Gamma-synuclein promotes cancer cell survival and inhibits stress- and chemotherapy drug-induced apoptosis by modulating MAPK pathways (Q34139335)

31 July 2017

Gamma-synuclein promotes cancer cell survival and inhibits stress- and chemotherapy drug-induced apoptosis by modulating MAPK pathways (English)

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31 July 2017

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Zhong-Zong Pan

1

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31 July 2017

Wendy Bruening

2

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31 July 2017

Benoit I Giasson

3

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31 July 2017

Virginia M-Y Lee

4

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31 July 2017

Andrew K Godwin

5

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31 July 2017

language of work or name

English

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publication date

16 July 2002

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Journal of Biological Chemistry

31 July 2017

11

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based on heuristic

inferred from page(s)

published in

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31 July 2017

277

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31 July 2017

35050-35060

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31 July 2017

38

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31 July 2017

Cancer statistics, 1999.

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https://api.crossref.org/works/10.1074%2FJBC.M201650200

21 January 2018

Cancer statistics, 2000.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201650200

Synucleins are expressed in the majority of breast and ovarian carcinomas and in preneoplastic lesions of the ovary

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201650200

Transcriptional suppression of synuclein gamma (SNCG) expression in human breast cancer cells by the growth inhibitory cytokine oncostatin M.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M201650200

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M201650200

Synoretin--A new protein belonging to the synuclein family

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201650200

The synucleins: a family of proteins involved in synaptic function, plasticity, neurodegeneration and disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201650200

Cellular co-localization of phosphorylated tau- and NACP/alpha-synuclein-epitopes in lewy bodies in sporadic Parkinson's disease and in dementia with Lewy bodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201650200

Glial cytoplasmic inclusions in white matter oligodendrocytes of multiple system atrophy brains contain insoluble alpha-synuclein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201650200

Lewy body in neurodegeneration with brain iron accumulation type 1 is immunoreactive for alpha-synuclein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201650200

Immunoelectron-microscopic demonstration of NACP/alpha-synuclein-epitopes on the filamentous component of Lewy bodies in Parkinson's disease and in dementia with Lewy bodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201650200

Nigral and cortical Lewy bodies and dystrophic nigral neurites in Parkinson's disease and cortical Lewy body disease contain alpha-synuclein immunoreactivity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201650200

alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with lewy bodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201650200

14-3-3 proteins: structure, function, and regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201650200

Interaction of 14-3-3 with signaling proteins is mediated by the recognition of phosphoserine

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201650200

Phosphoserine/threonine-binding domains

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M201650200

The structural basis for 14-3-3:phosphopeptide binding specificity

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M201650200

A dimeric 14-3-3 protein is an essential cofactor for Raf kinase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201650200

Chaperone-like activity of synucleins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201650200

Prominent perikaryal expression of alpha- and beta-synuclein in neurons of dorsal root ganglion and in medullary neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201650200

alpha-Synuclein forms a complex with transcription factor Elk-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201650200

alpha-Synuclein affects the MAPK pathway and accelerates cell death

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M201650200

Signal transduction by the JNK group of MAP kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201650200

Ultraviolet light and osmotic stress: activation of the JNK cascade through multiple growth factor and cytokine receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201650200

Contribution of phosphatidylinositol 3-kinase to radiation resistance in human melanoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201650200

Mitogen- and stress-activated protein kinase 1 mediates activation of Akt by ultraviolet B irradiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201650200

Microtubule dysfunction induced by paclitaxel initiates apoptosis through both c-Jun N-terminal kinase (JNK)-dependent and -independent pathways in ovarian cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201650200

Role of the stress-activated/c-Jun NH2-terminal protein kinase pathway in the cellular response to adriamycin and other chemotherapeutic drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201650200

Microtubule inhibitors elicit differential effects on MAP kinase (JNK, ERK, and p38) signaling pathways in human KB-3 carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201650200

Etoposide-induced activation of c-jun N-terminal kinase (JNK) correlates with drug-induced apoptosis in salivary gland acinar cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201650200

Differential involvement of MEK kinase 1 (MEKK1) in the induction of apoptosis in response to microtubule-targeted drugs versus DNA damaging agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201650200

Synucleinopathies: clinical and pathological implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201650200

Parkinson's disease-associated alpha-synuclein is more fibrillogenic than beta- and gamma-synuclein and cannot cross-seed its homologs

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201650200

Molecular mechanisms for aberrant expression of the human breast cancer specific gene 1 in breast cancer cells: control of transcription by DNA methylation and intronic sequences

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201650200

Intraneuronal filamentous tau protein and alpha-synuclein deposits in neurodegenerative diseases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201650200

Aggregation of neurofilament and alpha-synuclein proteins in Lewy bodies: implications for the pathogenesis of Parkinson disease and Lewy body dementia

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201650200

Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201650200

Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201650200

Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201650200

The prognostic significance of p53 tumor suppressor gene alterations in ovarian carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201650200

NF-kappa B activation by ultraviolet light not dependent on a nuclear signal.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201650200

Paclitaxel-induced cell death: where the cell cycle and apoptosis come together

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201650200

Effect of the overexpression of wild-type or mutant alpha-synuclein on cell susceptibility to insult

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201650200

Inducible expression of mutant alpha-synuclein decreases proteasome activity and increases sensitivity to mitochondria-dependent apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201650200

Overexpression of human alpha-synuclein causes dopamine neuron death in rat primary culture and immortalized mesencephalon-derived cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201650200

Expression of mutant alpha-synuclein causes increased susceptibility to dopamine toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201650200

Wild-type but not Parkinson's disease-related ala-53 --> Thr mutant alpha -synuclein protects neuronal cells from apoptotic stimuli

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201650200

Frontotemporal dementia: neuropil spheroids and presynaptic terminal degeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201650200

alpha-synuclein promotes mitochondrial deficit and oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201650200

TP53 mutations and abnormal p53 protein staining in breast carcinomas related to prognosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201650200

Induction of neuronal death by α-synuclein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201650200

Paclitaxel (Taxol)-induced gene expression and cell death are both mediated by the activation of c-Jun NH2-terminal kinase (JNK/SAPK)

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201650200

Vinblastine-induced phosphorylation of Bcl-2 and Bcl-XL is mediated by JNK and occurs in parallel with inactivation of the Raf-1/MEK/ERK cascade

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201650200

The mammalian ultraviolet response is triggered by activation of src tyrosine kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M201650200

21 January 2018

Identifiers

DOI

10.1074/JBC.M201650200

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31 July 2017

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