Targeting Toll-like receptor (TLR) signaling by Toll/interleukin-1 receptor (TIR) domain-containing adapter protein/MyD88 adapter-like (TIRAP/Mal)-derived decoy peptides. (Q34286955)

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English	Targeting Toll-like receptor (TLR) signaling by Toll/interleukin-1 receptor (TIR) domain-containing adapter protein/MyD88 adapter-like (TIRAP/Mal)-derived decoy peptides.	scientific article

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scholarly article

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2 February 2020

Targeting Toll-like receptor (TLR) signaling by Toll/interleukin-1 receptor (TIR) domain-containing adapter protein/MyD88 adapter-like (TIRAP/Mal)-derived decoy peptides (English)

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2 February 2020

toll-like receptor

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Vladimir Toshchakov

5

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2 February 2020

Stefanie N. Vogel

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Stefanie N Vogel

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Leah A Couture

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Wenji Piao

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Lisa W Ru

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30 May 2012

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Journal of Biological Chemistry

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287

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24641-24648

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29

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CD14 controls the LPS-induced endocytosis of Toll-like receptor 4

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Crystal structure of Toll-like receptor adaptor MAL/TIRAP reveals the molecular basis for signal transduction and disease protection

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The structural biology of Toll-like receptors

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Update on the role of Toll-like receptors during bacterial infections and sepsis

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Phagosomal retention of Francisella tularensis results in TIRAP/Mal-independent TLR2 signaling

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MyD88 adapter-like (Mal)/TIRAP interaction with TRAF6 is critical for TLR2- and TLR4-mediated NF-kappaB proinflammatory responses.

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Structure and regulation of cytoplasmic adapter proteins involved in innate immune signaling

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Structures of the toll-like receptor family and its ligand complexes

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The crystal structure of the human toll-like receptor 10 cytoplasmic domain reveals a putative signaling dimer

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TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-beta

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A dimer of the Toll-like receptor 4 cytoplasmic domain provides a specific scaffold for the recruitment of signalling adaptor proteins

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Cell-penetrating TIR BB loop decoy peptides a novel class of TLR signaling inhibitors and a tool to study topology of TIR-TIR interactions

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Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4.

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TLR4, but not TLR2, mediates IFN-beta-induced STAT1alpha/beta-dependent gene expression in macrophages.

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1 reference

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1 reference

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Differential involvement of BB loops of toll-IL-1 resistance (TIR) domain-containing adapter proteins in TLR4- versus TLR2-mediated signal transduction.

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Identifiers

10.1074/JBC.M112.360925

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2 February 2020

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2 February 2020

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