure and functional analysis of Ras binding to its effector phosphoinositide 3-kinase gamma

31 March 2020

1 reference

Activation of phosphoinositide 3-kinase gamma by Ras.

31 March 2020

1 reference

Bifurcation of lipid and protein kinase signals of PI3Kgamma to the protein kinases PKB and MAPK

31 March 2020

1 reference

Phosphoinositide 3-kinase gamma is a mediator of Gbetagamma-dependent Jun kinase activation

31 March 2020

1 reference

Phosphoinositide 3-kinases as targets for therapeutic intervention

31 March 2020

1 reference

G-protein signaling: back to the future

31 March 2020

1 reference

31 March 2020

1 reference

Roles of PLC-beta2 and -beta3 and PI3Kgamma in chemoattractant-mediated signal transduction

31 March 2020

1 reference

Chemoattractant receptor-stimulated F-actin polymerization in the human neutrophil is signaled by 2 distinct pathways

31 March 2020

1 reference

Role of Rac in controlling the actin cytoskeleton and chemotaxis in motile cells

31 March 2020

1 reference

Ion-channel regulation by G proteins.

31 March 2020

1 reference

Central role for G protein-coupled phosphoinositide 3-kinase gamma in inflammation.

31 March 2020

1 reference

Function of PI3Kgamma in thymocyte development, T cell activation, and neutrophil migration

31 March 2020

1 reference

PI3Kγ Modulates the Cardiac Response to Chronic Pressure Overload by Distinct Kinase-Dependent and -Independent Effects

31 March 2020

1 reference

Weakening link to colorectal cancer?

31 March 2020

1 reference

Strategies for chemokine antagonists as therapeutics

31 March 2020

1 reference

Chemokine inhibition--why, when, where, which and how?

31 March 2020

1 reference

Chemokines, chemokine receptors and small-molecule antagonists: recent developments

31 March 2020

1 reference

The clinical potential of chemokine receptor antagonists

31 March 2020

1 reference

The toxicology of chemokine inhibition.

31 March 2020

1 reference

Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor: the role of phosphatidylinositol 3,4,5-trisphosphate in neutrophil responses.

31 March 2020

1 reference

Airway inflammation: chemokine-induced neutrophilia and the class I phosphoinositide 3-kinases

31 March 2020

1 reference

Sequential activation of class IB and class IA PI3K is important for the primed respiratory burst of human but not murine neutrophils

31 March 2020

1 reference

The role of endothelial PI3Kgamma activity in neutrophil trafficking

31 March 2020

1 reference

Requirement for PI 3-kinase gamma in macrophage migration to MCP-1 and CSF-1.

31 March 2020

1 reference

Defective dendritic cell migration and activation of adaptive immunity in PI3Kgamma-deficient mice

31 March 2020

1 reference

Phosphoinositide-3 kinases critically regulate the recruitment and survival of eosinophils in vivo: importance for the resolution of allergic inflammation

31 March 2020

1 reference

Cutting edge: differential roles for phosphoinositide 3-kinases, p110gamma and p110delta, in lymphocyte chemotaxis and homing

31 March 2020

1 reference

Do phosphoinositide 3-kinases direct lymphocyte navigation?

31 March 2020

1 reference

Activation of phosphoinositide 3-kinases by the CCR4 ligand macrophage-derived chemokine is a dispensable signal for T lymphocyte chemotaxis

31 March 2020

1 reference

Class IB-phosphatidylinositol 3-kinase (PI3K) deficiency ameliorates IA-PI3K-induced systemic lupus but not T cell invasion.

31 March 2020

1 reference

Differential requirements for DOCK2 and phosphoinositide-3-kinase gamma during T and B lymphocyte homing

31 March 2020

1 reference

Integrated signalling pathways for mast-cell activation

31 March 2020

1 reference

Phosphoinositide 3-kinase gamma is an essential amplifier of mast cell function

31 March 2020

1 reference

Resistance to thromboembolism in PI3Kgamma-deficient mice.

31 March 2020

1 reference

The relative role of PLCbeta and PI3Kgamma in platelet activation

31 March 2020

1 reference

Phosphoinositide 3-kinase: diverse roles in immune cell activation

31 March 2020

1 reference

Phosphatidylinositol 3-kinase regulates the CD4/CD8 T cell differentiation ratio

31 March 2020

1 reference

Gbetagamma dimers stimulate vascular L-type Ca2+ channels via phosphoinositide 3-kinase

31 March 2020

1 reference

Angiotensin II stimulation of Ca2+-channel current in vascular smooth muscle cells is inhibited by lavendustin-A and LY-294002.

31 March 2020

1 reference

Phosphoinositide 3-kinase gamma mediates angiotensin II-induced stimulation of L-type calcium channels in vascular myocytes

31 March 2020

1 reference

PI3King the L-type calcium channel activation mechanism

31 March 2020

1 reference

Protection from angiotensin II-mediated vasculotoxic and hypertensive response in mice lacking PI3Kgamma

31 March 2020

1 reference

Phosphoinositide 3-kinase-dependent activation of Rac.

31 March 2020

1 reference

Cardiac hypertrophy: role of G protein-coupled receptors

31 March 2020

1 reference

Regulation of myocardial contractility and cell size by distinct PI3K-PTEN signaling pathways

31 March 2020

1 reference

Phosphoinositide 3-kinase gamma-deficient mice are protected from isoproterenol-induced heart failure.

31 March 2020

1 reference

CC chemokine receptor 2 is critical for induction of experimental autoimmune encephalomyelitis

31 March 2020

1 reference

Essential role for the C5a receptor in regulating the effector phase of synovial infiltration and joint destruction in experimental arthritis

31 March 2020

1 reference

Chemokines and chemokine receptors in rheumatoid arthritis

31 March 2020

1 reference

Mast cells: a cellular link between autoantibodies and inflammatory arthritis

31 March 2020

1 reference

Blockade of PI3Kgamma suppresses joint inflammation and damage in mouse models of rheumatoid arthritis.

31 March 2020

1 reference

Ablation of phosphoinositide 3-kinase-gamma reduces the severity of acute pancreatitis

31 March 2020

1 reference

PI3Kgamma inhibition blocks glomerulonephritis and extends lifespan in a mouse model of systemic lupus

31 March 2020

1 reference

31 March 2020

1 reference

A crucial role for the p110delta subunit of phosphatidylinositol 3-kinase in B cell development and activation

31 March 2020

1 reference

Essential, nonredundant role for the phosphoinositide 3-kinase p110delta in signaling by the B-cell receptor complex.

31 March 2020

1 reference

Structural insights into phosphoinositide 3-kinase catalysis and signalling

31 March 2020

1 reference

Structural Determinants of Phosphoinositide 3-Kinase Inhibition by Wortmannin, LY294002, Quercetin, Myricetin, and Staurosporine

31 March 2020

1 reference

Chemistry and biology of wortmannin

31 March 2020

1 reference

Therapeutic potential of phosphoinositide 3-kinase inhibitors.

31 March 2020

1 reference

Wortmannin inactivates phosphoinositide 3-kinase by covalent modification of Lys-802, a residue involved in the phosphate transfer reaction

31 March 2020

1 reference

Essential role of phosphoinositide 3-kinase delta in neutrophil directional movement

31 March 2020

1 reference

Furan-2-ylmethylene thiazolidinediones as novel, potent, and selective inhibitors of phosphoinositide 3-kinase gamma

31 March 2020

1 reference

Isoform-specific phosphoinositide 3-kinase inhibitors from an arylmorpholine scaffold

31 March 2020

1 reference

N-(cycloalkylamino)acyl-2-aminothiazole inhibitors of cyclin-dependent kinase 2. N-[5-[[[5-(1,1-dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4- piperidinecarboxamide (BMS-387032), a highly efficacious and selective antitumor agent

31 March 2020

1 reference

Discovery and SAR of 2-aminothiazole inhibitors of cyclin-dependent kinase 5/p25 as a potential treatment for Alzheimer's disease

31 March 2020

1 reference

Discovery of aminothiazole inhibitors of cyclin-dependent kinase 2: synthesis, X-ray crystallographic analysis, and biological activities

31 March 2020

1 reference

Discovery and initial SAR of 2-amino-5-carboxamidothiazoles as inhibitors of the Src-family kinase p56Lck

31 March 2020

1 reference

Design and synthesis of phenethyl benzo[1,4]oxazine-3-ones as potent inhibitors of PI3Kinasegamma

31 March 2020

1 reference

Study on improving the selectivity of compounds that inhibit two PI3Ks (gamma and delta).

31 March 2020

1 reference

Action mechanisms and structure-activity relationships of PI3Kgamma inhibitors on the enzyme: a molecular modeling study.

31 March 2020

1 reference

Features of selective kinase inhibitors

31 March 2020

1 reference

Apoptosis as a therapeutic tool in rheumatoid arthritis

31 March 2020

1 reference

Essential role for the p110delta phosphoinositide 3-kinase in the allergic response

31 March 2020

1 reference

Involvement of phosphoinositide 3-kinases in neutrophil activation and the development of acute lung injury

31 March 2020

1 reference

Phosphoinositide 3-kinase gamma-deficient hearts are protected from the PAF-dependent depression of cardiac contractility.

31 March 2020

1 reference

Phosphoinositide 3-kinase gamma controls autonomic regulation of the mouse heart through Gi-independent downregulation of cAMP level.

31 March 2020

1 reference

Electrical signals control wound healing through phosphatidylinositol-3-OH kinase-gamma and PTEN.

31 March 2020

1 reference