HERV-K(HML-2), a seemingly silent subtenant - but still waters run deep (Q34511101)

2 August 2017

HERV-K(HML-2), a seemingly silent subtenant - but still waters run deep (English)

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2 August 2017

Kirsten Hanke

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PubMed ID

26818263

2 August 2017

Oliver Hohn

series ordinal

2

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PubMed ID

26818263

2 August 2017

Norbert Bannert

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3

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2 August 2017

1 January 2016

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Acta Pathologica et Microbiologica Scandinavica

2 August 2017

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2 August 2017

124

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2 August 2017

1-2

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2 August 2017

67-87

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Chromosomal distribution of endogenous Jaagsiekte sheep retrovirus proviral sequences in the sheep genome

2 August 2017

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Endogenous mouse mammary tumor viruses (mtv): new roles for an old virus in cancer, infection, and immunity

21 January 2018

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Syncytin is a captive retroviral envelope protein involved in human placental morphogenesis

21 January 2018

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Identification, characterization, and comparative genomic distribution of the HERV-K (HML-2) group of human endogenous retroviruses

21 January 2018

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Human endogenous retrovirus family HERV-K(HML-5): status, evolution, and reconstruction of an ancient betaretrovirus in the human genome

21 January 2018

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Allelic variation of HERV-K(HML-2) endogenous retroviral elements in human populations.

21 January 2018

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Human endogenous retrovirus K solo-LTR formation and insertional polymorphisms: implications for human and viral evolution

21 January 2018

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HIV infection reveals widespread expansion of novel centromeric human endogenous retroviruses

21 January 2018

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Expansion of a novel endogenous retrovirus throughout the pericentromeres of modern humans

21 January 2018

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Unfixed endogenous retroviral insertions in the human population

21 January 2018

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A high-coverage genome sequence from an archaic Denisovan individual

21 January 2018

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The complete genome sequence of a Neanderthal from the Altai Mountains

21 January 2018

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Genetic history of an archaic hominin group from Denisova Cave in Siberia

21 January 2018

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Novel Denisovan and Neanderthal retroviruses

21 January 2018

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Insertional polymorphisms of endogenous HERV-K113 and HERV-K115 retroviruses in breast cancer patients and age-matched controls

21 January 2018

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The distribution of the endogenous retroviruses HERV-K113 and HERV-K115 in health and disease

21 January 2018

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Molecular cloning and functional characterization of the human endogenous retrovirus K113.

21 January 2018

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Reconstitution of the ancestral glycoprotein of human endogenous retrovirus k and modulation of its functional activity by truncation of the cytoplasmic domain

21 January 2018

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Identification of the protease cleavage sites in a reconstituted Gag polyprotein of an HERV-K(HML-2) element

21 January 2018

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The Rec protein of HERV-K(HML-2) upregulates androgen receptor activity by binding to the human small glutamine-rich tetratricopeptide repeat protein (hSGT).

21 January 2018

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Recombinant origin of the retrovirus XMRV.

21 January 2018

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Nucleic acid-sensing Toll-like receptors are essential for the control of endogenous retrovirus viremia and ERV-induced tumors

21 January 2018

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Endogenous retroviruses: acquisition, amplification and taming of genome invaders

21 January 2018

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Retroelements and the human genome: new perspectives on an old relation

21 January 2018

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Dynamic control of endogenous retroviruses during development.

21 January 2018

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Identification and characterization of a family of mammalian methyl-CpG binding proteins

21 January 2018

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CpG methylation directly regulates transcriptional activity of the human endogenous retrovirus family HERV-K(HML-2)

21 January 2018

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Human Teratocarcinomas Cultured in vitro Produce Unique Retrovirus-like Viruses

21 January 2018

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Regulation of human endogenous retrovirus-K expression in melanomas by CpG methylation

21 January 2018

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Perspective: transposable elements, parasitic DNA, and genome evolution

21 January 2018

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A large number of the human microRNAs target lentiviruses, retroviruses, and endogenous retroviruses.

21 January 2018

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G9a co-suppresses LINE1 elements in spermatogonia.

21 January 2018

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A piRNA pathway primed by individual transposons is linked to de novo DNA methylation in mice

21 January 2018

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MIWI2 is essential for spermatogenesis and repression of transposons in the mouse male germline

21 January 2018

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DNA methylation of retrotransposon genes is regulated by Piwi family members MILI and MIWI2 in murine fetal testes

21 January 2018

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The restriction factors of human immunodeficiency virus

21 January 2018

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Host restriction factors in retroviral infection: promises in virus-host interaction

21 January 2018

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Retrovirus restriction factors

21 January 2018

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Retroviral superinfection resistance

21 January 2018

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Expression of the jaagsiekte sheep retrovirus envelope glycoprotein is sufficient to induce lung tumors in sheep

21 January 2018

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Endogenous retroviruses in trophoblast differentiation and placental development

21 January 2018

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"Ménage à Trois": the evolutionary interplay between JSRV, enJSRVs and domestic sheep

21 January 2018

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Capsid-binding retrovirus restriction factors: discovery, restriction specificity and implications for the development of novel therapeutics

21 January 2018

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The cytoplasmic body component TRIM5alpha restricts HIV-1 infection in Old World monkeys

21 January 2018

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Modulation of TRIM5alpha activity in human cells by alternatively spliced TRIM5 isoforms

21 January 2018

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A Trim5-cyclophilin A fusion protein found in owl monkey kidney cells can restrict HIV-1.

21 January 2018

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Cyclophilin A retrotransposition into TRIM5 explains owl monkey resistance to HIV-1

21 January 2018

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Chance favors a prepared genome

21 January 2018

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Hexagonal assembly of a restricting TRIM5alpha protein

21 January 2018

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Reconstitution of an infectious human endogenous retrovirus

21 January 2018

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Isolation of a human gene that inhibits HIV-1 infection and is suppressed by the viral Vif protein

21 January 2018

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DNA deamination mediates innate immunity to retroviral infection

21 January 2018

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Hypermutation of HIV-1 DNA in the Absence of the Vif Protein

21 January 2018

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Broad antiretroviral defence by human APOBEC3G through lethal editing of nascent reverse transcripts

21 January 2018

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The cytidine deaminase CEM15 induces hypermutation in newly synthesized HIV-1 DNA

21 January 2018

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APOBEC-mediated editing of viral RNA.

21 January 2018

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APOBEC3G is incorporated into virus-like particles by a direct interaction with HIV-1 Gag nucleocapsid protein

21 January 2018

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Suppression of APOBEC3-mediated restriction of HIV-1 by Vif

21 January 2018

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Retroelements versus APOBEC3 family members: No great escape from the magnificent seven

21 January 2018

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APOBEC3G oligomerization is associated with the inhibition of both Alu and LINE-1 retrotransposition

21 January 2018

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Suppression of HIV-1 infection by APOBEC3 proteins in primary human CD4(+) T cells is associated with inhibition of processive reverse transcription as well as excessive cytidine deamination

21 January 2018

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APOBEC-mediated viral restriction: not simply editing?

21 January 2018

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APOBEC3G cytidine deaminase inhibits retrotransposition of endogenous retroviruses.

21 January 2018

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Footprint of APOBEC3 on the genome of human retroelements

21 January 2018

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Large-scale DNA editing of retrotransposons accelerates mammalian genome evolution.

21 January 2018

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Hypermutation of an ancient human retrovirus by APOBEC3G

21 January 2018

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P bodies: at the crossroads of post-transcriptional pathways

21 January 2018

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Proteomic and biochemical analysis of purified human immunodeficiency virus type 1 produced from infected monocyte-derived macrophages

21 January 2018

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Endogenous MOV10 inhibits the retrotransposition of endogenous retroelements but not the replication of exogenous retroviruses

21 January 2018

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P body-associated protein Mov10 inhibits HIV-1 replication at multiple stages

21 January 2018

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Perturbation of the P-body component Mov10 inhibits HIV-1 infectivity

21 January 2018

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MicroRNA silencing through RISC recruitment of eIF6

21 January 2018

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Identification of novel argonaute-associated proteins

21 January 2018

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Antiviral protein APOBEC3G localizes to ribonucleoprotein complexes found in P bodies and stress granules

21 January 2018

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The anti-HIV-1 editing enzyme APOBEC3G binds HIV-1 RNA and messenger RNAs that shuttle between polysomes and stress granules

21 January 2018

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Mov10 and APOBEC3G localization to processing bodies is not required for virion incorporation and antiviral activity.

21 January 2018

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Limelight on two HIV/SIV accessory proteins in macrophage infection: is Vpx overshadowing Vpr?

21 January 2018

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Host hindrance to HIV-1 replication in monocytes and macrophages

21 January 2018

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SIVSM/HIV-2 Vpx proteins promote retroviral escape from a proteasome-dependent restriction pathway present in human dendritic cells

21 January 2018

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SAMHD1-deficient CD14+ cells from individuals with Aicardi-Goutières syndrome are highly susceptible to HIV-1 infection

21 January 2018

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Vpx relieves inhibition of HIV-1 infection of macrophages mediated by the SAMHD1 protein

21 January 2018

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SAMHD1 is the dendritic- and myeloid-cell-specific HIV-1 restriction factor counteracted by Vpx

21 January 2018

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SAMHD1 restricts the replication of human immunodeficiency virus type 1 by depleting the intracellular pool of deoxynucleoside triphosphates

21 January 2018

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Restriction of diverse retroviruses by SAMHD1.

21 January 2018

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Mouse SAMHD1 has antiretroviral activity and suppresses a spontaneous cell-intrinsic antiviral response

21 January 2018

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SAMHD1-dependent retroviral control and escape in mice.

21 January 2018

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Genomic flexibility of human endogenous retrovirus type K

21 January 2018

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Tetherin inhibits retrovirus release and is antagonized by HIV-1 Vpu

21 January 2018

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The interferon-induced protein BST-2 restricts HIV-1 release and is downregulated from the cell surface by the viral Vpu protein

21 January 2018

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HIV-1 Vpu promotes release and prevents endocytosis of nascent retrovirus particles from the plasma membrane

21 January 2018

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An interferon-alpha-induced tethering mechanism inhibits HIV-1 and Ebola virus particle release but is counteracted by the HIV-1 Vpu protein

21 January 2018

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Bst-2/HM1.24 is a raft-associated apical membrane protein with an unusual topology

21 January 2018

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Immunoelectron microscopic evidence for Tetherin/BST2 as the physical bridge between HIV-1 virions and the plasma membrane

21 January 2018

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Tetherin inhibits HIV-1 release by directly tethering virions to cells

21 January 2018

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Structural basis of HIV-1 tethering to membranes by the BST-2/tetherin ectodomain

21 January 2018

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Mechanism of HIV-1 virion entrapment by tetherin

21 January 2018

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BCA2/Rabring7 promotes tetherin-dependent HIV-1 restriction

21 January 2018

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Counteraction of the multifunctional restriction factor tetherin

21 January 2018

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The HERV-K human endogenous retrovirus envelope protein antagonizes Tetherin antiviral activity

21 January 2018

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Endogenous retroviruses and cancer

21 January 2018

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HERV-K(HML-2) rec and np9 transcripts not restricted to disease but present in many normal human tissues.

21 January 2018

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Transcriptional profiling of human endogenous retrovirus group HERV-K(HML-2) loci in melanoma

21 January 2018

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Human endogenous retrovirus K (HML-2) RNA and protein expression is a marker for human embryonic and induced pluripotent stem cells.

21 January 2018

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Intrinsic retroviral reactivation in human preimplantation embryos and pluripotent cells

21 January 2018

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Selective changes of retroelement expression in human prostate cancer

21 January 2018

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HERV-K hypomethylation in ovarian clear cell carcinoma is associated with a poor prognosis and platinum resistance.

21 January 2018

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Distinctive patterns of age-dependent hypomethylation in interspersed repetitive sequences

21 January 2018

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Elevated HERV-K mRNA expression in PBMC is associated with a prostate cancer diagnosis particularly in older men and smokers

21 January 2018

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Endogenous retrovirus-K promoter: a landing strip for inflammatory transcription factors?

21 January 2018

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Expression of the human endogenous retrovirus (HERV) group HML-2/HERV-K does not depend on canonical promoter elements but is regulated by transcription factors Sp1 and Sp3.

21 January 2018

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A tale of three fingers: the family of mammalian Sp/XKLF transcription factors

21 January 2018

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Differential expression of HERV-K (HML-2) proviruses in cells and virions of the teratocarcinoma cell line Tera-1.

21 January 2018

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Identification of active loci of a human endogenous retrovirus in neurons of patients with amyotrophic lateral sclerosis

21 January 2018

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A role for human endogenous retrovirus-K (HML-2) in rheumatoid arthritis: investigating mechanisms of pathogenesis

21 January 2018

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Structural organization of unique retrovirus-like particles budding from human teratocarcinoma cell lines

21 January 2018

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Oncogenes in retroviruses and cells

21 January 2018

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Genome analysis and reverse transcriptase activity of human teratocarcinoma-derived retroviruses

21 January 2018

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Human endogenous retrovirus (HERV-K) reverse transcriptase as a breast cancer prognostic marker

21 January 2018

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Quantitation of HERV-K env gene expression and splicing in human breast cancer

21 January 2018

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The distribution of insertionally polymorphic endogenous retroviruses in breast cancer patients and cancer-free controls.

21 January 2018

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Expression of multiple human endogenous retrovirus surface envelope proteins in ovarian cancer.

21 January 2018

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Human endogenous retroviruses and cancer prevention: evidence and prospects

21 January 2018

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L1 and HERV-W retrotransposons are hypomethylated in human ovarian carcinomas

21 January 2018

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DNA methylation and expression of LINE-1 and HERV-K provirus sequences in urothelial and renal cell carcinomas

21 January 2018

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Evidence that HERV-K is the endogenous retrovirus sequence that codes for the human teratocarcinoma-derived retrovirus HTDV.

21 January 2018

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HERV-K(HML-2) GAG/ENV antibodies as indicator for therapy effect in patients with germ cell tumors.

21 January 2018

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Rec (formerly Corf) function requires interaction with a complex, folded RNA structure within its responsive element rather than binding to a discrete specific binding site

21 January 2018

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Expression of human endogenous retrovirus K in melanomas and melanoma cell lines

21 January 2018

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Biochemical Approach to Bovine Leukemia

21 January 2018

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Smoking increases transcription of human endogenous retroviruses in a newly established in vitro cell model and in normal urothelium.

21 January 2018

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Control of androgen receptor signaling in prostate cancer by the cochaperone small glutamine rich tetratricopeptide repeat containing protein alpha

21 January 2018

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Identification and gene structure of a novel human PLZF-related transcription factor gene, TZFP

21 January 2018

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Amplitude modulation of androgen signaling by c-MYC.

21 January 2018

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Human endogenous retrovirus protein cORF supports cell transformation and associates with the promyelocytic leukemia zinc finger protein

21 January 2018

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Physical and functional interactions of human endogenous retrovirus proteins Np9 and rec with the promyelocytic leukemia zinc finger protein

21 January 2018

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Human endogenous retrovirus rec interferes with germ cell development in mice and may cause carcinoma in situ, the predecessor lesion of germ cell tumors

21 January 2018

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Staufen-1 interacts with the human endogenous retrovirus family HERV-K(HML-2) rec and gag proteins and increases virion production

21 January 2018

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Expression and intracytoplasmic distribution of staufen and calreticulin in maturing human oocytes.

21 January 2018

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Multimerization of Staufen1 in live cells

21 January 2018

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Characterization of Staufen 1 ribonucleoprotein complexes

21 January 2018

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hiCLIP reveals the in vivo atlas of mRNA secondary structures recognized by Staufen 1.

21 January 2018

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The host protein Staufen1 interacts with the Pr55Gag zinc fingers and regulates HIV-1 assembly via its N-terminus

21 January 2018

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Regulation of the human endogenous retrovirus K (HML-2) transcriptome by the HIV-1 Tat protein

21 January 2018

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Expression of human endogenous retrovirus type K (HML-2) is activated by the Tat protein of HIV-1.

21 January 2018

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An ancient family of human endogenous retroviruses encodes a functional homolog of the HIV-1 Rev protein

21 January 2018

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Human endogenous retrovirus K Gag coassembles with HIV-1 Gag and reduces the release efficiency and infectivity of HIV-1.

21 January 2018

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HIV-1 interacts with human endogenous retrovirus K (HML-2) envelopes derived from human primary lymphocytes

21 January 2018

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Functional characterization of the protease of human endogenous retrovirus, K10: can it complement HIV-1 protease?

21 January 2018

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Analysis of human immunodeficiency virus type 1 containing HERV-K protease

21 January 2018

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HERV-K(HML-2), the Best Preserved Family of HERVs: Endogenization, Expression, and Implications in Health and Disease

21 January 2018

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HIV infection and HERV expression: a review

21 January 2018

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Comparative longitudinal studies of HERV-K and HIV-1 RNA titers in HIV-1-infected patients receiving successful versus unsuccessful highly active antiretroviral therapy

21 January 2018

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A new Real-Time-RT-PCR for quantitation of human endogenous retroviruses type K (HERV-K) RNA load in plasma samples: increased HERV-K RNA titers in HIV-1 patients with HAART non-suppressive regimens.

21 January 2018

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Detection of HERV-K(HML-2) viral RNA in plasma of HIV type 1-infected individuals

21 January 2018

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HIV-1 infection increases the expression of human endogenous retroviruses type K (HERV-K) in vitro

21 January 2018

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Characterization of human endogenous retroviral elements in the blood of HIV-1-infected individuals

21 January 2018

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Human endogenous retrovirus K (HML-2) elements in the plasma of people with lymphoma and breast cancer

21 January 2018

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Human endogenous retrovirus expression is inversely associated with chronic immune activation in HIV-1 infection

21 January 2018

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Analysis of HIV-1 expression level and sense of transcription by high-throughput sequencing of the infected cell

21 January 2018

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HIV-1 infection leads to increased transcription of human endogenous retrovirus HERV-K (HML-2) proviruses in vivo but not to increased virion production

21 January 2018

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Modulation of human endogenous retrovirus (HERV) transcription during persistent and de novo HIV-1 infection

21 January 2018

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The viruses in all of us: characteristics and biological significance of human endogenous retrovirus sequences

21 January 2018

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Trans-activation, post-transcriptional maturation, and induction of antibodies to HERV-K (HML-2) envelope transmembrane protein in HIV-1 infection

21 January 2018

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Cutting edge: An antibody recognizing ancestral endogenous virus glycoproteins mediates antibody-dependent cellular cytotoxicity on HIV-1-infected cells

21 January 2018

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T cell responses to human endogenous retroviruses in HIV-1 infection

21 January 2018

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Strong human endogenous retrovirus-specific T cell responses are associated with control of HIV-1 in chronic infection

21 January 2018

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Identification of human endogenous retrovirus-specific T cell responses in vertically HIV-1-infected subjects.

21 January 2018

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HERV-K-specific T cells eliminate diverse HIV-1/2 and SIV primary isolates.

21 January 2018

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Human endogenous retrovirus K(HML-2) Gag- and Env-specific T-cell responses are infrequently detected in HIV-1-infected subjects using standard peptide matrix-based screening.

21 January 2018

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An Epstein-Barr virus-associated superantigen

21 January 2018

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Epstein-Barr virus transactivates the human endogenous retrovirus HERV-K18 that encodes a superantigen

21 January 2018

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HHV-6A infection induces expression of HERV-K18-encoded superantigen

21 January 2018

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Human herpesvirus-6B induces expression of the human endogenous retrovirus K18-encoded superantigen

21 January 2018

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Identification of an infectious progenitor for the multiple-copy HERV-K human endogenous retroelements

21 January 2018

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Identification of late assembly domains of the human endogenous retrovirus-K(HML-2).

21 January 2018

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Cloning and characterization of a cell surface receptor for xenotropic and polytropic murine leukemia viruses

21 January 2018

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Integration target site selection by a resurrected human endogenous retrovirus

21 January 2018

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The HTLV-1 Virological Synapse.

21 January 2018

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CMV-promoter driven codon-optimized expression alters the assembly type and morphology of a reconstituted HERV-K(HML-2)

21 January 2018

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Multiple effects govern endogenous retrovirus survival patterns in human gene introns

21 January 2018

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Human Endogenous Retrovirus Type K (HERV-K) Particles Package and Transmit HERV-K-Related Sequences

21 January 2018

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Characterization of the human endogenous retrovirus K Gag protein: identification of protease cleavage sites.

21 January 2018

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Comparative primate genomics

21 January 2018

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Constructing primate phylogenies from ancient retrovirus sequences

21 January 2018

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Identification of a novel family of human endogenous retroviruses and characterization of one family member, HERV-K(C4), located in the complement C4 gene cluster.

21 January 2018

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Characterization of Human MMTV-like (HML) Elements Similar to a Sequence That Was Highly Expressed in a Human Breast Cancer: Further Definition of the HML-6 Group

21 January 2018

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The replicative activity of human endogenous retrovirus K102 (HERV-K102) with HIV viremia

21 January 2018

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21 January 2018

Identifiers

DOI

10.1111/APM.12475

1 reference

2 August 2017

1 reference

PubMed ID

26818263