Cell-penetrating TIR BB loop decoy peptides a novel class of TLR signaling inhibitors and a tool to study topology of TIR-TIR interactions (Q36897400)

16 August 2017

1 reference

title

Cell-penetrating TIR BB loop decoy peptides a novel class of TLR signaling inhibitors and a tool to study topology of TIR-TIR interactions (English)

1 reference

16 August 2017

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Vladimir Y Toshchakov

series ordinal

1

1 reference

PubMed ID

17665992

16 August 2017

Stefanie N Vogel

series ordinal

2

1 reference

PubMed ID

17665992

16 August 2017

language of work or name

English

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publication date

1 July 2007

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Expert Opinion on Biological Therapy

16 August 2017

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16 August 2017

7

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16 August 2017

1035-1050

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16 August 2017

7

1 reference

Tolerance to microbial TLR ligands: molecular mechanisms and relevance to disease

16 August 2017

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Toll-like receptors in systemic autoimmune disease

21 January 2018

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Toll-like receptors and atherosclerosis: key contributors in disease and health?

21 January 2018

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Toll-like receptor modulation in cardiovascular disease: a target for intervention?

21 January 2018

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Therapeutic targeting of Toll-like receptors for inflammatory and infectious diseases.

21 January 2018

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Inhibition of nuclear factor kappa B (NF-B): an emerging theme in anti-inflammatory therapies

21 January 2018

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Protein transduction: cell penetrating peptides and their therapeutic applications

21 January 2018

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Intracellular delivery of large molecules and small particles by cell-penetrating proteins and peptides

21 January 2018

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Autonomous functional domains of chemically synthesized human immunodeficiency virus tat trans-activator protein

21 January 2018

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Cellular uptake of the tat protein from human immunodeficiency virus

21 January 2018

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Antennapedia homeobox peptide regulates neural morphogenesis

21 January 2018

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Intercellular trafficking and protein delivery by a herpesvirus structural protein

21 January 2018

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Cell-penetrating peptides: tools for intracellular delivery of therapeutics.

21 January 2018

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Transduction peptides: from technology to physiology

21 January 2018

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Membrane-permeable arginine-rich peptides and the translocation mechanisms

21 January 2018

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A linguistic model for the rational design of antimicrobial peptides.

21 January 2018

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Creation of novel cell-penetrating peptides for intracellular drug delivery using systematic phage display technology originated from Tat transduction domain

21 January 2018

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Functional cell permeable motifs within medically relevant proteins

21 January 2018

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Cell-penetrating peptides and antimicrobial peptides: how different are they?

21 January 2018

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Characterisation of cell-penetrating peptide-mediated peptide delivery

21 January 2018

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Toll-like receptor 4 signalling: new perspectives on a complex signal-transduction problem

21 January 2018

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Inhibition of Akt kinase activity by a peptide spanning the betaA strand of the proto-oncogene TCL1.

21 January 2018

1 reference

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Pseudosubstrate peptides inhibit Akt and induce cell growth inhibition

21 January 2018

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Selective inhibition of NF-kappaB activation by a peptide that blocks the interaction of NEMO with the IkappaB kinase complex

21 January 2018

1 reference

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Inhibition of NF-kappa B activation by peptides targeting NF-kappa B essential modulator (nemo) oligomerization

21 January 2018

1 reference

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Selective in vivo inhibition of mitogen-activated protein kinase activation using cell-permeable peptides

21 January 2018

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Identification of a peptide derived from vaccinia virus A52R protein that inhibits cytokine secretion in response to TLR-dependent signaling and reduces in vivo bacterial-induced inflammation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.7.1035

The poxvirus protein A52R targets Toll-like receptor signaling complexes to suppress host defense

21 January 2018

1 reference

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A novel inhibitory peptide of Toll-like receptor signaling limits lipopolysaccharide-induced production of inflammatory mediators and enhances survival in mice

21 January 2018

1 reference

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Targeting protein-protein interactions by rational design: mimicry of protein surfaces

21 January 2018

1 reference

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A low molecular weight mimic of the Toll/IL-1 receptor/resistance domain inhibits IL-1 receptor-mediated responses

21 January 2018

1 reference

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Concerted evolution of structure and function in a miniature protein

21 January 2018

1 reference

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Principles of protein-protein interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.7.1035

The atomic structure of protein-protein recognition sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.7.1035

Protein domain interfaces: characterization and comparison with oligomeric protein interfaces.

21 January 2018

1 reference

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Interactions of protein antigens with antibodies

21 January 2018

1 reference

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Structural evidence for induced fit as a mechanism for antibody-antigen recognition

21 January 2018

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TIRAP: an adapter molecule in the Toll signaling pathway

21 January 2018

1 reference

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TLR4, but not TLR2, mediates IFN-beta-induced STAT1alpha/beta-dependent gene expression in macrophages.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.7.1035

Differential involvement of BB loops of toll-IL-1 resistance (TIR) domain-containing adapter proteins in TLR4- versus TLR2-mediated signal transduction.

21 January 2018

1 reference

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Cutting Edge: Differential inhibition of TLR signaling pathways by cell-permeable peptides representing BB loops of TLRs.

21 January 2018

1 reference

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Toll-like receptor 4 and Toll-IL-1 receptor domain-containing adapter protein (TIRAP)/myeloid differentiation protein 88 adapter-like (Mal) contribute to maximal IL-6 expression in macrophages

21 January 2018

1 reference

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Role of water mediated interactions in protein-protein recognition landscapes

21 January 2018

1 reference

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Anatomy of hot spots in protein interfaces

21 January 2018

1 reference

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Hot regions in protein--protein interactions: the organization and contribution of structurally conserved hot spot residues.

21 January 2018

1 reference

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A human homologue of the Drosophila Toll protein signals activation of adaptive immunity

21 January 2018

1 reference

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A family of human receptors structurally related to Drosophila Toll

21 January 2018

1 reference

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Innate immune recognition

21 January 2018

1 reference

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Assembly of Cell Regulatory Systems Through Protein Interaction Domains

21 January 2018

1 reference

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TLRs: differential adapter utilization by toll-like receptors mediates TLR-specific patterns of gene expression

21 January 2018

1 reference

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SCOP: a structural classification of proteins database for the investigation of sequences and structures

21 January 2018

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The smallest known non-avian theropod dinosaur

21 January 2018

1 reference

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Crystal structure of human toll-like receptor 3 (TLR3) ectodomain

21 January 2018

1 reference

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The molecular structure of the Toll-like receptor 3 ligand-binding domain.

21 January 2018

1 reference

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The leucine-rich repeat as a protein recognition motif

21 January 2018

1 reference

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Pathogen recognition: TLRs throw us a curve

21 January 2018

1 reference

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Recognition of double-stranded RNA by human toll-like receptor 3 and downstream receptor signaling requires multimerization and an acidic pH.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.7.1035

The dsRNA binding site of human Toll-like receptor 3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.7.1035

Biochemical and functional analyses of the human Toll-like receptor 3 ectodomain. turtle nija occasionally

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.7.1035

Mycobacterial lipoarabinomannan mediates physical interactions between TLR1 and TLR2 to induce signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.7.1035

Importance of extra- and intracellular domains of TLR1 and TLR2 in NFkappa B signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.7.1035

Toll-like receptors as molecular switches.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.7.1035

Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.7.1035

Two tyrosine residues of Toll-like receptor 3 trigger different steps of NF-kappa B activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.7.1035

Cytoplasmic domain-mediated dimerizations of toll-like receptor 4 observed by beta-lactamase enzyme fragment complementation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.7.1035

Binding specificity of Toll-like receptor cytoplasmic domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.7.1035

MyD88, an adapter protein involved in interleukin-1 signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.7.1035

Murine TOLL-like receptor 4 confers lipopolysaccharide responsiveness as determined by activation of NF kappa B and expression of the inducible cyclooxygenase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.7.1035

The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between toll-like receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.7.1035

Discrimination of bacterial lipoproteins by Toll-like receptor 6

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.7.1035

Structural complementarity of Toll/interleukin-1 receptor domains in Toll-like receptors and the adaptors Mal and MyD88.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.7.1035

An analysis of conformational changes on protein-protein association: implications for predictive docking.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.7.1035

Details of Toll-like receptor:adapter interaction revealed by germ-line mutagenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.7.1035

Interactive sites in the MyD88 Toll/interleukin (IL) 1 receptor domain responsible for coupling to the IL1beta signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.7.1035

Identification of two major sites in the type I interleukin-1 receptor cytoplasmic region responsible for coupling to pro-inflammatory signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.7.1035

Structural and functional evidence for the role of the TLR2 DD loop in TLR1/TLR2 heterodimerization and signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.7.1035

An extensively associated dimer in the structure of the C713S mutant of the TIR domain of human TLR2

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.7.1035

The myristoylation of TRIF-related adaptor molecule is essential for Toll-like receptor 4 signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.7.1035

Phosphoinositide-mediated adaptor recruitment controls Toll-like receptor signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.7.1035

Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.7.1035

Endotoxin-tolerant mice have mutations in Toll-like receptor 4 (Tlr4)

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.7.1035

Common interaction surfaces of the toll-like receptor 4 cytoplasmic domain stimulate multiple nuclear targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.7.1035

Analysis of Tlr4-mediated LPS signal transduction in macrophages by mutational modification of the receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.7.1035

Toll-like receptor-2 mediates mycobacteria-induced proinflammatory signaling in macrophages.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.7.1035

LPS-TLR4 signaling to IRF-3/7 and NF-kappaB involves the toll adapters TRAM and TRIF

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.7.1035

The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.7.1035

Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.7.1035

Metabolic cleavage of cell-penetrating peptides in contact with epithelial models: human calcitonin (hCT)-derived peptides, Tat(47-57) and penetratin(43-58)

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.7.1035

Developing novel hCT derived cell-penetrating peptides with improved metabolic stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.7.1035

A D-amino acid peptide inhibitor of NF-kappa B nuclear localization is efficacious in models of inflammatory disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.7.1035

Complementarity of Structure Ensembles in Protein-Protein Binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.7.1035

10.1517/14712598.7.7.1035

21 January 2018

Identifiers

DOI

1 reference

16 August 2017

1 reference

PubMed ID

17665992