Regulation of APP cleavage by alpha-, beta- and gamma-secretases (Q34061109)

30 July 2017

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title

Regulation of APP cleavage by alpha-, beta- and gamma-secretases (English)

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30 July 2017

Nunan J

1

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PubMed ID

11033346

30 July 2017

Small DH

series ordinal

2

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PubMed ID

11033346

30 July 2017

language of work or name

English

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publication date

1 October 2000

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30 July 2017

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30 July 2017

483

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30 July 2017

1

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30 July 2017

6-10

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Alzheimer's disease: a description of the structural lesions

30 July 2017

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The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

21 January 2018

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Regulation of amyloid precursor protein cleavage.

21 January 2018

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Alzheimer's disease and the amyloid beta protein: What is the role of amyloid?

21 January 2018

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Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

21 January 2018

1 reference

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Water-soluble Abeta (N-40, N-42) oligomers in normal and Alzheimer disease brains.

21 January 2018

1 reference

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Transgenic animals relevant to Alzheimer's disease

21 January 2018

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Alzheimer disease: mouse models pave the way for therapeutic opportunities

21 January 2018

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Seeding "one-dimensional crystallization" of amyloid: a pathogenic mechanism in Alzheimer's disease and scrapie?

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2800%2902076-7

Cleavage of amyloid beta peptide during constitutive processing of its precursor

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2800%2902076-7

The role of the amyloid protein precursor (APP) in Alzheimer's disease: does the normal function of APP explain the topography of neurodegeneration?

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2800%2902076-7

Release of Alzheimer amyloid precursor derivatives stimulated by activation of muscarinic acetylcholine receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2800%2902076-7

The Alzheimer beta-amyloid protein precursor/protease nexin-II is cleaved by secretase in a trans-Golgi secretory compartment in human neuroglioma cells

21 January 2018

1 reference

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Constitutive and regulated alpha-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease

21 January 2018

1 reference

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The Swedish mutation causes early-onset Alzheimer's disease by beta-secretase cleavage within the secretory pathway

21 January 2018

1 reference

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Protein kinase C-dependent alpha-secretase competes with beta-secretase for cleavage of amyloid-beta precursor protein in the trans-golgi network

21 January 2018

1 reference

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Cellular mechanisms of beta-amyloid production and secretion

21 January 2018

1 reference

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Evidence that tumor necrosis factor alpha converting enzyme is involved in regulated alpha-secretase cleavage of the Alzheimer amyloid protein precursor

21 January 2018

1 reference

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Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

21 January 2018

1 reference

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Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity

21 January 2018

1 reference

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Purification and cloning of amyloid precursor protein beta-secretase from human brain

21 January 2018

1 reference

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Identification of a Novel Aspartic Protease (Asp 2) as β-Secretase

21 January 2018

1 reference

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Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2800%2902076-7

Characterization of Alzheimer's beta -secretase protein BACE. A pepsin family member with unusual properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2800%2902076-7

BACE2, a beta -secretase homolog, cleaves at the beta site and within the amyloid-beta region of the amyloid-beta precursor protein

21 January 2018

1 reference

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Expression analysis of BACE2 in brain and peripheral tissues

21 January 2018

1 reference

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The potential of BACE inhibitors for Alzheimer's therapy

21 January 2018

1 reference

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Biology of presenilins as causative molecules for Alzheimer disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2800%2902076-7

Monogenic determinants of familial Alzheimer's disease: presenilin-1 mutations

21 January 2018

1 reference

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Total inactivation of gamma-secretase activity in presenilin-deficient embryonic stem cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2800%2902076-7

Distinct sites of intracellular production for Alzheimer's disease A beta40/42 amyloid peptides.

21 January 2018

1 reference

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Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state

21 January 2018

1 reference

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Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

21 January 2018

1 reference

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Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1.

21 January 2018

1 reference

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Interaction between amyloid precursor protein and presenilins in mammalian cells: implications for the pathogenesis of Alzheimer disease

21 January 2018

1 reference

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Formation of stable complexes between two Alzheimer's disease gene products: presenilin-2 and beta-amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2800%2902076-7

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

21 January 2018

1 reference

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A loss of function mutation of presenilin-2 interferes with amyloid beta-peptide production and notch signaling

21 January 2018

1 reference

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Are presenilins intramembrane-cleaving proteases? Implications for the molecular mechanism of Alzheimer's disease

21 January 2018

1 reference

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Presenilin-1 differentially facilitates endoproteolysis of the beta-amyloid precursor protein and Notch

21 January 2018

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Regulated intramembrane proteolysis: a control mechanism conserved from bacteria to humans

21 January 2018

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Notch signaling: cell fate control and signal integration in development

21 January 2018

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Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse

21 January 2018

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Muscarinic M1 receptor agonists increase the secretion of the amyloid precursor protein ectodomain

21 January 2018

1 reference

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Differential effects of the swedish mutant amyloid precursor protein on beta-amyloid accumulation and secretion in neurons and nonneuronal cells

7 January 2021

1 reference

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Peptidomimetic probes and molecular modeling suggest that Alzheimer's gamma-secretase is an intramembrane-cleaving aspartyl protease

7 January 2021

1 reference

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10.1016/S0014-5793(00)02076-7

7 January 2021

Identifiers

DOI

1 reference

30 July 2017

1 reference

PubMed ID

11033346