"The quest for biomarkers": are we on the right technical track? (Q34116103)

31 July 2017

"The quest for biomarkers": are we on the right technical track? (English)

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31 July 2017

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Egisto Boschetti

1

1 reference

PubMed ID

22213582

31 July 2017

Maxey C M Chung

series ordinal

2

1 reference

PubMed ID

22213582

31 July 2017

Pier Giorgio Righetti

series ordinal

3

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31 July 2017

27 December 2011

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Proteomics - Clinical Applications

31 July 2017

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31 July 2017

6

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31 July 2017

22-41

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31 July 2017

1-2

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Strategies for discovering novel cancer biomarkers through utilization of emerging technologies

31 July 2017

1 reference

https://api.crossref.org/works/10.1002%2FPRCA.201100039

Proteomics technologies for the global identification and quantification of proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPRCA.201100039

Serum protein markers for early detection of ovarian cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPRCA.201100039

Evaluation of apolipoprotein A1 and posttranslationally modified forms of transthyretin as biomarkers for ovarian cancer detection in an independent study population.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPRCA.201100039

Characterization of serum biomarkers for detection of early stage ovarian cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPRCA.201100039

Identification of platinum-resistance associated proteins through proteomic analysis of human ovarian cancer cells and their platinum-resistant sublines

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPRCA.201100039

Use of a single-chain antibody library for ovarian cancer biomarker discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPRCA.201100039

Functional proteomics of kallikrein-related peptidases in ovarian cancer ascites fluid

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPRCA.201100039

Identification of candidate biomarkers with cancer-specific glycosylation in the tissue and serum of endometrioid ovarian cancer patients by glycoproteomic analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPRCA.201100039

Identification of candidate biomarkers in ovarian cancer serum by depletion of highly abundant proteins and differential in-gel electrophoresis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPRCA.201100039

Combinatorial peptide libraries facilitate development of multiple reaction monitoring assays for low-abundance proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPRCA.201100039

Status of tumor markers in epithelial ovarian cancer has there been any progress? A review

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPRCA.201100039

Solid-phase hexapeptide ligand libraries open up new perspectives in the discovery of biomarkers in human plasma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPRCA.201100039

A recipe for proteomics diagnostic test development: the OVA1 test, from biomarker discovery to FDA clearance

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPRCA.201100039

Proteomic analysis of human cervico-vaginal fluid

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPRCA.201100039

Quantitative analysis of age specific variation in the abundance of human female parotid salivary proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPRCA.201100039

A pI-based protein fractionation method using solid-state buffers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPRCA.201100039

Proteomic identification of human serum biomarkers in diabetes mellitus type 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPRCA.201100039

Using immobilized metal affinity chromatography, two-dimensional electrophoresis and mass spectrometry to identify hepatocellular proteins with copper-binding ability

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPRCA.201100039

Twenty-five years of immobilized metal ion affinity chromatography: past, present and future

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPRCA.201100039

Proteomic profiling during atherosclerosis progression using SELDI-TOF-MS: effect of darbepoetin treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPRCA.201100039

Complex proteome prefractionation using microscale solution isoelectrofocusing

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPRCA.201100039

Application of free flow electrophoresis to the analysis of the urine proteome

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPRCA.201100039

Affinity prefractionation for MS-based plasma proteomics

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPRCA.201100039

Serum protein profiling by solid phase extraction and mass spectrometry: a future diagnostics tool?

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPRCA.201100039

A two step fractionation approach for plasma proteomics using immunodepletion of abundant proteins and multi-lectin affinity chromatography: Application to the analysis of obesity, diabetes, and hypertension diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPRCA.201100039

Lectin-based glycoproteomics to explore and analyze hepatocellular carcinoma-related glycoprotein markers

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPRCA.201100039

Glycosylation variants of mucins and CEACAMs as candidate biomarkers for the diagnosis of pancreatic cystic neoplasms

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPRCA.201100039

Protein carbonylation in human diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPRCA.201100039

Plasma homocysteine and markers for oxidative stress and inflammation in patients with coronary artery disease--a prospective randomized study of vitamin supplementation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPRCA.201100039

Oxidative stress and transcriptional regulation in Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPRCA.201100039

An altered pattern of liver apolipoprotein A-I isoforms is implicated in male chronic hepatitis B progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPRCA.201100039

Pathway-based identification of biomarkers for targeted therapeutics: personalized oncology with PI3K pathway inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPRCA.201100039

Heparin chromatography to deplete high-abundance proteins for serum proteomics

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPRCA.201100039

Proteomic expression analysis of surgical human colorectal cancer tissues: up-regulation of PSB7, PRDX1, and SRP9 and hypoxic adaptation in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPRCA.201100039

Enrichment of human brain proteins by heparin chromatography

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPRCA.201100039

An approach to remove albumin for the proteomic analysis of low abundance biomarkers in human serum.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPRCA.201100039

Analysis of human serum by liquid chromatography-mass spectrometry: improved sample preparation and data analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPRCA.201100039

Multi-component immunoaffinity subtraction chromatography: an innovative step towards a comprehensive survey of the human plasma proteome

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPRCA.201100039

Immunoaffinity separation of plasma proteins by IgY microbeads: meeting the needs of proteomic sample preparation and analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPRCA.201100039

Deep depletion of abundant serum proteins reveals low-abundant proteins as potential biomarkers for human ovarian cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPRCA.201100039

Quality control of serum albumin depletion for proteomic analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPRCA.201100039

Depletion of abundant plasma proteins and limitations of plasma proteomics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPRCA.201100039

2D-DIGE as a strategy to identify serum markers for the progression of prostate cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPRCA.201100039

Optimizing a proteomics platform for urine biomarker discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPRCA.201100039

Semi-targeted plasma proteomics discovery workflow utilizing two-stage protein depletion and off-line LC-MALDI MS/MS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPRCA.201100039

The proteome buccaneers: how to unearth your treasure chest via combinatorial peptide ligand libraries

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPRCA.201100039

Proteomic biomarkers for overall and progression-free survival in ovarian cancer patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPRCA.201100039

Deep proteome profiling of sera from never-smoked lung cancer patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPRCA.201100039

Evaluation of the combination of bead technology with SELDI-TOF-MS and 2-D DIGE for detection of plasma proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPRCA.201100039

A proteomic approach for plasma biomarker discovery with iTRAQ labelling and OFFGEL fractionation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPRCA.201100039

Three new potential ovarian cancer biomarkers detected in human urine with equalizer bead technology

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPRCA.201100039

New pre-analytical approach for the deep proteome analysis of sera from pancreatitis and pancreas cancer patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPRCA.201100039

In-depth exploration of cerebrospinal fluid by combining peptide ligand library treatment and label-free protein quantification

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPRCA.201100039

Isoelectric focusing in immobilized pH gradients: Principle, methodology and some applications

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPRCA.201100039

Improvement of the solubilization of proteins in two-dimensional electrophoresis with immobilized pH gradients

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPRCA.201100039

All about DIGE: quantification technology for differential-display 2D-gel proteomics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPRCA.201100039

Difference gel electrophoresis: a single gel method for detecting changes in protein extracts

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPRCA.201100039

Discovery and validation of protein abundance differences between follicular thyroid neoplasms

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPRCA.201100039

Searching for serum tumor markers for colorectal cancer using a 2-D DIGE approach

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPRCA.201100039

Discovery and preclinical validation of salivary transcriptomic and proteomic biomarkers for the non-invasive detection of breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPRCA.201100039

Proteomic analysis identifies MMP-9, DJ-1 and A1BG as overexpressed proteins in pancreatic juice from pancreatic ductal adenocarcinoma patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPRCA.201100039

High-performance liquid chromatography/nano-electrospray ionization tandem mass spectrometry, two-dimensional difference in-gel electrophoresis and gene microarray identification of lymphatic metastasis-associated biomarkers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPRCA.201100039

Novel approaches to detect serum biomarkers for clinical response to interferon-beta treatment in multiple sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPRCA.201100039

The Lucid Proteomics System for top-down biomarker research

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPRCA.201100039

Identification of biomarkers for breast cancer in nipple aspiration and ductal lavage fluid

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPRCA.201100039

Identification of a novel panel of cerebrospinal fluid biomarkers for Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPRCA.201100039

Laser-capture microdissection and protein extraction for protein fingerprint of OSCC and OLK.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPRCA.201100039

A novel combinatorial approach to high-density peptide arrays

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPRCA.201100039

Glycoprotein analysis using protein microarrays and mass spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPRCA.201100039

A strategy for discovery of cancer glyco-biomarkers in serum using newly developed technologies for glycoproteomics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPRCA.201100039

High-content affinity-based proteomics: unlocking protein biomarker discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPRCA.201100039

Multidimensional glycan arrays for enhanced antibody profiling

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPRCA.201100039

Antibody-based microarrays

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPRCA.201100039

A genecentric Human Protein Atlas for expression profiles based on antibodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPRCA.201100039

Recent progress in urinary proteomics

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPRCA.201100039

Protein profiling in human sera for identification of potential lung cancer biomarkers using antibody microarray.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPRCA.201100039

High-density peptide arrays

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPRCA.201100039

Protein arrays as tools for serum autoantibody marker discovery in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPRCA.201100039

Discovery of antibody biomarkers using protein microarrays of tumor antigens cloned in high throughput

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPRCA.201100039

Identification of candidate IgG biomarkers for Alzheimer's disease via combinatorial library screening

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPRCA.201100039

Reverse phase protein microarrays advance to use in clinical trials

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPRCA.201100039

Stable isotope labeling by amino acids in cell culture, SILAC, as a simple and accurate approach to expression proteomics

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPRCA.201100039

Mass spectrometric-based approaches in quantitative proteomics

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPRCA.201100039

An automated multidimensional protein identification technology for shotgun proteomics

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPRCA.201100039

Shotgun proteomic analysis of cerebrospinal fluid using off-gel electrophoresis as the first-dimension separation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPRCA.201100039

Differences in shotgun protein expression profile between superficial bladder transitional cell carcinoma and normal urothelium

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPRCA.201100039

Salivary proteomics for oral cancer biomarker discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPRCA.201100039

Proteomic technologies for the discovery of type 1 diabetes biomarkers

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPRCA.201100039

Mass-spectrometry-based clinical proteomics--a review and prospective

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPRCA.201100039

Identification of molecularly defined Staphylococcus aureus strains using matrix-assisted laser desorption/ionization time of flight mass spectrometry and the Biotyper 2.0 database.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPRCA.201100039

MALDI-TOF mass spectrometry is a fast and reliable platform for identification and ecological studies of species from family Rhizobiaceae

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPRCA.201100039

Combination of abundant protein depletion and multi-lectin affinity chromatography (M-LAC) for plasma protein biomarker discovery.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPRCA.201100039

Reduction of the concentration difference of proteins in biological liquids using a library of combinatorial ligands

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPRCA.201100039

A mass spectrometry-based proteomic approach for identification of serine/threonine-phosphorylated proteins by enrichment with phospho-specific antibodies: identification of a novel protein, Frigg, as a protein kinase A substrate

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPRCA.201100039

Proteomic identification of carbonylated proteins and their oxidation sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPRCA.201100039

A new approach for the detection and identification of protein impurities using combinatorial solid phase ligand libraries

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPRCA.201100039

Improvements in proteomic metrics of low abundance proteins through proteome equalization using ProteoMiner prior to MudPIT.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPRCA.201100039

ProteoMiner™ and SELDI-TOF-MS: a robust and highly reproducible combination for biomarker discovery from whole blood serum

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPRCA.201100039

Evaluation of two different albumin depletion strategies for improved analysis of human CSF by SELDI-TOF-MS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPRCA.201100039

Enriched sera protein profiling for detection of non-small cell lung cancer biomarkers

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPRCA.201100039

Extensive analysis of the cytoplasmic proteome of human erythrocytes using the peptide ligand library technology and advanced mass spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPRCA.201100039

Enhanced detection of low abundance human plasma proteins using a tandem IgY12-SuperMix immunoaffinity separation strategy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPRCA.201100039

Global and targeted quantitative proteomics for biomarker discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPRCA.201100039

Antigen identification and characterization of lung cancer specific monoclonal antibodies produced by mAb proteomics

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPRCA.201100039

A comparative study of cancer proteins in the human protein-protein interaction network

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPRCA.201100039

Membrane Proteome Analysis of Microdissected Ovarian Tumor Tissues Using Capillary Isoelectric Focusing/Reversed-Phase Liquid Chromatography−Tandem MS

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPRCA.201100039

Comparison of proteomic biomarker panels in urine and serum for ovarian cancer diagnosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPRCA.201100039

Characterization of the human blood plasma proteome

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPRCA.201100039

21 January 2018

Identifiers

DOI

10.1002/PRCA.201100039

1 reference

31 July 2017

1 reference

PubMed ID

22213582