Tie receptors: new modulators of angiogenic and lymphangiogenic responses (Q34205564)

31 July 2017

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title

Tie receptors: new modulators of angiogenic and lymphangiogenic responses (English)

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31 July 2017

Tie signaling pathway

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Gene Ontology release 2020-05-02

K Alitalo

4

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author name string

N Jones

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1

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31 July 2017

K Iljin

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2

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31 July 2017

D J Dumont

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3

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31 July 2017

1 April 2001

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Nature Reviews Molecular Cell Biology

31 July 2017

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31 July 2017

2

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31 July 2017

257-267

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31 July 2017

4

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https://scigraph.springernature.com/pub.10.1038/35067005

31 July 2017

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Induction of tumor lymphangiogenesis by VEGF-C promotes breast cancer metastasis

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Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning

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Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis

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Angiopoietins 3 and 4: diverging gene counterparts in mice and humans

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Dominant-negative and targeted null mutations in the endothelial receptor tyrosine kinase, tek, reveal a critical role in vasculogenesis of the embryo

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Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formation

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Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis

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TIE1 and TIE2 receptor tyrosine kinases inversely regulate embryonic angiogenesis by the mechanism of intussusceptive microvascular growth

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The receptor tyrosine kinase TIE is required for integrity and survival of vascular endothelial cells.

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Increased vascularization in mice overexpressing angiopoietin-1

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Leakage-resistant blood vessels in mice transgenically overexpressing angiopoietin-1

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Rescue of the early vascular defects in Tek/Tie2 null mice reveals an essential survival function

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Tie2 expression and phosphorylation in angiogenic and quiescent adult tissues.

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Vascular endothelial growth factor acts as a survival factor for newly formed retinal vessels and has implications for retinopathy of prematurity

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Cell type-specific expression of angiopoietin-1 and angiopoietin-2 suggests a role in glioblastoma angiogenesis

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In situ expression of angiopoietins in astrocytomas identifies angiopoietin-2 as an early marker of tumor angiogenesis.

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Expression of Tie1, Tie2, and angiopoietins 1, 2, and 4 in Kaposi's sarcoma and cutaneous angiosarcoma

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Tie2 receptor ligands, angiopoietin-1 and angiopoietin-2, modulate VEGF-induced postnatal neovascularization

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Biological action of angiopoietin-2 in a fibrin matrix model of angiogenesis is associated with activation of Tie2.

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7 January 2021

Angiopoietin-2 at high concentration can enhance endothelial cell survival through the phosphatidylinositol 3'-kinase/Akt signal transduction pathway

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Vascular dysmorphogenesis caused by an activating mutation in the receptor tyrosine kinase TIE2

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Allelic and locus heterogeneity in inherited venous malformations

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Endothelial receptor tyrosine kinases activate the STAT signaling pathway: mutant Tie-2 causing venous malformations signals a distinct STAT activation response

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Endothelial Tie growth factor receptor provides antigenic marker for assessment of breast cancer angiogenesis

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Expression of Tie2/Tek in breast tumour vasculature provides a new marker for evaluation of tumour angiogenesis

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Analysis of Tie receptor tyrosine kinase in haemopoietic progenitor and leukaemia cells

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Hypoxia and vascular endothelial growth factor selectively up-regulate angiopoietin-2 in bovine microvascular endothelial cells

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Regulation of angiopoietin-2 mRNA levels in bovine microvascular endothelial cells by cytokines and hypoxia.

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The endothelial receptor tyrosine kinase tie-1 is upregulated by hypoxia and vascular endothelial growth factor.

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Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells

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Tie2 receptor expression is stimulated by hypoxia and proinflammatory cytokines in human endothelial cells

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Uniform vascular-endothelial-cell-specific gene expression in both embryonic and adult transgenic mice

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Role of ets factors in the activity and endothelial cell specificity of the mouse Tie gene promoter.

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Antiangiogenic gene therapy targeting the endothelium-specific receptor tyrosine kinase Tie2

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Inhibition of tumor angiogenesis using a soluble receptor establishes a role for Tie2 in pathologic vascular growth

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Glioblastoma growth inhibited in vivo by a dominant-negative Flk-1 mutant

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Identification of Tek/Tie2 binding partners. Binding to a multifunctional docking site mediates cell survival and migration

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Angiopoietin-1 induces sprouting angiogenesis in vitro

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7 January 2021

Chemotactic properties of angiopoietin-1 and -2, ligands for the endothelial-specific receptor tyrosine kinase Tie2

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Angiopoietin-1 is an apoptosis survival factor for endothelial cells

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Tyrosine 1101 of Tie2 is the major site of association of p85 and is required for activation of phosphatidylinositol 3-kinase and Akt

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7 January 2021

Role of PI 3-kinase in angiopoietin-1-mediated migration and attachment-dependent survival of endothelial cells

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Angiopoietin-1 regulates endothelial cell survival through the phosphatidylinositol 3'-Kinase/Akt signal transduction pathway

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Angiopoietin-1 and its receptor Tie-2 participate in the regulation of capillary-like tubule formation and survival of endothelial cells

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Phosphatidylinositol 3-kinase signaling mediates angiogenesis and expression of vascular endothelial growth factor in endothelial cells

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Angiopoietin-1 inhibits endothelial cell apoptosis via the Akt/survivin pathway

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The survivin-like C. elegans BIR-1 protein acts with the Aurora-like kinase AIR-2 to affect chromosomes and the spindle midzone

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Vascular endothelial growth factor regulates endothelial cell survival through the phosphatidylinositol 3'-kinase/Akt signal transduction pathway. Requirement for Flk-1/KDR activation

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Angiopoietin-1 induces endothelial cell sprouting through the activation of focal adhesion kinase and plasmin secretion

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7 January 2021

The Tek/Tie2 receptor signals through a novel Dok-related docking protein, Dok-R

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7 January 2021

HCPTPA, a protein tyrosine phosphatase that regulates vascular endothelial growth factor receptor-mediated signal transduction and biological activity.

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7 January 2021

Functional interaction of vascular endothelial-protein-tyrosine phosphatase with the angiopoietin receptor Tie-2

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7 January 2021

Structure of the Tie2 RTK domain: self-inhibition by the nucleotide binding loop, activation loop, and C-terminal tail

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7 January 2021

Tie-1 receptor tyrosine kinase endodomain interaction with SHP2: potential signalling mechanisms and roles in angiogenesis

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Evidence for heterotypic interaction between the receptor tyrosine kinases TIE-1 and TIE-2.

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7 January 2021

Angiopoietin-1 protects the adult vasculature against plasma leakage.

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A novel endothelial cell surface receptor tyrosine kinase with extracellular epidermal growth factor homology domains

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VEGF couples hypertrophic cartilage remodeling, ossification and angiogenesis during endochondral bone formation

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Vascular endothelial growth factor is essential for corpus luteum angiogenesis.

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7 January 2021

Upregulated expression of vascular endothelial growth factor in proliferative diabetic retinopathy

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7 January 2021

Molecular cloning and characterization of mouse TIE and TEK receptor tyrosine kinase genes and their expression in hematopoietic stem cells

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7 January 2021

Critical role of the TIE2 endothelial cell receptor in the development of definitive hematopoiesis

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7 January 2021

A role for hematopoietic stem cells in promoting angiogenesis

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Targeted deficiency or cytosolic truncation of the VE-cadherin gene in mice impairs VEGF-mediated endothelial survival and angiogenesis

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Identification of a human VPF/VEGF 3' untranslated region mediating hypoxia-induced mRNA stability

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Abnormal angiogenesis and responses to glucose and oxygen deprivation in mice lacking the protein ARNT.

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HIF-1 alpha is required for solid tumor formation and embryonic vascularization.

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The transcription factor EPAS-1/hypoxia-inducible factor 2alpha plays an important role in vascular remodeling

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Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis

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The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

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The von Hippel-Lindau tumor suppressor protein is a component of an E3 ubiquitin-protein ligase activity

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Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours

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7 January 2021

Angiopoietin-1 and -2 coiled coil domains mediate distinct homo-oligomerization patterns, but fibrinogen-like domains mediate ligand activity

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7 January 2021

Characterization and expression of a novel alternatively spliced human angiopoietin-2

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7 January 2021

Characterization of a novel form of angiopoietin-2 (Ang-2B) and expression of VEGF and angiopoietin-2 during chicken testicular development and regression.

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7 January 2021

Recruitment of Dok-R to the EGF receptor through its PTB domain is required for attenuation of Erk MAP kinase activation

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Identifiers

DOI

10.1038/35067005

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Dimensions Publication ID

31 July 2017

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