Recombinant human aggrecan G1-G2 exhibits native binding properties and substrate specificity for matrix metalloproteinases and aggrecanase (Q73133824)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10542281%20AND%20SRC:MED&resulttype=core&format=json

1 November 2019

title

Recombinant human aggrecan G1-G2 exhibits native binding properties and substrate specificity for matrix metalloproteinases and aggrecanase (English)

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1 November 2019

1

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1 November 2019

Karena Last

5

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1 November 2019

Amanda Fosang

6

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1 November 2019

author name string

K J Doege

2

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1 November 2019

E C Arner

3

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1 November 2019

M A Pratta

4

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language of work or name

English

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publication date

1 November 1999

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Journal of Biological Chemistry

1 November 2019

published in

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1 November 2019

volume

274

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issue

45

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1 November 2019

page(s)

32387-32395

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Articular cartilage cultured with interleukin 1. Increased release of link protein, hyaluronate-binding region and other proteoglycan fragments

1 November 2019

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Mechanism of catabolism of aggrecan by articular cartilage

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N-terminal sequence of proteoglycan fragments isolated from medium of interleukin-1-treated articular-cartilage cultures. Putative site(s) of enzymic cleavage

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The structure of aggrecan fragments in human synovial fluid. Evidence for the involvement in osteoarthritis of a novel proteinase which cleaves the Glu 373-Ala 374 bond of the interglobular domain

21 January 2018

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The structure of aggrecan fragments in human synovial fluid. Evidence that aggrecanase mediates cartilage degradation in inflammatory joint disease, joint injury, and osteoarthritis

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VDIPEN, a metalloproteinase-generated neoepitope, is induced and immunolocalized in articular cartilage during inflammatory arthritis

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Aggrecan is degraded by matrix metalloproteinases in human arthritis. Evidence that matrix metalloproteinase and aggrecanase activities can be independent

21 January 2018

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Aggrecan degradation in human cartilage. Evidence for both matrix metalloproteinase and aggrecanase activity in normal, osteoarthritic, and rheumatoid joints

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Aggrecan degradation in human intervertebral disc and articular cartilage

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Fibroblast and neutrophil collagenases cleave at two sites in the cartilage aggrecan interglobular domain

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Degradation of cartilage aggrecan by collagenase-3 (MMP-13)

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Membrane-type 1 MMP (MMP-14) cleaves at three sites in the aggrecan interglobular domain

21 January 2018

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Neutrophil collagenase (MMP-8) cleaves at the aggrecanase site E373-A374 in the interglobular domain of cartilage aggrecan

21 January 2018

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Cleavage of native cartilage aggrecan by neutrophil collagenase (MMP-8) is distinct from endogenous cleavage by aggrecanase

21 January 2018

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The interglobular domain of cartilage aggrecan is cleaved by hemorrhagic metalloproteinase HT-d (atrolysin C) at the matrix metalloproteinase and aggrecanase sites

21 January 2018

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Purification and cloning of aggrecanase-1: a member of the ADAMTS family of proteins

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Monoclonal antibodies that specifically recognize neoepitope sequences generated by 'aggrecanase' and matrix metalloproteinase cleavage of aggrecan: application to catabolism in situ and in vitro

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Cell-mediated catabolism of aggrecan. Evidence that cleavage at the "aggrecanase" site (Glu373-Ala374) is a primary event in proteolysis of the interglobular domain

21 January 2018

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Development of a cleavage-site-specific monoclonal antibody for detecting metalloproteinase-derived aggrecan fragments: detection of fragments in human synovial fluids

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Quantification of a matrix metalloproteinase-generated aggrecan G1 fragment using monospecific anti-peptide serum

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Differential Expression of Aggrecanase and Matrix Metalloproteinase Activity in Chondrocytes Isolated from Bovine and Porcine Articular Cartilage

21 January 2018

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Purification of recombinant human prostromelysin. Studies on heat activation to give high-Mr and low-Mr active forms, and a comparison of recombinant with natural stromelysin activities

21 January 2018

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Matrix metalloproteinase degradation of elastin, type IV collagen and proteoglycan. A quantitative comparison of the activities of 95 kDa and 72 kDa gelatinases, stromelysins-1 and -2 and punctuated metalloproteinase (PUMP).

21 January 2018

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The purification of tissue inhibitor of metalloproteinases-2 from its 72 kDa progelatinase complex. Demonstration of the biochemical similarities of tissue inhibitor of metalloproteinases-2 and tissue inhibitor of metalloproteinases-1.

21 January 2018

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Characteristics of the core protein of the aggregating proteoglycan from the Swarm rat chondrosarcoma

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Isolation of the N-terminal globular protein domains from cartilage proteoglycans. Identification of G2 domain and its lack of interaction with hyaluronate and link protein

21 January 2018

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Generation and characterization of aggrecanase. A soluble, cartilage-derived aggrecan-degrading activity

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Biochemical analysis of the N-glycosylation pathway in baculovirus-infected lepidopteran insect cells.

21 January 2018

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Microheterogeneity of the oligosaccharides carried by the recombinant bovine lactoferrin expressed in Mamestra brassicae cells.

21 January 2018

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Structural analysis and localization of the carbohydrate moieties of a soluble human interferon gamma receptor produced in baculovirus-infected insect cells

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.274.45.32387

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10542281%20AND%20SRC:MED&resulttype=core&format=json

1 November 2019

1 reference