Hominoid-specific enzyme GLUD2 promotes growth of IDH1R132H glioma (Q34314291)

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16 February 2020

title

Hominoid-specific enzyme GLUD2 promotes growth of IDH1R132H glioma (English)

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16 February 2020

1

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Anneleen Daemen

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16 February 2020

author name string

Merry C Nishimura

2

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16 February 2020

Samir Kharbanda

3

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16 February 2020

Frank Peale

4

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16 February 2020

Yuzhong Deng

5

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16 February 2020

William F Forrest

7

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16 February 2020

Mandy Kwong

8

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16 February 2020

Maj Hedehus

9

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16 February 2020

Georgia Hatzivassiliou

10

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Lori S Friedman

11

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16 February 2020

Heidi S Phillips

12

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16 February 2020

language of work or name

English

0 references

publication date

15 September 2014

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Proceedings of the National Academy of Sciences of the United States of America

16 February 2020

published in

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volume

111

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issue

39

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16 February 2020

page(s)

14217-14222

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The discovery of human of GLUD2 glutamate dehydrogenase and its implications for cell function in health and disease

16 February 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191757

Increased mitochondrial activity in a novel IDH1-R132H mutant human oligodendroglioma xenograft model: in situ detection of 2-HG and α-KG.

6 July 2018

1 reference

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BCAT1 promotes cell proliferation through amino acid catabolism in gliomas carrying wild-type IDH1.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191757

What a difference a hydroxyl makes: mutant IDH, (R)-2-hydroxyglutarate, and cancer

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191757

An inhibitor of mutant IDH1 delays growth and promotes differentiation of glioma cells.

6 July 2018

1 reference

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The definition of primary and secondary glioblastoma

6 July 2018

1 reference

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How cancer metabolism is tuned for proliferation and vulnerable to disruption

6 July 2018

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D-2-hydroxyglutarate produced by mutant IDH1 perturbs collagen maturation and basement membrane function

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191757

Cancer-associated isocitrate dehydrogenase mutations inactivate NADPH-dependent reductive carboxylation

6 July 2018

1 reference

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IDH mutation impairs histone demethylation and results in a block to cell differentiation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191757

The metabolic profile of tumors depends on both the responsible genetic lesion and tissue type.

6 July 2018

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Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of α-ketoglutarate to citrate to support cell growth and viability

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191757

Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191757

Reductive carboxylation supports growth in tumour cells with defective mitochondria.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191757

Ollier disease and Maffucci syndrome are caused by somatic mosaic mutations of IDH1 and IDH2.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191757

Somatic mosaic IDH1 and IDH2 mutations are associated with enchondroma and spindle cell hemangioma in Ollier disease and Maffucci syndrome

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191757

Evidence for sequenced molecular evolution of IDH1 mutant glioblastoma from a distinct cell of origin.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191757

IDH1 R132H decreases proliferation of glioma cell lines in vitro and in vivo

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191757

Inhibition of glutaminase preferentially slows growth of glioma cells with mutant IDH1.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191757

The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191757

Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191757

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191757

IDH1 and IDH2 hotspot mutations are not found in canine glioma.

6 July 2018

1 reference

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Glioblastoma cells require glutamate dehydrogenase to survive impairments of glucose metabolism or Akt signaling

6 July 2018

1 reference

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Understanding the Warburg effect: the metabolic requirements of cell proliferation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191757

IDH1 and IDH2 mutations in gliomas

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191757

An integrated genomic analysis of human glioblastoma multiforme

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191757

Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis

6 July 2018

1 reference

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Birth and adaptive evolution of a hominoid gene that supports high neurotransmitter flux

6 July 2018

1 reference

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PDGF autocrine stimulation dedifferentiates cultured astrocytes and induces oligodendrogliomas and oligoastrocytomas from neural progenitors and astrocytes in vivo

6 July 2018

1 reference

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Metabolism and role of glutamate in mammalian brain

6 July 2018

1 reference

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Good neighbours in the tumour stroma reduce oxidative stress

6 July 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25225364

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.1409653111

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16 February 2020

0 references

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16 February 2020

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