FGF and VEGF function in angiogenesis: signalling pathways, biological responses and therapeutic inhibition (Q34204938)

31 July 2017

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title

FGF and VEGF function in angiogenesis: signalling pathways, biological responses and therapeutic inhibition (English)

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31 July 2017

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Cross MJ

1

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PubMed ID

11282421

31 July 2017

Claesson-Welsh L

series ordinal

2

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31 July 2017

1 April 2001

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Trends in Pharmacological Sciences

31 July 2017

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31 July 2017

22

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31 July 2017

201-207

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31 July 2017

4

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Mechanisms of angiogenesis and arteriogenesis

31 July 2017

1 reference

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Vascular-specific growth factors and blood vessel formation

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Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis

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7 January 2021

Tumor angiogenesis: past, present and the near future

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7 January 2021

Heparin Affinity: Purification of a Tumor-Derived Capillary Endothelial Cell Growth Factor

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Fibroblast growth factor 2: its structure and property, paracrine function, tumor angiogenesis, and prostate-related mitogenic and oncogenic functions

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7 January 2021

Extracellular sequestration and release of fibroblast growth factor: a regulatory mechanism?

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7 January 2021

FGFs, heparan sulfate and FGFRs: complex interactions essential for development

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7 January 2021

Fibroblast growth factor receptor tyrosine kinases: molecular analysis and signal transduction

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7 January 2021

Structural and Functional Diversity in the FGf Receptor Multigene Family

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7 January 2021

Fibroblast growth factors as multifunctional signaling factors

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7 January 2021

Murine FGFR-1 is required for early postimplantation growth and axial organization

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7 January 2021

Maintenance of vascular integrity in the embryo requires signaling through the fibroblast growth factor receptor

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7 January 2021

Impaired cerebral cortex development and blood pressure regulation in FGF-2-deficient mice

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7 January 2021

Skeletal overgrowth and deafness in mice lacking fibroblast growth factor receptor 3.

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7 January 2021

Structural basis for FGF receptor dimerization and activation

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7 January 2021

Signal transduction by fibroblast growth factor receptors

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7 January 2021

Fibroblast growth factor receptor-1-mediated endothelial cell proliferation is dependent on the Src homology (SH) 2/SH3 domain-containing adaptor protein Crk

1 reference

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7 January 2021

A tyrosine-phosphorylated carboxy-terminal peptide of the fibroblast growth factor receptor (Flg) is a binding site for the SH2 domain of phospholipase C-gamma 1

1 reference

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7 January 2021

Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid

1 reference

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7 January 2021

Purification and characterization of a naturally occurring vascular endothelial growth factor.placenta growth factor heterodimer

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7 January 2021

Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis

1 reference

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7 January 2021

Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele

1 reference

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7 January 2021

Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene

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7 January 2021

Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium

1 reference

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7 January 2021

Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice

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7 January 2021

Flt-1 lacking the tyrosine kinase domain is sufficient for normal development and angiogenesis in mice

1 reference

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7 January 2021

Increased gene expression for VEGF and the VEGF receptors KDR/Flk and Flt in lungs exposed to acute or to chronic hypoxia. Modulation of gene expression by nitric oxide

1 reference

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7 January 2021

Differential transcriptional regulation of the two vascular endothelial growth factor receptor genes. Flt-1, but not Flk-1/KDR, is up-regulated by hypoxia.

1 reference

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7 January 2021

Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor

1 reference

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7 January 2021

Biological activity and phosphorylation sites of the bacterially expressed cytosolic domain of the KDR VEGF-receptor

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7 January 2021

Role of alphavbeta3 integrin in the activation of vascular endothelial growth factor receptor-2.

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7 January 2021

The Vascular Endothelial Growth Factor Receptor Flt-1 Mediates Biological Activities

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7 January 2021

Integrin alphavbeta3 requirement for sustained mitogen-activated protein kinase activity during angiogenesis

1 reference

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7 January 2021

Selective requirement for Src kinases during VEGF-induced angiogenesis and vascular permeability

1 reference

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7 January 2021

Phosphatidylinositol 3-kinase signaling mediates angiogenesis and expression of vascular endothelial growth factor in endothelial cells

1 reference

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7 January 2021

Vascular system defects and neuronal apoptosis in mice lacking ras GTPase-activating protein

1 reference

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7 January 2021

Endothelial apoptosis in Braf-deficient mice

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7 January 2021

Mekk3 is essential for early embryonic cardiovascular development

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7 January 2021

Current status of antiangiogenic factors

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7 January 2021

Antiangiogenic strategies and agents in clinical trials

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7 January 2021

Angiogenesis: new insights and therapeutic potential

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7 January 2021

Left ventricular electromechanical mapping to assess efficacy of phVEGF(165) gene transfer for therapeutic angiogenesis in chronic myocardial ischemia

1 reference

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7 January 2021

Genes expressed in human tumor endothelium

1 reference

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7 January 2021

Fibroblast growth factor receptor-1 mediates chemotaxis independently of direct SH2-domain protein binding.

1 reference

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7 January 2021

Novel recognition motif on fibroblast growth factor receptor mediates direct association and activation of SNT adapter proteins

1 reference

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7 January 2021

A lipid-anchored Grb2-binding protein that links FGF-receptor activation to the Ras/MAPK signaling pathway

1 reference

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7 January 2021

Binding of Shp2 tyrosine phosphatase to FRS2 is essential for fibroblast growth factor-induced PC12 cell differentiation

1 reference

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7 January 2021

Contribution of Src and Ras pathways in FGF-2 induced endothelial cell differentiation

1 reference

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7 January 2021

Association of fibroblast growth factor receptor 1 with the adaptor protein Grb14. Characterization of a new receptor binding partner

1 reference

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7 January 2021

Phosphatidylinositol 3'-kinase-independent p70 S6 kinase activation by fibroblast growth factor receptor-1 is important for proliferation but not differentiation of endothelial cells.

1 reference

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7 January 2021

p38 mitogen-activated protein kinase activation is required for fibroblast growth factor-2-stimulated cell proliferation but not differentiation

1 reference

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7 January 2021

The 230 kDa mature form of KDR/Flk-1 (VEGF receptor-2) activates the PLC-gamma pathway and partially induces mitotic signals in NIH3T3 fibroblasts

1 reference

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7 January 2021

Interactions of FLT-1 and KDR with phospholipase C gamma: identification of the phosphotyrosine binding sites

1 reference

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7 January 2021

VRAP is an adaptor protein that binds KDR, a receptor for vascular endothelial cell growth factor

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901676-X

7 January 2021

1 reference

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7 January 2021

Vascular endothelial growth factor stimulates prostacyclin production and activation of cytosolic phospholipase A2 in endothelial cells via p42/p44 mitogen-activated protein kinase

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https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901676-X

7 January 2021

Vascular endothelial growth factor/vascular permeability factor enhances vascular permeability via nitric oxide and prostacyclin

1 reference

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7 January 2021

Roles of two VEGF receptors, Flt-1 and KDR, in the signal transduction of VEGF effects in human vascular endothelial cells

1 reference

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7 January 2021

Utilization of distinct signaling pathways by receptors for vascular endothelial cell growth factor and other mitogens in the induction of endothelial cell proliferation

1 reference

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7 January 2021

Vascular endothelial growth factor regulates endothelial cell survival through the phosphatidylinositol 3'-kinase/Akt signal transduction pathway. Requirement for Flk-1/KDR activation

1 reference

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7 January 2021

Regulation of endothelium-derived nitric oxide production by the protein kinase Akt

1 reference

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7 January 2021

Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation

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7 January 2021

Phosphorylation of the endothelial nitric oxide synthase at ser-1177 is required for VEGF-induced endothelial cell migration

1 reference

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7 January 2021

Vascular endothelial growth factor signals endothelial cell production of nitric oxide and prostacyclin through flk-1/KDR activation of c-Src

1 reference

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7 January 2021

Vascular endothelial growth factor (VEGF)-driven actin-based motility is mediated by VEGFR2 and requires concerted activation of stress-activated protein kinase 2 (SAPK2/p38) and geldanamycin-sensitive phosphorylation of focal adhesion kinase

1 reference

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7 January 2021

Vascular endothelial growth factor stimulates tyrosine phosphorylation and recruitment to new focal adhesions of focal adhesion kinase and paxillin in endothelial cells

1 reference

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7 January 2021

Nitric oxide is an upstream signal of vascular endothelial growth factor-induced extracellular signal-regulated kinase1/2 activation in postcapillary endothelium

1 reference

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7 January 2021

Protein kinase G mediates vascular endothelial growth factor-induced Raf-1 activation and proliferation in human endothelial cells

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7 January 2021

VEGF receptor signaling in tumor angiogenesis

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7 January 2021

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Identifiers

DOI

1 reference

31 July 2017

1 reference

PubMed ID

11282421