Animal models of autoimmunity and their relevance to human diseases (Q34096254)

31 July 2017

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title

Animal models of autoimmunity and their relevance to human diseases (English)

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31 July 2017

Sakaguchi S

1

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31 July 2017

1 December 2000

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Current Opinion in Immunology

31 July 2017

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31 July 2017

12

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31 July 2017

684-690

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31 July 2017

6

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Homeostasis and self-tolerance in the immune system: turning lymphocytes off.

31 July 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2800%2900163-1

7 January 2021

Abnormal T cell selection on nod thymic epithelium is sufficient to induce autoimmune manifestations in C57BL/6 athymic nude mice

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https://api.crossref.org/works/10.1016%2FS0952-7915%2800%2900163-1

7 January 2021

MHC structure and autoimmune T cell repertoire development

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https://api.crossref.org/works/10.1016%2FS0952-7915%2800%2900163-1

7 January 2021

The third function of the thymus.

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2800%2900163-1

7 January 2021

Endogenous myelin basic protein inactivates the high avidity T cell repertoire

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https://api.crossref.org/works/10.1016%2FS0952-7915%2800%2900163-1

7 January 2021

Differential tolerance is induced in T cells recognizing distinct epitopes of myelin basic protein.

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2800%2900163-1

7 January 2021

T-cell responses to myelin basic protein in normal and MBP-deficient mice

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https://api.crossref.org/works/10.1016%2FS0952-7915%2800%2900163-1

7 January 2021

Peripheral-antigen-expressing cells in thymic medulla: factors in self-tolerance and autoimmunity

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2800%2900163-1

7 January 2021

Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2 locus.

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2800%2900163-1

7 January 2021

The insulin gene is transcribed in the human thymus and transcription levels correlated with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes.

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2800%2900163-1

7 January 2021

The role of MHC class II molecules in susceptibility and resistance to autoimmunity

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2800%2900163-1

7 January 2021

Autoimmunity caused by disruption of central T cell tolerance. A murine model of drug-induced lupus

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https://api.crossref.org/works/10.1016%2FS0952-7915%2800%2900163-1

7 January 2021

Disruption of positive selection of thymocytes causes autoimmunity

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https://api.crossref.org/works/10.1016%2FS0952-7915%2800%2900163-1

7 January 2021

Probing degeneracy in T-cell recognition using peptide combinatorial libraries

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https://api.crossref.org/works/10.1016%2FS0952-7915%2800%2900163-1

7 January 2021

Selection of the T cell repertoire.

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https://api.crossref.org/works/10.1016%2FS0952-7915%2800%2900163-1

7 January 2021

Selecting and maintaining a diverse T-cell repertoire

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https://api.crossref.org/works/10.1016%2FS0952-7915%2800%2900163-1

7 January 2021

Activation of autoreactive T cells by peptides from human pathogens

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https://api.crossref.org/works/10.1016%2FS0952-7915%2800%2900163-1

7 January 2021

Identification of a cross-reactive self ligand in virus-mediated autoimmunity

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2800%2900163-1

7 January 2021

From systemic T cell self-reactivity to organ-specific autoimmune disease via immunoglobulins

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https://api.crossref.org/works/10.1016%2FS0952-7915%2800%2900163-1

7 January 2021

Arthritis provoked by linked T and B cell recognition of a glycolytic enzyme

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2800%2900163-1

7 January 2021

The arthritogenic T cell receptor and its ligand in a model of spontaneous arthritis

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2800%2900163-1

7 January 2021

A structural framework for deciphering the link between I-Ag7 and autoimmune diabetes

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https://api.crossref.org/works/10.1016%2FS0952-7915%2800%2900163-1

7 January 2021

Dendritic cells induce autoimmune diabetes and maintain disease via de novo formation of local lymphoid tissue

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https://api.crossref.org/works/10.1016%2FS0952-7915%2800%2900163-1

7 January 2021

Role of antigen-presenting cells in mediating tolerance and autoimmunity

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2800%2900163-1

7 January 2021

The induction of tolerance by dendritic cells that have captured apoptotic cells

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2800%2900163-1

7 January 2021

Cross-tolerance: a pathway for inducing tolerance to peripheral tissue antigens

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2800%2900163-1

7 January 2021

Regulatory T cells: key controllers of immunologic self-tolerance

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2800%2900163-1

7 January 2021

Thymus and Reproduction: Sex-Linked Dysgenesia of the Gonad after Neonatal Thymectomy in Mice

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2800%2900163-1

7 January 2021

Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2800%2900163-1

7 January 2021

Autoimmune ovarian disease: mechanism of disease induction and prevention

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2800%2900163-1

7 January 2021

The causative H+/K+ ATPase antigen in the pathogenesis of autoimmune gastritis.

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2800%2900163-1

7 January 2021

Organ-specific autoimmunity induced by adult thymectomy and cyclophosphamide-induced lymphopenia

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https://api.crossref.org/works/10.1016%2FS0952-7915%2800%2900163-1

7 January 2021

Evidence that the T cell repertoire of normal rats contains cells with the potential to cause diabetes. Characterization of the CD4+ T cell subset that inhibits this autoimmune potential

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2800%2900163-1

7 January 2021

CD4+CD25+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2800%2900163-1

7 January 2021

Immunologic self-tolerance maintained by CD25+CD4+ naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2800%2900163-1

7 January 2021

B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2800%2900163-1

7 January 2021

Immunologic self-tolerance maintained by CD25(+)CD4(+) regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4.

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2800%2900163-1

7 January 2021

Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD25(+)CD4(+) regulatory cells that control intestinal inflammation

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2800%2900163-1

7 January 2021

Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) regulates the unfolding of autoimmune diabetes

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https://api.crossref.org/works/10.1016%2FS0952-7915%2800%2900163-1

7 January 2021

CTLA4 alanine-17 confers genetic susceptibility to Graves' disease and to type 1 diabetes mellitus.

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https://api.crossref.org/works/10.1016%2FS0952-7915%2800%2900163-1

7 January 2021

Insulin-dependent diabetes mellitus (IDDM) is associated with CTLA4 polymorphisms in multiple ethnic groups

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2800%2900163-1

7 January 2021

Regulatory T cells in the control of autoimmunity: the essential role of transforming growth factor beta and interleukin 4 in the prevention of autoimmune thyroiditis in rats by peripheral CD4(+)CD45RC- cells and CD4(+)CD8(-) thymocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2800%2900163-1

7 January 2021

Suppressor effector function of CD4+CD25+ immunoregulatory T cells is antigen nonspecific

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2800%2900163-1

7 January 2021

Characterization of peripheral regulatory CD4+ T cells that prevent diabetes onset in nonobese diabetic mice

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2800%2900163-1

7 January 2021

alpha/beta-T cell receptor (TCR)+CD4-CD8- (NKT) thymocytes prevent insulin-dependent diabetes mellitus in nonobese diabetic (NOD)/Lt mice by the influence of interleukin (IL)-4 and/or IL-10.

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2800%2900163-1

7 January 2021

Extreme Th1 bias of invariant Valpha24JalphaQ T cells in type 1 diabetes.

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2800%2900163-1

7 January 2021

CD4+ T-cell subsets in autoimmunity

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2800%2900163-1

7 January 2021

Autoreactive CD4+ T cells protect from autoimmune diabetes via bystander suppression using the IL-4/Stat6 pathway.

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2800%2900163-1

7 January 2021

Anergic T cells actively suppress T cell responses via the antigen-presenting cell

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2800%2900163-1

7 January 2021

Regulatory T cells in autoimmmunity*.

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2800%2900163-1

7 January 2021

APECED: a monogenic autoimmune disease providing new clues to self-tolerance

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2800%2900163-1

7 January 2021

An autoimmune disease, APECED, caused by mutations in a novel gene featuring two PHD-type zinc-finger domains

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2800%2900163-1

7 January 2021

Positional cloning of the APECED gene

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2800%2900163-1

7 January 2021

Autoimmune regulator is expressed in the cells regulating immune tolerance in thymus medulla.

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2800%2900163-1

7 January 2021

HIGH FREQUENCY OF DIABETES MELLITUS IN YOUNG ADULTS WITH CONGENITAL RUBELLA

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2800%2900163-1

7 January 2021

Diabetes mellitus, endocrine autoantibodies, and prenatal rubella infection

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2800%2900163-1

7 January 2021

Diabetes mellitus and autoimmunity in patients with the congenital rubella syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2800%2900163-1

7 January 2021

Pulsed monoclonal antibody treatment and autoimmune thyroid disease in multiple sclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2800%2900163-1

7 January 2021

10.1016/S0952-7915(00)00163-1

Identifiers

DOI

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31 July 2017

1 reference

PubMed ID

11102773