ADAMTS4 cleaves at the aggrecanase site (Glu373-Ala374) and secondarily at the matrix metalloproteinase site (Asn341-Phe342) in the aggrecan interglobular domain (Q34114956)

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English	ADAMTS4 cleaves at the aggrecanase site (Glu373-Ala374) and secondarily at the matrix metalloproteinase site (Asn341-Phe342) in the aggrecan interglobular domain	scientific article

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scholarly article

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Europe PubMed Central

31 July 2017

ADAMTS4 cleaves at the aggrecanase site (Glu373-Ala374) and secondarily at the matrix metalloproteinase site (Asn341-Phe342) in the aggrecan interglobular domain (English)

1 reference

Europe PubMed Central

31 July 2017

2

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Amanda J Fosang

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Europe PubMed Central

31 July 2017

author name string

Jennifer Westling

1

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Europe PubMed Central

31 July 2017

Karena Last

3

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Europe PubMed Central

31 July 2017

Vivian P Thompson

4

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Europe PubMed Central

31 July 2017

Kathy N Tomkinson

5

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Europe PubMed Central

31 July 2017

Tracy Hebert

6

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Europe PubMed Central

31 July 2017

Thomas McDonagh

7

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Europe PubMed Central

31 July 2017

Lisa A Collins-Racie

8

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Europe PubMed Central

31 July 2017

Edward R LaVallie

9

1 reference

Europe PubMed Central

31 July 2017

Elisabeth A Morris

10

1 reference

Europe PubMed Central

31 July 2017

John D Sandy

11

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31 July 2017

language of work or name

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publication date

19 February 2002

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Europe PubMed Central

31 July 2017

Journal of Biological Chemistry

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Europe PubMed Central

31 July 2017

277

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Europe PubMed Central

31 July 2017

18

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Europe PubMed Central

31 July 2017

16059-16066

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Europe PubMed Central

31 July 2017

Fibulin-1 is a ligand for the C-type lectin domains of aggrecan and versican.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108607200

21 January 2018

The proteoglycans aggrecan and Versican form networks with fibulin-2 through their lectin domain binding

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108607200

21 January 2018

The cartilage proteoglycan aggregate: assembly through combined protein-carbohydrate and protein-protein interactions

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108607200

21 January 2018

Aggrecan degradation in human cartilage. Evidence for both matrix metalloproteinase and aggrecanase activity in normal, osteoarthritic, and rheumatoid joints

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108607200

21 January 2018

Changes in joint cartilage aggrecan after knee injury and in osteoarthritis.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108607200

21 January 2018

Cathepsin B: an alternative protease for the generation of an aggrecan 'metalloproteinase' cleavage neoepitope

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108607200

21 January 2018

Aggrecan is degraded by matrix metalloproteinases in human arthritis. Evidence that matrix metalloproteinase and aggrecanase activities can be independent

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108607200

21 January 2018

Development of a cleavage-site-specific monoclonal antibody for detecting metalloproteinase-derived aggrecan fragments: detection of fragments in human synovial fluids

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108607200

21 January 2018

Analysis of aggrecan in human knee cartilage and synovial fluid indicates that aggrecanase (ADAMTS) activity is responsible for the catabolic turnover and loss of whole aggrecan whereas other protease activity is required for C-terminal processing i

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108607200

21 January 2018

The structure of aggrecan fragments in human synovial fluid. Evidence for the involvement in osteoarthritis of a novel proteinase which cleaves the Glu 373-Ala 374 bond of the interglobular domain

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108607200

21 January 2018

Purification and cloning of aggrecanase-1: a member of the ADAMTS family of proteins

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108607200

21 January 2018

Mechanisms involved in cartilage proteoglycan catabolism

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108607200

21 January 2018

Cell-mediated catabolism of aggrecan. Evidence that cleavage at the "aggrecanase" site (Glu373-Ala374) is a primary event in proteolysis of the interglobular domain

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108607200

21 January 2018

The use of cleavage site specific antibodies to delineate protein processing and breakdown pathways

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108607200

21 January 2018

Improved vectors for stable expression of foreign genes in mammalian cells by use of the untranslated leader sequence from EMC virus

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108607200

21 January 2018

Tight control of gene expression in mammalian cells by tetracycline-responsive promoters

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108607200

21 January 2018

Isolation of Chinese hamster cell mutants deficient in dihydrofolate reductase activity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108607200

21 January 2018

Calculation of protein extinction coefficients from amino acid sequence data

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108607200

21 January 2018

Neutrophil collagenase (MMP-8) cleaves at the aggrecanase site E373-A374 in the interglobular domain of cartilage aggrecan

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108607200

21 January 2018

Membrane type 1 matrix metalloproteinase (MT1-MMP) cleaves the recombinant aggrecan substrate rAgg1mut at the 'aggrecanase' and the MMP sites. Characterization of MT1-MMP catabolic activities on the interglobular domain of aggrecan

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108607200

21 January 2018

Sites of aggrecan cleavage by recombinant human aggrecanase-1 (ADAMTS-4)

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108607200

21 January 2018

The thrombospondin motif of aggrecanase-1 (ADAMTS-4) is critical for aggrecan substrate recognition and cleavage

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108607200

21 January 2018

Generation and novel distribution of matrix metalloproteinase-derived aggrecan fragments in porcine cartilage explants.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108607200

21 January 2018

Truncation of the amino-terminus of the recombinant aggrecan rAgg1mut leads to reduced cleavage at the aggrecanase site. Efficient aggrecanase catabolism may depend on multiple substrate interactions

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108607200

21 January 2018

Enzymes active in the areas undergoing cartilage resorption during the development of the secondary ossification center in the tibiae of rats ages 0-21 days: I. Two groups of proteinases cleave the core protein of aggrecan

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108607200

21 January 2018

Effects of injurious compression on matrix turnover around individual cells in calf articular cartilage explants

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108607200

21 January 2018

Physical and biological regulation of proteoglycan turnover around chondrocytes in cartilage explants. Implications for tissue degradation and repair

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108607200

21 January 2018

Age-related changes in cartilage proteoglycans: quantitative electron microscopic studies

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108607200

21 January 2018

Degradation of type II collagen, but not proteoglycan, correlates with matrix metalloproteinase activity in cartilage explant cultures

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108607200

21 January 2018

Mannosamine inhibits aggrecanase-mediated changes in the physical properties and biochemical composition of articular cartilage

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108607200

21 January 2018

The structure of aggrecan fragments in human synovial fluid. Evidence that aggrecanase mediates cartilage degradation in inflammatory joint disease, joint injury, and osteoarthritis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108607200

21 January 2018

Recombinant human aggrecan G1-G2 exhibits native binding properties and substrate specificity for matrix metalloproteinases and aggrecanase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108607200

21 January 2018

TIMP-3 is a potent inhibitor of aggrecanase 1 (ADAM-TS4) and aggrecanase 2 (ADAM-TS5)

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108607200

21 January 2018

Inhibition of ADAMTS4 (aggrecanase-1) by tissue inhibitors of metalloproteinases (TIMP-1, 2, 3 and 4)

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108607200

21 January 2018

The interglobular domain of cartilage aggrecan is cleaved by hemorrhagic metalloproteinase HT-d (atrolysin C) at the matrix metalloproteinase and aggrecanase sites

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108607200

21 January 2018

Generation and characterization of aggrecanase. A soluble, cartilage-derived aggrecan-degrading activity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108607200

21 January 2018

Matrix metalloproteinases and aggrecanases cleave aggrecan in different zones of normal cartilage but colocalize in the development of osteoarthritic lesions in STR/ort mice

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108607200

21 January 2018

Kinetics of aggrecanase- and metalloproteinase-induced neoepitopes in various stages of cartilage destruction in murine arthritis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108607200

21 January 2018

Aggrecanase versus matrix metalloproteinases in the catabolism of the interglobular domain of aggrecan in vitro.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108607200

21 January 2018

Cleavage of native cartilage aggrecan by neutrophil collagenase (MMP-8) is distinct from endogenous cleavage by aggrecanase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108607200

21 January 2018

Age-related changes in aggrecan glycosylation affect cleavage by aggrecanase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108607200

21 January 2018

The role of ADAM-TS4 (aggrecanase-1) and ADAM-TS5 (aggrecanase-2) in a model of cartilage degradation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M108607200

21 January 2018

Identifiers

10.1074/JBC.M108607200

1 reference

Europe PubMed Central

31 July 2017

1 reference

Europe PubMed Central

31 July 2017

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