Pathway-based identification of biomarkers for targeted therapeutics: personalized oncology with PI3K pathway inhibitors (Q39671200)

13 September 2017

Pathway-based identification of biomarkers for targeted therapeutics: personalized oncology with PI3K pathway inhibitors (English)

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13 September 2017

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Jannik N Andersen

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13 September 2017

Sriram Sathyanarayanan

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13 September 2017

Alessandra Di Bacco

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13 September 2017

An Chi

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13 September 2017

Theresa Zhang

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13 September 2017

Albert H Chen

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13 September 2017

Brian Dolinski

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13 September 2017

Manfred Kraus

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13 September 2017

Brian Roberts

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13 September 2017

William Arthur

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13 September 2017

Rich A Klinghoffer

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13 September 2017

Diana Gargano

12

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13 September 2017

Lixia Li

13

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13 September 2017

Igor Feldman

14

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Bethany Lynch

15

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13 September 2017

John Rush

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13 September 2017

Ronald C Hendrickson

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13 September 2017

Peter Blume-Jensen

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13 September 2017

Cloud P Paweletz

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13 September 2017

language of work or name

English

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publication date

1 August 2010

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Science Translational Medicine

13 September 2017

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13 September 2017

2

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43ra55

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43

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Oncogenic kinase signalling

13 September 2017

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Cancer genes and the pathways they control

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The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism

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A complex interplay between Akt, TSC2 and the two mTOR complexes

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Cancer. Addiction to oncogenes--the Achilles heal of cancer

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Principles of cancer therapy: oncogene and non-oncogene addiction

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Biomarker-driven early clinical trials in oncology: a paradigm shift in drug development

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PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer

21 January 2018

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High frequency of mutations of the PIK3CA gene in human cancers

21 January 2018

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Targeting PI3K signalling in cancer: opportunities, challenges and limitations

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Crystal structure and functional analysis of Ras binding to its effector phosphoinositide 3-kinase gamma

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Loss of PTEN/MMAC1/TEP in EGF receptor-expressing tumor cells counteracts the antitumor action of EGFR tyrosine kinase inhibitors

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Molecular determinants of the response of glioblastomas to EGFR kinase inhibitors.

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A functional genetic approach identifies the PI3K pathway as a major determinant of trastuzumab resistance in breast cancer

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mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt

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Poor prognosis in carcinoma is associated with a gene expression signature of aberrant PTEN tumor suppressor pathway activity.

21 January 2018

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Molecular basis for the substrate specificity of protein kinase B; comparison with MAPKAP kinase-1 and p70 S6 kinase

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A structural basis for substrate specificities of protein Ser/Thr kinases: primary sequence preference of casein kinases I and II, NIMA, phosphorylase kinase, calmodulin-dependent kinase II, CDK5, and Erk1.

21 January 2018

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A predictive scale for evaluating cyclin-dependent kinase substrates. A comparison of p34cdc2 and p33cdk2.

21 January 2018

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The nuts and bolts of AGC protein kinases

21 January 2018

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The hallmark of AGC kinase functional divergence is its C-terminal tail, a cis-acting regulatory module

21 January 2018

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Signaling networks assembled by oncogenic EGFR and c-Met

21 January 2018

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The SCX/IMAC enrichment approach for global phosphorylation analysis by mass spectrometry

21 January 2018

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Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry

21 January 2018

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Large-scale characterization of HeLa cell nuclear phosphoproteins

21 January 2018

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Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis

21 January 2018

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Sensitive multiplexed analysis of kinase activities and activity-based kinase identification

21 January 2018

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Allosteric inhibitors of Akt1 and Akt2: a naphthyridinone with efficacy in an A2780 tumor xenograft model

21 January 2018

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Pharmacologic characterization of a potent inhibitor of class I phosphatidylinositide 3-kinases.

21 January 2018

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The role of 3-phosphoinositide-dependent protein kinase 1 in activating AGC kinases defined in embryonic stem cells

21 January 2018

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Development of high-throughput TR-FRET and AlphaScreen assays for identification of potent inhibitors of PDK1.

21 January 2018

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Reverse phase protein microarrays which capture disease progression show activation of pro-survival pathways at the cancer invasion front

21 January 2018

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Prostate-specific deletion of the murine Pten tumor suppressor gene leads to metastatic prostate cancer

21 January 2018

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Therapeutic strategies for inhibiting oncogenic BRAF signaling

21 January 2018

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Identification of filamin C as a new physiological substrate of PKBalpha using KESTREL

21 January 2018

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Ribosomal S6 kinase (RSK) regulates phosphorylation of filamin A on an important regulatory site

21 January 2018

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Filamin A, the Arp2/3 complex, and the morphology and function of cortical actin filaments in human melanoma cells

21 January 2018

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Mutational analysis of the tyrosine phosphatome in colorectal cancers

21 January 2018

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The protein tyrosine phosphatase Pez is a major phosphatase of adherens junctions and dephosphorylates beta-catenin

21 January 2018

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Reversal of stathmin-mediated resistance to paclitaxel and vinblastine in human breast carcinoma cells

21 January 2018

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Antitumor activity of rapamycin in a Phase I trial for patients with recurrent PTEN-deficient glioblastoma

21 January 2018

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Akt inhibitor A-443654 induces rapid Akt Ser-473 phosphorylation independent of mTORC1 inhibition

21 January 2018

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Immunoaffinity profiling of tyrosine phosphorylation in cancer cells

21 January 2018

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10.1126/SCITRANSLMED.3001065

21 January 2018

Identifiers

DOI

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13 September 2017

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