Telomeres, aging and cancer: in search of a happy ending (Q34535605)

2 August 2017

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title

Telomeres, aging and cancer: in search of a happy ending (English)

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2 August 2017

Sahn-ho Kim Sh

1

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2 August 2017

Patrick Kaminker

series ordinal

2

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2 August 2017

Judith Campisi

series ordinal

3

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2 August 2017

language of work or name

English

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publication date

1 January 2002

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2 August 2017

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2 August 2017

21

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2 August 2017

503-511

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2 August 2017

4

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1205077

2 August 2017

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cites work

Telomere shortening is associated with cell division in vitro and in vivo

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205077

Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205077

DNA double-strand break repair proteins are required to cap the ends of mammalian chromosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205077

Strand-Specific Postreplicative Processing of Mammalian Telomeres

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205077

Pot1, the putative telomere end-binding protein in fission yeast and humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205077

Telomere states and cell fates

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205077

Telomere shortening and tumor formation by mouse cells lacking telomerase RNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205077

Extension of life-span by introduction of telomerase into normal human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205077

Human telomeres contain two distinct Myb-related proteins, TRF1 and TRF2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205077

Telomerase regulation during entry into the cell cycle in normal human T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205077

Genetic instability and darwinian selection in tumours

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205077

From cells to organisms: can we learn about aging from cells in culture?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205077

N-nitroso-N-methylurea-induced rat mammary tumors arise from cells with preexisting oncogenic Hras1 gene mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205077

Telomere length and replicative aging in human vascular tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205077

Molecular analysis of H2O2-induced senescent-like growth arrest in normal human fibroblasts: p53 and Rb control G1 arrest but not cell replication

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205077

Tankyrase is a golgi-associated mitogen-activated protein kinase substrate that interacts with IRAP in GLUT4 vesicles

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205077

p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205077

Replicative senescence and cell immortality: the role of telomeres and telomerase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205077

A human telomeric protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205077

Telomere length regulation during postnatal development and ageing in Mus spretus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205077

Loss of heterozygosity in normal tissue adjacent to breast carcinomas.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205077

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205077

A biomarker that identifies senescent human cells in culture and in aging skin in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205077

Rapid accumulation of genome rearrangements in liver but not in brain of old mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205077

Distinct spectra of somatic mutations accumulated with age in mouse heart and small intestine

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205077

Turning telomeres off and on.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205077

Telomere maintenance by recombination in human cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205077

Replicative senescence in the immune system: impact of the Hayflick limit on T-cell function in the elderly

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205077

Telomerase expression restores dermal integrity to in vitro-aged fibroblasts in a reconstituted skin model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205077

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205077

Telomerase-deficient mice with short telomeres are resistant to skin tumorigenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205077

Increased epidermal tumors and increased skin wound healing in transgenic mice overexpressing the catalytic subunit of telomerase, mTERT, in basal keratinocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205077

Genome changes and gene expression in human solid tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205077

Short dysfunctional telomeres impair tumorigenesis in the INK4a(delta2/3) cancer-prone mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205077

Telomere length regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205077

Mammalian telomeres end in a large duplex loop

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205077

Inhibition of telomerase limits the growth of human cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205077

Creation of human tumour cells with defined genetic elements

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205077

Telomerase activity in the regenerative basal layer of the epidermis inhuman skin and in immortal and carcinoma-derived skin keratinocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205077

Wild-derived inbred mouse strains have short telomeres

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205077

Disease states associated with telomerase deficiency appear earlier in mice with short telomeres

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205077

Impaired germinal center reaction in mice with short telomeres.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205077

Multiple pathways for the regulation of telomerase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205077

Ku is associated with the telomere in mammals

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205077

Ku acts in a unique way at the mammalian telomere to prevent end joining

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205077

Telomerase expression in human somatic cells does not induce changes associated with a transformed phenotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205077

Frequent clones of p53-mutated keratinocytes in normal human skin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205077

Human is a unique species among primates in terms of telomere length.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205077

TANK2, a new TRF1-associated poly(ADP-ribose) polymerase, causes rapid induction of cell death upon overexpression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205077

p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205077

Specific association of human telomerase activity with immortal cells and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205077

TIN2, a new regulator of telomere length in human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205077

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205077

Telomere biology in human aging and aging syndromes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205077

Molecular interaction map of the mammalian cell cycle control and DNA repair systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205077

Senescent fibroblasts promote epithelial cell growth and tumorigenesis: a link between cancer and aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205077

Essential role of mouse telomerase in highly proliferative organs

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205077

Telomere end-replication problem and cell aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205077

Identification of human Rap1: implications for telomere evolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205077

Telomerase and chromosome end maintenance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205077

Genes involved in senescence and immortalization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205077

Long G tails at both ends of human chromosomes suggest a C strand degradation mechanism for telomere shortening

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205077

Telomeres and their control

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205077

Gerontology as oncology. Research on aging as the key to the understanding of cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205077

A telomerase component is defective in the human disease dyskeratosis congenita

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205077

Absence of cancer-associated changes in human fibroblasts immortalized with telomerase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205077

t-loops at trypanosome telomeres.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205077

Subsenescent telomere lengths in fibroblasts immortalized by limiting amounts of telomerase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205077

The influence of the microenvironment on the malignant phenotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205077

Developmental and tissue-specific regulation of mouse telomerase and telomere length

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205077

Longevity, Stress Response, and Cancer in Aging Telomerase-Deficient Mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205077

Mammalian Ku86 protein prevents telomeric fusions independently of the length of TTAGGG repeats and the G-strand overhang

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205077

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205077

Cellular senescence: mitotic clock or culture shock?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205077

Telomerase and telomere-binding proteins: controlling the endgame.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205077

Tankyrase, a poly(ADP-ribose) polymerase at human telomeres

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205077

The DNA-dependent protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205077

Interaction of human Ku70 with TRF2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205077

Analysis of genomic integrity and p53-dependent G1 checkpoint in telomerase-induced extended-life-span human fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205077

TRF2 Protects Human Telomeres from End-to-End Fusions

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205077

The DNA structures at the ends of eukaryotic chromosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205077

Regulated expression of telomerase activity in human T lymphocyte development and activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205077

Telomere dynamics in cancer progression and prevention: fundamental differences in human and mouse telomere biology

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205077

NBS1 and TRF1 colocalize at promyelocytic leukemia bodies during late S/G2 phases in immortalized telomerase-negative cells. Implication of NBS1 in alternative lengthening of telomeres

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205077

Human endothelial cell life extension by telomerase expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205077

Telomere shortening and apoptosis in telomerase-inhibited human tumor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205077

Telomere length regulation in mice is linked to a novel chromosome locus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205077

Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205077

Replicative senescence in normal liver, chronic hepatitis C, and hepatocellular carcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205077

Evidence for an alternative mechanism for maintaining telomere length in human tumors and tumor-derived cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205077

7 January 2021

Functions of poly(ADP-ribose) polymerase in controlling telomere length and chromosomal stability.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205077

7 January 2021

Cellular proliferation potential during aging and caloric restriction in rhesus monkeys (Macaca mulatta)

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205077

7 January 2021

A role for both RB and p53 in the regulation of human cellular senescence

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205077

7 January 2021

Reconstitution of telomerase activity in normal human cells leads to elongation of telomeres and extended replicative life span

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205077

7 January 2021

Telomere shortening and decline in replicative potential as a function of donor age in human adrenocortical cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205077

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1205077

1 reference

Dimensions Publication ID

2 August 2017

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1 reference