Molecular characterization of the NPC1L1 variants identified from cholesterol low absorbers (Q34606333)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21189420%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

title

Molecular characterization of the NPC1L1 variants identified from cholesterol low absorbers (English)

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18 January 2020

6

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18 January 2020

author name string

Li-Juan Wang

1

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18 January 2020

Jing Wang

2

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18 January 2020

Na Li

3

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18 January 2020

Liang Ge

4

1 reference

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18 January 2020

Bo-Liang Li

5

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18 January 2020

language of work or name

English

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publication date

28 December 2010

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21189420%20AND%20SRC:MED&resulttype=core&format=json

Journal of Biological Chemistry

18 January 2020

number of pages

12

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based on heuristic

inferred from page(s)

published in

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18 January 2020

volume

286

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18 January 2020

issue

9

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18 January 2020

page(s)

7397-7408

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Genetic variation at the NPC1L1 gene locus, plasma lipoproteins, and heart disease risk in the elderly

18 January 2020

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An NPC1L1 gene promoter variant is associated with autosomal dominant hypercholesterolemia

7 July 2018

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Identification of a physiologically relevant endogenous ligand for PPARalpha in liver

7 July 2018

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Requirement of myosin Vb.Rab11a.Rab11-FIP2 complex in cholesterol-regulated translocation of NPC1L1 to the cell surface

7 July 2018

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Membrane topology of human NPC1L1, a key protein in enterohepatic cholesterol absorption

7 July 2018

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N-glycans are direct determinants of CFTR folding and stability in secretory and endocytic membrane traffic

7 July 2018

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Niemann-Pick C1 Like 1 (NPC1L1) an intestinal sterol transporter

7 July 2018

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The g.-762T>C polymorphism of the NPC1L1 gene is common in Chinese and contributes to a higher promoter activity and higher serum cholesterol levels.

7 July 2018

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7 July 2018

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Extracellular loop C of NPC1L1 is important for binding to ezetimibe

7 July 2018

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The cholesterol absorption inhibitor ezetimibe acts by blocking the sterol-induced internalization of NPC1L1.

7 July 2018

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Functional characterization of genetic variants in NPC1L1 supports the sequencing extremes strategy to identify complex trait genes

7 July 2018

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Ufd1 is a cofactor of gp78 and plays a key role in cholesterol metabolism by regulating the stability of HMG-CoA reductase

7 July 2018

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Zetia: inhibition of Niemann-Pick C1 Like 1 (NPC1L1) to reduce intestinal cholesterol absorption and treat hyperlipidemia

7 July 2018

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7 July 2018

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Effect of ezetimibe coadministered with statins in genotype-confirmed heterozygous FH patients

7 July 2018

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Multiple rare variants in NPC1L1 associated with reduced sterol absorption and plasma low-density lipoprotein levels

7 July 2018

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NPC1L1 haplotype is associated with inter-individual variation in plasma low-density lipoprotein response to ezetimibe

7 July 2018

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The target of ezetimibe is Niemann-Pick C1-Like 1 (NPC1L1)

7 July 2018

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Inactivation of NPC1L1 causes multiple lipid transport defects and protects against diet-induced hypercholesterolemia.

7 July 2018

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Niemann-Pick C1 Like 1 protein is critical for intestinal cholesterol absorption

7 July 2018

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Direct binding of ubiquitin conjugates by the mammalian p97 adaptor complexes, p47 and Ufd1-Npl4.

7 July 2018

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ER-associated degradation in protein quality control and cellular regulation

7 July 2018

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Cholesterol addition to ER membranes alters conformation of SCAP, the SREBP escort protein that regulates cholesterol metabolism

7 July 2018

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A tubular EHD1-containing compartment involved in the recycling of major histocompatibility complex class I molecules to the plasma membrane

7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Genetic variation in ABC G5/G8 and NPC1L1 impact cholesterol response to plant sterols in hypercholesterolemic men.

21 January 2018

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Compound heterozygosity for two non-synonymous polymorphisms in NPC1L1 in a non-responder to ezetimibe

21 January 2018

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Percent cholesterol absorption in normal women and men quantified with dual stable isotopic tracers and negative ion mass spectrometry.

21 January 2018

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19 Receptor-mediated endocytosis of low-density lipoprotein in cultured cells

26 October 2018

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PubMed

https://pubmed.ncbi.nlm.nih.gov/21189420

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12 December 2020

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Purification of the oligosaccharide-cleaving enzymes of Flavobacterium meningosepticum

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PubMed

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12 December 2020

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Identifiers

DOI

10.1074/JBC.M110.178368

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21189420%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

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18 January 2020

1 reference