Flt-1 lacking the tyrosine kinase domain is sufficient for normal development and angiogenesis in mice (Q28504776)

24 January 2017

title

Flt-1 lacking the tyrosine kinase domain is sufficient for normal development and angiogenesis in mice (English)

1 reference

FMS-like tyrosine kinase 1

24 January 2017

main subject

1 reference

GOA release 2020-03-11

1 reference

S. Hiratsuka

1

1 reference

24 January 2017

O. Minowa

2

1 reference

24 January 2017

J. Kuno

3

1 reference

24 January 2017

T. Noda

4

1 reference

24 January 2017

M. Shibuya

5

1 reference

24 January 2017

publication date

4 August 1998

1 reference

https://europepmc.org/articles/pmc21341?pdf=render

24 January 2017

language of work or name

English

0 references

work available at URL

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A9689083

https://europepmc.org/articles/PMC21341

3 January 2025

file format

HyperText Markup Language

online access status

open access

content deliverer

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A9689083

https://europepmc.org/articles/PMC21341?pdf=render

3 January 2025

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A9689083

https://pnas.org/doi/pdf/10.1073/pnas.95.16.9349

3 January 2025

1 reference

Crossref

DOI

10.1073/PNAS.95.16.9349

https://api.crossref.org/works/10.1073/PNAS.95.16.9349

Proceedings of the National Academy of Sciences of the United States of America

3 January 2025

published in

1 reference

24 January 2017

volume

95

1 reference

24 January 2017

issue

16

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24 January 2017

page(s)

9349–9354

1 reference

The Phosphorylated 1169-Tyrosine Containing Region of Flt-1 Kinase (VEGFR-1) Is a Major Binding Site for PLCγ

24 January 2017

cites work

1 reference

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The 230 kDa mature form of KDR/Flk-1 (VEGF receptor-2) activates the PLC-gamma pathway and partially induces mitotic signals in NIH3T3 fibroblasts

19 March 2017

1 reference

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Uncoupling of Grb2 from the Met receptor in vivo reveals complex roles in muscle development

19 March 2017

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Nuk controls pathfinding of commissural axons in the mammalian central nervous system

19 March 2017

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The receptor tyrosine kinase MuSK is required for neuromuscular junction formation in vivo

19 March 2017

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Migration of human monocytes in response to vascular endothelial growth factor (VEGF) is mediated via the VEGF receptor flt-1

19 March 2017

1 reference

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Fetal liver kinase 1 is a receptor for vascular endothelial growth factor and is selectively expressed in vascular endothelium

19 March 2017

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Inhibition of vascular endothelial cell growth factor activity by an endogenously encoded soluble receptor

19 March 2017

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Disruption of the neurotrophin-3 receptor gene trkC eliminates la muscle afferents and results in abnormal movements

19 March 2017

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A new communication system between hepatocytes and sinusoidal endothelial cells in liver through vascular endothelial growth factor and Flt tyrosine kinase receptor family (Flt-1 and KDR/Flk-1)

19 March 2017

1 reference

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Different signal transduction properties of KDR and Flt1, two receptors for vascular endothelial growth factor

19 March 2017

1 reference

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Placenta growth factor. Potentiation of vascular endothelial growth factor bioactivity, in vitro and in vivo, and high affinity binding to Flt-1 but not to Flk-1/KDR

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=21341

A unique signal transduction from FLT tyrosine kinase, a receptor for vascular endothelial growth factor VEGF

19 March 2017

1 reference

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Phospholipase C-gamma 1 and phosphatidylinositol 3 kinase are the downstream mediators of the PDGF receptor's mitogenic signal

19 March 2017

1 reference

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Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium

19 March 2017

1 reference

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Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=21341

Nucleotide sequence and expression of a novel human receptor-type tyrosine kinase gene (flt) closely related to the fms family

19 March 2017

1 reference

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Isolation of a human placenta cDNA coding for a protein related to the vascular permeability factor

19 March 2017

1 reference

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Targeted mutation of the DNA methyltransferase gene results in embryonic lethality

19 March 2017

1 reference

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Identification of the KDR tyrosine kinase as a receptor for vascular endothelial cell growth factor

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=21341

Distinct phosphotyrosines on a growth factor receptor bind to specific molecules that mediate different signaling pathways

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=21341

Mechanisms of angiogenesis

19 March 2017

1 reference

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Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene

7 April 2017

1 reference

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Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele

7 April 2017

1 reference

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The biology of vascular endothelial growth factor

7 April 2017

1 reference

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Growth factor signaling by receptor tyrosine kinases

7 April 2017

1 reference

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Genomic organization of the flt-1 gene encoding for Vascular Endothelial Growth Factor (VEGF) Receptor-1 suggests an intimate evolutionary relationship between the 7-Ig and the 5-Ig tyrosine kinase receptors

7 April 2017

1 reference

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Characterization of the Extracellular Domain in Vascular Endothelial Growth Factor Receptor‐1 (Flt‐1 Tyrosine Kinase)

29 September 2017

1 reference

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Mapping of the sites for ligand binding and receptor dimerization at the extracellular domain of the vascular endothelial growth factor receptor FLT-1.

29 September 2017

1 reference

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Role of VEGF-flt receptor system in normal and tumor angiogenesis.

29 September 2017

1 reference

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Ataxia and epileptic seizures in mice lacking type 1 inositol 1,4,5-trisphosphate receptor.

29 September 2017

1 reference

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Endothelial receptor tyrosine kinases involved in angiogenesis.

29 September 2017

1 reference

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Binding sites for vascular endothelial growth factor are localized on endothelial cells in adult rat tissues

29 September 2017

1 reference

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A receptor tyrosine kinase cDNA isolated from a population of enriched primitive hematopoietic cells and exhibiting close genetic linkage to c-kit

29 September 2017

1 reference

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Absence of Sensory Neurons before Target Innervation in Brain-Derived Neurotrophic Factor-, Neurotrophin 3-, and TrkC-Deficient Embryonic Mice

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=21341

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=21341

Molecular cloning of murine FLT and FLT4.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=21341

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=21341

Vascular endothelial cell growth factor promotes tyrosine phosphorylation of mediators of signal transduction that contain SH2 domains. Association with endothelial cell proliferation

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=21341

Flt-1 but not KDR/Flk-1 tyrosine kinase is a receptor for placenta growth factor, which is related to vascular endothelial growth factor.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=21341

Enhanced vascular permeability and haemorrhage-inducing activity of rabbit C5ades arg: probable role of polymorphonuclear leucocyte lysosomes

27 November 2018

1 reference

12 December 2020

Two molecules related to the VEGF receptor are expressed in early endothelial cells during avian embryonic development

1 reference

12 December 2020

Specificity of vascular endothelial cell growth factor receptor ligand binding domains

1 reference

12 December 2020

The Vascular Endothelial Growth Factor Receptor Flt-1 Mediates Biological Activities

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.95.16.9349

1 reference

ADS bibcode

1998PNAS...95.9349H

0 references

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