Inhibition of cyclin-dependent kinase 2 by p21 is necessary for retinoblastoma protein-mediated G1 arrest after gamma-irradiation (Q34946238)

5 August 2017

title

Inhibition of cyclin-dependent kinase 2 by p21 is necessary for retinoblastoma protein-mediated G1 arrest after gamma-irradiation (English)

1 reference

5 August 2017

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J Brugarolas

1

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5 August 2017

K Moberg

2

1 reference

5 August 2017

S D Boyd

3

1 reference

5 August 2017

Y Taya

4

1 reference

5 August 2017

T Jacks

5

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5 August 2017

J A Lees

6

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5 August 2017

publication date

1 February 1999

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Proceedings of the National Academy of Sciences of the United States of America

5 August 2017

language of work or name

English

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published in

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5 August 2017

volume

96

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5 August 2017

issue

3

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5 August 2017

page(s)

1002-1007

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pRB plays an essential role in cell cycle arrest induced by DNA damage

5 August 2017

cites work

1 reference

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p21 Is a Critical CDK2 Regulator Essential for Proliferation Control in Rb-deficient Cells

8 July 2018

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Functional Inactivation of the Retinoblastoma Protein Requires Sequential Modification by at Least Two Distinct Cyclin-cdk Complexes

8 July 2018

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Hypo-phosphorylation of the retinoblastoma protein (pRb) by cyclin D:Cdk4/6 complexes results in active pRb

8 July 2018

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Role of the Rb/E2F pathway in cell growth control

8 July 2018

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The human papillomavirus E7 oncoprotein can uncouple cellular differentiation and proliferation in human keratinocytes by abrogating p21Cip1-mediated inhibition of cdk2.

8 July 2018

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Inhibition of CDK activity and PCNA-dependent DNA replication by p21 is blocked by interaction with the HPV-16 E7 oncoprotein

8 July 2018

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Cyclin D1/Cdk4 regulates retinoblastoma protein-mediated cell cycle arrest by site-specific phosphorylation

8 July 2018

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8 July 2018

When checkpoints fail

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The consensus motif for phosphorylation by cyclin D1-Cdk4 is different from that for phosphorylation by cyclin A/E-Cdk2

8 July 2018

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Cyclin-dependent kinases are inactivated by a combination of p21 and Thr-14/Tyr-15 phosphorylation after UV-induced DNA damage

8 July 2018

1 reference

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UVB radiation induces p21Cip1/WAF1 and mediates G1 and S phase checkpoints.

8 July 2018

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p53-dependent apoptosis modulates the cytotoxicity of anticancer agents

8 July 2018

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Functional interactions of the retinoblastoma protein with mammalian D-type cyclins

8 July 2018

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Inhibition of CDK2 activity in vivo by an associated 20K regulatory subunit.

8 July 2018

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p21 is a universal inhibitor of cyclin kinases

8 July 2018

1 reference

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WAF1, a potential mediator of p53 tumor suppression

8 July 2018

1 reference

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The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=15340

p53-dependent G1 arrest involves pRB-related proteins and is disrupted by the human papillomavirus 16 E7 oncoprotein

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=15340

Identification of G1 kinase activity for cdk6, a novel cyclin D partner

8 July 2018

1 reference

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D-type cyclin-dependent kinase activity in mammalian cells

8 July 2018

1 reference

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Deficiency of retinoblastoma protein leads to inappropriate S-phase entry, activation of E2F-responsive genes, and apoptosis.

8 July 2018

1 reference

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Direct transcriptional repression by pRB and its reversal by specific cyclins

8 July 2018

1 reference

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Human cyclin E, a nuclear protein essential for the G1-to-S phase transition

8 July 2018

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Cyclin D1 is dispensable for G1 control in retinoblastoma gene-deficient cells independently of cdk4 activity.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=15340

Mice Lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=15340

Requirement for tyrosine phosphorylation of Cdk4 in Gl arrest induced by ultraviolet irradiation

8 July 2018

1 reference

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Mechanism of active transcriptional repression by the retinoblastoma protein

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=15340

p21 is necessary for the p53-mediated G1 arrest in human cancer cells

8 July 2018

1 reference

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Radiation-induced cell cycle arrest compromised by p21 deficiency

8 July 2018

1 reference

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Participation of p53 protein in the cellular response to DNA damage

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=15340

The retinoblastoma protein is phosphorylated on multiple sites by human cdc2

8 July 2018

1 reference

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The retinoblastoma gene and gene product

8 July 2018

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Cancer. p53, guardian of the genome

8 July 2018

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A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

8 July 2018

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Regulation of retinoblastoma protein functions by ectopic expression of human cyclins

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=15340

Adenovirus E1A targets key regulators of cell proliferation

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=15340

Retinoblastoma protein switches the E2F site from positive to negative element

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=15340

p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest.

8 July 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.96.3.1002

Inhibition of ras-induced proliferation and cellular transformation by p16INK4.

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.96.3.1002

Retinoblastoma-protein-dependent cell-cycle inhibition by the tumour suppressor p16

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.96.3.1002

Differential phosphorylation of the retinoblastoma protein by G1/S cyclin-dependent kinases

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/9927683

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.96.3.1002

1 reference

release_uut435oqurhqtjhqzf7liammci

5 August 2017

0 references

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/uut435oqurhqtjhqzf7liammci

mapped directly with Wikidata item

24 November 2022

based on heuristic

PMC publication ID

15340

1 reference

5 August 2017

1 reference