COSMID: A Web-based Tool for Identifying and Validating CRISPR/Cas Off-target Sites (Q34745306)

4 August 2017

COSMID: A Web-based Tool for Identifying and Validating CRISPR/Cas Off-target Sites (English)

1 reference

4 August 2017

0 references

Eli J Fine

4

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Ciaran M Lee

object named as

Ciaran M Lee

3

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Thomas J. Cradick

object named as

Thomas J Cradick

1

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author name string

Peng Qiu

2

1 reference

PubMed ID

25462530

4 August 2017

Gang Bao

5

1 reference

4 August 2017

2 December 2014

1 reference

Molecular Therapy. Nucleic acids

4 August 2017

1 reference

4 August 2017

3

1 reference

4 August 2017

e214

1 reference

PubMed ID

25462530

describes a project that uses

4 August 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4272406/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

CHOPCHOP: a CRISPR/Cas9 and TALEN web tool for genome editing

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4272406

CRISPR/Cas9 systems have off-target activity with insertions or deletions between target DNA and guide RNA sequences

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4272406

Dimeric CRISPR RNA-guided FokI nucleases for highly specific genome editing

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4272406

Fusion of catalytically inactive Cas9 to FokI nuclease improves the specificity of genome modification

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4272406

Cas-OFFinder: a fast and versatile algorithm that searches for potential off-target sites of Cas9 RNA-guided endonucleases

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4272406

An online bioinformatics tool predicts zinc finger and TALE nuclease off-target cleavage

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4272406

Double nicking by RNA-guided CRISPR Cas9 for enhanced genome editing specificity

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4272406

Multiplexed activation of endogenous genes by CRISPR-on, an RNA-guided transcriptional activator system

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4272406

Efficient genome engineering in human pluripotent stem cells using Cas9 from Neisseria meningitidis

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4272406

CRISPR/Cas9 systems targeting β-globin and CCR5 genes have substantial off-target activity

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4272406

High-throughput profiling of off-target DNA cleavage reveals RNA-programmed Cas9 nuclease specificity

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4272406

DNA targeting specificity of RNA-guided Cas9 nucleases

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4272406

High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4272406

Chromosomal deletions and inversions mediated by TALENs and CRISPR/Cas in zebrafish.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4272406

ZFN, TALEN, and CRISPR/Cas-based methods for genome engineering

7 July 2018

1 reference

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Protospacer recognition motifs: mixed identities and functional diversity

7 July 2018

1 reference

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RNA-programmed genome editing in human cells

7 July 2018

1 reference

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RNA-guided editing of bacterial genomes using CRISPR-Cas systems

7 July 2018

1 reference

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RNA-guided human genome engineering via Cas9

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4272406

Multiplex genome engineering using CRISPR/Cas systems

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4272406

Cas9-crRNA ribonucleoprotein complex mediates specific DNA cleavage for adaptive immunity in bacteria

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4272406

An archaeal immune system can detect multiple protospacer adjacent motifs (PAMs) to target invader DNA.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4272406

A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4272406

FLASH assembly of TALENs for high-throughput genome editing

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4272406

Engineered zinc finger nickases induce homology-directed repair with reduced mutagenic effects

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4272406

A novel TALE nuclease scaffold enables high genome editing activity in combination with low toxicity.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4272406

Genetic engineering of human pluripotent cells using TALE nucleases

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4272406

ZFN-site searches genomes for zinc finger nuclease target sites and off-target sites.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4272406

The CRISPR/Cas bacterial immune system cleaves bacteriophage and plasmid DNA

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4272406

A rapid and general assay for monitoring endogenous gene modification

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4272406

Quantification of zinc finger nuclease-associated toxicity

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4272406

ZiFiT (Zinc Finger Targeter): an updated zinc finger engineering tool

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4272406

CRISPR interference: RNA-directed adaptive immunity in bacteria and archaea

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4272406

CRISPR/Cas, the immune system of bacteria and archaea

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4272406

RNA-guided RNA cleavage by a CRISPR RNA-Cas protein complex

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4272406

CRISPI: a CRISPR interactive database

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4272406

Short motif sequences determine the targets of the prokaryotic CRISPR defence system

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4272406

Small CRISPR RNAs guide antiviral defense in prokaryotes

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4272406

Diversity, activity, and evolution of CRISPR loci in Streptococcus thermophilus

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4272406

Indexing strategies for rapid searches of short words in genome sequences.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4272406

CRISPR Recognition Tool (CRT): a tool for automatic detection of clustered regularly interspaced palindromic repeats

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4272406

CRISPRFinder: a web tool to identify clustered regularly interspaced short palindromic repeats

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4272406

The CRISPRdb database and tools to display CRISPRs and to generate dictionaries of spacers and repeats

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4272406

CRISPR Provides Acquired Resistance Against Viruses in Prokaryotes

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4272406

Clustered regularly interspaced short palindrome repeats (CRISPRs) have spacers of extrachromosomal origin

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4272406

Accelerating genome editing in CHO cells using CRISPR Cas9 and CRISPy, a web-based target finding tool

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4272406

CasOT: a genome-wide Cas9/gRNA off-target searching tool

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4272406

Knockout rats generated by embryo microinjection of TALENs.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4272406

26 October 2018

Identifiers

DOI

10.1038/MTNA.2014.64

1 reference

4 August 2017

1 reference

4 August 2017

1 reference

PubMed ID

25462530