Amyloid precursor protein (APP) and the biology of proteolytic processing: relevance to Alzheimer's disease (Q34208401)

31 July 2017

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title

Amyloid precursor protein (APP) and the biology of proteolytic processing: relevance to Alzheimer's disease (English)

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31 July 2017

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Kevin Morgan

2

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author name string

Yan Ling

series ordinal

1

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PubMed ID

12824062

31 July 2017

Noor Kalsheker

series ordinal

3

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31 July 2017

1 November 2003

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International Journal of Biochemistry & Cell Biology

31 July 2017

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31 July 2017

35

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31 July 2017

1505-1535

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31 July 2017

11

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Substantial linkage disequilibrium across the insulin-degrading enzyme locus but no association with late-onset Alzheimer's disease.

31 July 2017

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Immunochemical identification of the serine protease inhibitor alpha 1-antichymotrypsin in the brain amyloid deposits of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

The gene encoding DRAP (BACE2), a glycosylated transmembrane protein of the aspartic protease family, maps to the down critical region

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Human insulin-degrading enzyme shares structural and functional homologies with E. coli protease III

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Insulin-degrading enzyme: stable expression of the human complementary DNA, characterization of its protein product, and chromosomal mapping of the human and mouse genes

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Excessive urokinase-type plasminogen activator activity in the euglobulin fraction of patients with Alzheimer-type dementia.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Presenilin 1 controls gamma-secretase processing of amyloid precursor protein in pre-golgi compartments of hippocampal neurons

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Presenilin-1 binds cytoplasmic epithelial cadherin, inhibits cadherin/p120 association, and regulates stability and function of the cadherin/catenin adhesion complex

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Molecular evolution of serpins: homologous structure of the human alpha 1-antichymotrypsin and alpha 1-antitrypsin genes.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Apolipoprotein E isoforms in Alzheimer's disease pathology and etiology

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

The LDL-receptor-related protein, LRP, is an apolipoprotein E-binding protein

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Post-translational processing of beta-secretase (beta-amyloid-converting enzyme) and its ectodomain shedding. The pro- and transmembrane/cytosolic domains affect its cellular activity and amyloid-beta production

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

A furin-like convertase mediates propeptide cleavage of BACE, the Alzheimer's beta -secretase

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Insulin-degrading enzyme in the Alzheimer's disease brain: prominent localization in neurons and senile plaques.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Evidence for genetic linkage of Alzheimer's disease to chromosome 10q

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

CD91: a receptor for heat shock protein gp96

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

A metalloproteinase disintegrin that releases tumour-necrosis factor-alpha from cells

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Alpha-2 macroglobulin is genetically associated with Alzheimer disease.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Metalloprotease-disintegrins: links to cell adhesion and cleavage of TNF alpha and Notch

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Expression of human beta-secretase in the mouse brain increases the steady-state level of beta-amyloid.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

A splice variant of beta-secretase deficient in the amyloidogenic processing of the amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Protein phosphorylation inhibits production of Alzheimer amyloid beta/A4 peptide

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Evidence that tumor necrosis factor alpha converting enzyme is involved in regulated alpha-secretase cleavage of the Alzheimer amyloid protein precursor

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

BACE1 is the major beta-secretase for generation of Abeta peptides by neurons

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

The proteolytic fragments of the Alzheimer's disease-associated presenilin-1 form heterodimers and occur as a 100-150-kDa molecular mass complex

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Maturation and pro-peptide cleavage of beta-secretase

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Beta-amyloid catabolism: roles for neprilysin (NEP) and other metallopeptidases?

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Enzymatically active lysosomal proteases are associated with amyloid deposits in Alzheimer brain

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Sequence homology between human alpha 1-antichymotrypsin, alpha 1-antitrypsin, and antithrombin III.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Characterization of the glycosylation profiles of Alzheimer's beta -secretase protein Asp-2 expressed in a variety of cell lines.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Nicastrin binds to membrane-tethered Notch

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Uptake, degradation, and release of fibrillar and soluble forms of Alzheimer's amyloid beta-peptide by microglial cells.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Neuroendocrine differentiation, neuropeptides, and neprilysin

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

[alpha]-Secretase ADAM10 as well as [alpha]APPs is reduced in platelets and CSF of Alzheimer disease patients

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Expression and analysis of presenilin 1 in a human neuronal system: localization in cell bodies and dendrites

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Processing of beta-secretase by furin and other members of the proprotein convertase family

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Organization of the gene encoding common acute lymphoblastic leukemia antigen (neutral endopeptidase 24.11): multiple miniexons and separate 5' untranslated regions

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Oligomeric and fibrillar species of amyloid-beta peptides differentially affect neuronal viability.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Peripheral anti-A beta antibody alters CNS and plasma A beta clearance and decreases brain A beta burden in a mouse model of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Phosphorylation, subcellular localization, and membrane orientation of the Alzheimer's disease-associated presenilins.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Alzheimer-associated presenilin-2 confers increased sensitivity to apoptosis in PC12 cells

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Cell surface expression of the Alzheimer disease-related presenilin proteins

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Spotlight on BACE: the secretases as targets for treatment in Alzheimer disease

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Mice lacking both presenilin genes exhibit early embryonic patterning defects

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Alpha-2 macroglobulin polymorphism and Alzheimer disease risk in the UK.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Insulin-degrading enzyme rapidly removes the beta-amyloid precursor protein intracellular domain (AICD)

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Presenilin and nicastrin regulate each other and determine amyloid beta-peptide production via complex formation

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Splice variants of the beta-site APP-cleaving enzyme BACE1 in human brain and pancreas

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Alpha 1-antichymotrypsin regulates Alzheimer beta-amyloid peptide fibril formation

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Linkage of plasma Abeta42 to a quantitative locus on chromosome 10 in late-onset Alzheimer's disease pedigrees

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Localization of the gene encoding insulin-degrading enzyme to human chromosome 10, bands q23→q25

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Apolipoprotein E is a kinetic but not a thermodynamic inhibitor of amyloid formation: implications for the pathogenesis and treatment of Alzheimer disease

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Alpha-antichymotrypsin gene polymorphism and risk for Alzheimer's disease in the Spanish population.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Nicastrin, a presenilin-interacting protein, contains an aminopeptidase/transferrin receptor superfamily domain

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Alpha-secretase activity of the disintegrin metalloprotease ADAM 10. Influences of domain structure

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

BACE2, a beta -secretase homolog, cleaves at the beta site and within the amyloid-beta region of the amyloid-beta precursor protein

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

The disulphide bonds in the catalytic domain of BACE are critical but not essential for amyloid precursor protein processing activity

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

A non-amyloidogenic function of BACE-2 in the secretory pathway

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Differential effects of the swedish mutant amyloid precursor protein on beta-amyloid accumulation and secretion in neurons and nonneuronal cells

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

?1-Antichymotrypsin Binding to Alzheimer A? Peptides Is Sequence Specific and Induces Fibril Disaggregation In Vitro

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

The polymorphic human alpha 2-macroglobulin gene (A2M) is located in chromosome region 12p12.3----p13.3.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Inhibition of beta-amyloid production by activation of protein kinase C.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Expression of caveolin-1 and -2 in differentiating PC12 cells and dorsal root ganglion neurons: caveolin-2 is up-regulated in response to cell injury

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Abeta-peptide length and apolipoprotein E genotype in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Characterization and chromosomal localization of a cDNA encoding brain amyloid of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Genetics leads the way to the accomplices of presenilins

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Alzheimer's presenilin mutation sensitizes neural cells to apoptosis induced by trophic factor withdrawal and amyloid beta-peptide: involvement of calcium and oxyradicals.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Amyloid beta-peptide is produced by cultured cells during normal metabolism

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

No genetic effect of alpha1-antichymotrypsin in Alzheimer disease.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Characterization of Alzheimer's beta -secretase protein BACE. A pepsin family member with unusual properties

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

BACE1 interacts with nicastrin

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Total inactivation of gamma-secretase activity in presenilin-deficient embryonic stem cells.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

LRP: a multifunctional scavenger and signaling receptor

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Assignment of mouse alpha-2-macroglobulin gene to chromosome 6 band F1-G3

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

The alternatively spliced Kunitz protease inhibitor domain alters amyloid beta protein precursor processing and amyloid beta protein production in cultured cells.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Role of apoe/Abeta interactions in the pathogenesis of Alzheimer's disease and cerebral amyloid angiopathy

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Structure of the protease domain of memapsin 2 (beta-secretase) complexed with inhibitor

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

The search for alpha-secretase and its potential as a therapeutic approach to Alzheimer s disease

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

A secreted form of human ADAM9 has an alpha-secretase activity for APP

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Molecular cloning of MADM: a catalytically active mammalian disintegrin-metalloprotease expressed in various cell types

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

In search of an enzyme: the beta-secretase of Alzheimer's disease is an aspartic proteinase

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Alpha2-macroglobulin associates with beta-amyloid peptide and prevents fibril formation

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Embryonic lethality in mice homozygous for a processing-deficient allele of Notch1.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Closing in on the amyloid cascade: recent insights into the cell biology of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Beta-secretase processing in the trans-Golgi network preferentially generates truncated amyloid species that accumulate in Alzheimer's disease brain

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Maturation and endosomal targeting of beta-site amyloid precursor protein-cleaving enzyme. The Alzheimer's disease beta-secretase

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

ASP1 (BACE2) cleaves the amyloid precursor protein at the beta-secretase site

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Identification of a Novel Aspartic Protease (Asp 2) as β-Secretase

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Caveolae, plasma membrane microdomains for alpha-secretase-mediated processing of the amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Affinity-purification and characterization of caveolins from the brain: differential expression of caveolin-1, -2, and -3 in brain endothelial and astroglial cell types.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Absence of association of alpha1-antichymotrypsin polymorphisms with Alzheimer's disease: a report on autopsy-confirmed cases.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Metabolic regulation of brain Abeta by neprilysin.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

A specific structural interaction of Alzheimer's peptide A beta 1-42 with alpha 1-antichymotrypsin.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Alzheimer's peptide Abeta1-42 binds to two beta-sheets of alpha1-antichymotrypsin and transforms it from inhibitor to substrate.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Increased apoptosis arising from increased expression of the Alzheimer's disease-associated presenilin-2 mutation (N141I).

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

The C-terminus of the beta protein is critical in amyloidogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Fine mapping of an Alzheimer disease-associated gene encoding beta-amyloid protein.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Alpha 1-antichymotrypsin

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Presenilin-1 affects trafficking and processing of betaAPP and is targeted in a complex with nicastrin to the plasma membrane

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Kinesin-mediated axonal transport of a membrane compartment containing beta-secretase and presenilin-1 requires APP

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

APOE*4-associated Alzheimer's disease risk is modified by alpha 1-antichymotrypsin polymorphism.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Nucleotide sequence of cDNA encoding human alpha 2-macroglobulin and assignment of the chromosomal locus

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Modulation of amyloid beta-protein clearance and Alzheimer's disease susceptibility by the LDL receptor-related protein pathway.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Genetic association of the low-density lipoprotein receptor-related protein gene (LRP), an apolipoprotein E receptor, with late-onset Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Presenilin-1 mutations downregulate the signalling pathway of the unfolded-protein response

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Inhibitory effect of a presenilin 1 mutation on the Wnt signalling pathway by enhancement of beta-catenin phosphorylation

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

A full genome scan for late onset Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Correlation between beta-amyloid peptide production and human APP-induced neuronal death

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Negative regulation of the SAPK/JNK signaling pathway by presenilin 1

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Endoproteolytic cleavage and proteasomal degradation of presenilin 2 in transfected cells

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Complex N-linked glycosylated nicastrin associates with active gamma-secretase and undergoes tight cellular regulation

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Structural biochemistry and activation of matrix metalloproteases

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Cell surface APP751 forms complexes with protease nexin 2 ligands and is internalized via the low density lipoprotein receptor-related protein (LRP).

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Membrane-anchored metalloprotease MDC9 has an alpha-secretase activity responsible for processing the amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Low cholesterol stimulates the nonamyloidogenic pathway by its effect on the alpha -secretase ADAM 10.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Aph-2/Nicastrin: an essential component of gamma-secretase and regulator of Notch signaling and Presenilin localization

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Mechanism of interleukin-1- and tumor necrosis factor alpha-dependent regulation of the alpha 1-antichymotrypsin gene in human astrocytes

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Oncostatin M and the interleukin-6 and soluble interleukin-6 receptor complex regulate alpha1-antichymotrypsin expression in human cortical astrocytes.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

The Alzheimer amyloid precursor protein maps to human chromosome 21 bands q21.105-q21.05.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

alpha2-macroglobulin in late-onset Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Evidence that the newly cloned low-density-lipoprotein receptor related protein (LRP) is the alpha 2-macroglobulin receptor.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Separation of presenilin function in amyloid beta-peptide generation and endoproteolysis of Notch

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Amyloidogenic determinant as a substrate recognition motif of insulin-degrading enzyme.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Insulin-degrading enzyme: embarking on amyloid destruction.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Alzheimer's beta-amyloid peptide specifically interacts with and is degraded by insulin degrading enzyme

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Endogenous presenilin-1 targets to endocytic rather than biosynthetic compartments

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Apolipoprotein E and alpha-1 antichymotrypsin polymorphism genotyping in Alzheimer's disease and in dementia with Lewy bodies. Distinctions between diseases.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Effect of the APOE promoter polymorphisms on cerebral amyloid peptide deposition in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

The -48 C/T polymorphism in the presenilin 1 promoter is associated with an increased risk of developing Alzheimer's disease and an increased Abeta load in brain.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Constitutive and regulated alpha-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Brain plasmin enhances APP alpha-cleavage and Abeta degradation and is reduced in Alzheimer's disease brains

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

A detergent-insoluble membrane compartment contains A beta in vivo.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Presenilin 1 is required for maturation and cell surface accumulation of nicastrin

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Genomic structure and expression of STM2, the chromosome 1 familial Alzheimer disease gene

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Candidate gene for the chromosome 1 familial Alzheimer's disease locus

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

A familial Alzheimer's disease locus on chromosome 1.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Additional evidence for an eight-transmembrane-domain topology for Caenorhabditis elegans and human presenilins

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Alzheimer presenilins in the nuclear membrane, interphase kinetochores, and centrosomes suggest a role in chromosome segregation

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Genetic association of an alpha2-macroglobulin (Val1000lle) polymorphism and Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Gene polymorphism affecting α1-antichymotrypsin and interleukin-1 plasma levels increases Alzheimer's disease risk

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Apolipoprotein E and alpha-1-antichymotrypsin allele polymorphism in sporadic and familial Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Glu11 site cleavage and N-terminally truncated A beta production upon BACE overexpression

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Alzheimer A beta neurotoxicity: promotion by antichymotrypsin, ApoE4; inhibition by A beta-related peptides

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Amyloid-associated proteins α1-antichymotrypsin and apolipoprotein E promote assembly of Alzheimer β-protein into filaments

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Association of alpha(1)-antichymotrypsin deficiency with milder lung disease in patients with cystic fibrosis

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Potential novel targets for Alzheimer pharmacotherapy: I. Secretases

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Coordinated Expression of β-Amyloid Precursor Protein and the Putative β-Secretase BACE and α-Secretase ADAM10 in Mouse and Human Brain

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Structure of the human alpha-2 macroglobulin gene and its promotor

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

A deletion polymorphism in the human alpha-2-macroglobulin (A2M) gene

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Proteolytic processing of low density lipoprotein receptor-related protein mediates regulated release of its intracellular domain

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Susceptibility locus for Alzheimer's disease on chromosome 10.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Relative increase in Alzheimer's disease of soluble forms of cerebral Abeta amyloid protein precursor containing the Kunitz protease inhibitory domain.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Neuroinflammation and anti-inflammatory therapy for Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Polymorphism in the alpha(1)-antichymotrypsin (ACT) gene promoter: effect on expression in transfected glial and liver cell lines and plasma ACT concentrations

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Structural features and biochemical properties of TNF-alpha converting enzyme (TACE).

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Elevated expression of beta-site amyloid precursor protein cleaving enzyme 2 in brains of patients with Down syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

High-level neuronal expression of abeta 1-42 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formation

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Astroglial expression of human alpha(1)-antichymotrypsin enhances alzheimer-like pathology in amyloid protein precursor transgenic mice

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

No association between the alpha 1-antichymotrypsin A allele and Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Presenilin 1 regulates pharmacologically distinct gamma -secretase activities. Implications for the role of presenilin in gamma -secretase cleavage

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

The gene for the human putative apoE receptor is on chromosome 12 in the segment q13-14.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Genetic association of alpha2-macroglobulin with Alzheimer's disease in a Finnish elderly population

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Implication of α1-antichymotrypsin polymorphism in familial Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Alpha2-macroglobulin complexes with and mediates the endocytosis of beta-amyloid peptide via cell surface low-density lipoprotein receptor-related protein.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Effects of PS1 deficiency on membrane protein trafficking in neurons.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Correlation between elevated levels of amyloid beta-peptide in the brain and cognitive decline

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Relative abundance of Alzheimer A beta amyloid peptide variants in Alzheimer disease and normal aging

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Alpha-1-antichymotrypsin promotes beta-sheet amyloid plaque deposition in a transgenic mouse model of Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Release of Alzheimer amyloid precursor derivatives stimulated by activation of muscarinic acetylcholine receptors

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

A role for presenilin-1 in nuclear accumulation of Ire1 fragments and induction of the mammalian unfolded protein response

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Posttranslational modification and plasma membrane localization of the Drosophila melanogaster presenilin.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Regulation of APP cleavage by alpha-, beta- and gamma-secretases

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Dinucleotide repeat polymorphisms in the neprilysin gene are not associated with sporadic Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

The secretases that cleave angiotensin converting enzyme and the amyloid precursor protein are distinct from tumour necrosis factor-alpha convertase.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Mapping of the gene encoding the beta-amyloid precursor protein and its relationship to the Down syndrome region of chromosome 21

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Degradation of soluble amyloid beta-peptides 1-40, 1-42, and the Dutch variant 1-40Q by insulin degrading enzyme from Alzheimer disease and control brains.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

The beta-amyloid precursor protein of Alzheimer's disease enhances neuron viability and modulates neuronal polarity

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Proteolysis in Alzheimer's disease. Can plasmin tip the balance?

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

New protease inhibitors prevent gamma-secretase-mediated production of Abeta40/42 without affecting Notch cleavage

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Amino-terminal deletions enhance aggregation of beta-amyloid peptides in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Degradation of amyloid beta-protein by a serine protease-alpha2-macroglobulin complex.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Insulin-degrading enzyme regulates extracellular levels of amyloid beta-protein by degradation

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Endoproteolytic processing and stabilization of wild-type and mutant presenilin

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Cell surface presenilin-1 participates in the gamma-secretase-like proteolysis of Notch

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Molecular cloning and characterization of a cDNA encoding the cerebrovascular and the neuritic plaque amyloid peptides

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Analysis of the 5' sequence, genomic structure, and alternative splicing of the presenilin-1 gene (PSEN1) associated with early onset Alzheimer disease

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

An alpha-2-macroglobulin insertion-deletion polymorphism in Alzheimer disease.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Inflammation and Alzheimer's disease pathogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Implications of amyloid precursor protein and subsequent beta-amyloid production to the pharmacotherapy of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Alpha-2 macroglobulin gene and Alzheimer disease.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Apolipoprotein E associates with beta amyloid peptide of Alzheimer's disease to form novel monofibrils. Isoform apoE4 associates more efficiently than apoE3

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Alzheimer's disease. A partner for presenilin.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Protease nexin-2/amyloid beta protein precursor. A tight-binding inhibitor of coagulation factor IXa.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Endogenous presenilin 1 redistributes to the surface of lamellipodia upon adhesion of Jurkat cells to a collagen matrix

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Proprotein and prohormone convertases: a family of subtilases generating diverse bioactive polypeptides

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Alzheimer's disease: genes, proteins, and therapy

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Clearing the brain's amyloid cobwebs

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Alzheimer's disease: molecular understanding predicts amyloid-based therapeutics

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Secretion of beta-amyloid precursor protein cleaved at the amino terminus of the beta-amyloid peptide

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Isolation and quantification of soluble Alzheimer's beta-peptide from biological fluids

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Skeletal and CNS defects in Presenilin-1-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

The pro domain of beta-secretase does not confer strict zymogen-like properties but does assist proper folding of the protease domain

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Clearance of Alzheimer's amyloid-ss(1-40) peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Production of the Alzheimer amyloid beta protein by normal proteolytic processing

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Cholesterol depletion inhibits the generation of beta-amyloid in hippocampal neurons

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

The role of Alzheimer's disease-related presenilin 1 in intercellular adhesion

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Purification and cloning of amyloid precursor protein beta-secretase from human brain

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Constitutive shedding of the amyloid precursor protein ectodomain is up-regulated by tumour necrosis factor-alpha converting enzyme

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Is gamma-secretase a multienzyme complex for membrane protein degradation? Models and speculations

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Regulation of brain G-protein go by Alzheimer's disease gene presenilin-1.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

A new aspartyl protease on 21q22.3, BACE2, is highly similar to Alzheimer's amyloid precursor protein beta-secretase

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Proteolytic release and nuclear translocation of Notch-1 are induced by presenilin-1 and impaired by pathogenic presenilin-1 mutations

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Analysis of the subsite specificity of rat insulysin using fluorogenic peptide substrates

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Intramembrane proteolysis by presenilins

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Presenilin is required for activity and nuclear access of Notch in Drosophila

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Alpha1-antichymotrypsin/Alzheimer's peptide Abeta(1-42) complex perturbs lipid metabolism and activates transcription factors PPARgamma and NFkappaB in human neuroblastoma (Kelly) cells

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Glioma cell activation by Alzheimer's peptide Abeta1-42, alpha1-antichymotrypsin, and their mixture

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Three novel alternatively spliced isoforms of the human beta-site amyloid precursor protein cleaving enzyme (BACE) and their effect on amyloid beta-peptide production

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Structural evidence for gene duplication in the evolution of the acid proteases

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Caspases land on APP: one small step for apoptosis, one giant leap for amyloidosis?

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

New frontiers in Alzheimer's disease genetics

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Protease inhibitor domain encoded by an amyloid protein precursor mRNA associated with Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Genetic variability in the regulatory region of presenilin 1 associated with risk for Alzheimer's disease and variable expression

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Evidence that levels of presenilins (PS1 and PS2) are coordinately regulated by competition for limiting cellular factors.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Alpha-1-antichymotrypsin bi-allele polymorphism, apolipoprotein-E tri-allele polymorphism and genetic risk of Alzheimer's syndrome.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Complex N-glycosylated form of nicastrin is stabilized and selectively bound to presenilin fragments.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

The presenilin 2 mutation (N141I) linked to familial Alzheimer disease (Volga German families) increases the secretion of amyloid beta protein ending at the 42nd (or 43rd) residue

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

The common acute lymphoblastic leukemia antigen (neutral endopeptidase-3.4.24.11) gene is located on human chromosome 3.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Human plasma proteinase inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Interaction of cytosolic adaptor proteins with neuronal apolipoprotein E receptors and the amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

The plasmin system is induced by and degrades amyloid-beta aggregates

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

The neprilysin (NEP) family of zinc metalloendopeptidases: genomics and function

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Modulation of beta-amyloid precursor protein processing by the low density lipoprotein receptor-related protein (LRP). Evidence that LRP contributes to the pathogenesis of Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Targeted inactivation of the mouse alpha 2-macroglobulin gene

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

alpha 2-Macroglobulin expression in neuritic-type plaques in patients with Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Plasmin cleavage of the amyloid beta-protein: alteration of secondary structure and stimulation of tissue plasminogen activator activity

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

The beta-secretase, BACE: a prime drug target for Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Generation of anti-apoptotic presenilin-2 polypeptides by alternative transcription, proteolysis, and caspase-3 cleavage

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Requirement of the familial Alzheimer's disease gene PS2 for apoptosis. Opposing effect of ALG-3

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Distribution of plasma alpha 1-antichymotrypsin levels in Alzheimer disease patients and controls and their genetic controls.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Genetic variation in alpha(1)-antichymotrypsin and its association with Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Apolipoprotein E is a genetic risk factor for fetal iodine deficiency disorder in China

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Are presenilins intramembrane-cleaving proteases? Implications for the molecular mechanism of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Participation of presenilin 2 in apoptosis: enhanced basal activity conferred by an Alzheimer mutation

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Presenilin 1 is required for Notch1 and DII1 expression in the paraxial mesoderm

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

BACE2 functions as an alternative alpha-secretase in cells

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Mature glycosylation and trafficking of nicastrin modulate its binding to presenilins

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

alpha 1-Antichymotrypsin as a risk modifier for late-onset Alzheimer's disease in Japanese apolipoprotein E epsilon 4 allele carriers.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Genomic organization of the human amyloid beta-protein precursor gene

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Amyloid beta vaccination: reduced plaques and improved cognition.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

The presenilin 1 protein is a component of a high molecular weight intracellular complex that contains beta-catenin

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

Subcellular distribution and turnover of presenilins in transfected cells

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

A genome survey for novel Alzheimer disease risk loci: results at 10-cM resolution.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2803%2900133-X

7 January 2021

10.1016/S1357-2725(03)00133-X

Identifiers

DOI

1 reference

release_d2sj6c2vlbed5m65jf3dmkzglq

31 July 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/d2sj6c2vlbed5m65jf3dmkzglq

24 November 2022

mapped directly with Wikidata item

PubMed ID

12824062

1 reference

PubMed ID

12824062