A novel Chk inhibitor, XL-844, increases human cancer cell radiosensitivity through promotion of mitotic catastrophe (Q34089160)

30 July 2017

A novel Chk inhibitor, XL-844, increases human cancer cell radiosensitivity through promotion of mitotic catastrophe (English)

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30 July 2017

Oliver Riesterer

1

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30 July 2017

Fumihiko Matsumoto

2

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30 July 2017

Li Wang

3

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30 July 2017

Jessica Pickett

4

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30 July 2017

David Molkentine

5

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30 July 2017

Uma Giri

6

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30 July 2017

Luka Milas

7

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30 July 2017

Uma Raju

8

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30 July 2017

22 December 2009

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Investigational New Drugs

30 July 2017

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30 July 2017

29

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30 July 2017

3

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30 July 2017

514-522

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https://scigraph.springernature.com/pub.10.1007/s10637-009-9361-2

30 July 2017

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cites work

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Activation of the ATM kinase by ionizing radiation and phosphorylation of p53

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Cell cycle checkpoints: preventing an identity crisis

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Radiosensitivity in ataxia-telangiectasia: a new explanation

21 January 2018

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Mammalian Chk2 is a downstream effector of the ATM-dependent DNA damage checkpoint pathway

21 January 2018

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Targeting chk2 kinase: molecular interaction maps and therapeutic rationale

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CHK2 kinase--a busy messenger.

21 January 2018

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Regulation of the G2/M transition by p53.

21 January 2018

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Radiation and new molecular agents part I: targeting ATM-ATR checkpoints, DNA repair, and the proteasome

21 January 2018

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Two molecularly distinct G(2)/M checkpoints are induced by ionizing irradiation

21 January 2018

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Pharmacological abrogation of S-phase checkpoint enhances the anti-tumor activity of gemcitabine in vivo

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Inherent cellular radiosensitivity as a basic concept for human tumor radiotherapy.

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CHK2 kinase: cancer susceptibility and cancer therapy - two sides of the same coin?

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Linkage of ATM to cell cycle regulation by the Chk2 protein kinase

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CHIR-124, a novel potent inhibitor of Chk1, potentiates the cytotoxicity of topoisomerase I poisons in vitro and in vivo

21 January 2018

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A novel mechanism of checkpoint abrogation conferred by Chk1 downregulation

21 January 2018

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Checkpoint kinase 1 down-regulation by an inducible small interfering RNA expression system sensitized in vivo tumors to treatment with 5-fluorouracil.

21 January 2018

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Inhibition of Chk1-dependent G2 DNA damage checkpoint radiosensitizes p53 mutant human cells

21 January 2018

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Disruption of the checkpoint kinase 1/cell division cycle 25A pathway abrogates ionizing radiation-induced S and G2 checkpoints

21 January 2018

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Mechanisms of p34cdc2 regulation

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CDC25 phosphatases as potential human oncogenes

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ATM--a key determinant of multiple cellular responses to irradiation

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Inhibition of DNA repair as a mechanism of enhanced radioresponse of head and neck carcinoma cells by a selective cyclooxygenase-2 inhibitor, celecoxib

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Inhibition of human Chk1 causes increased initiation of DNA replication, phosphorylation of ATR targets, and DNA breakage

21 January 2018

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Real-time visualization of cell cycle-dependent changes in microtubule dynamics in cytoplasmic extracts

21 January 2018

1 reference

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Cell cycle disturbances and mitotic catastrophes in HeLa Hep2 cells following 2.5 to 10 Gy of ionizing radiation.

21 January 2018

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DNA mismatch repair and Chk1-dependent centrosome amplification in response to DNA alkylation damage.

21 January 2018

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The cell cycle checkpoint kinase Chk2 is a negative regulator of mitotic catastrophe

21 January 2018

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If not apoptosis, then what? Treatment-induced senescence and mitotic catastrophe in tumor cells

21 January 2018

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The tubulin-depolymerising agent combretastatin-4 induces ectopic aster assembly and mitotic catastrophe in lung cancer cells H460.

21 January 2018

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The role of apoptosis in cancer development and treatment response

21 January 2018

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Depletion of Chk1 leads to premature activation of Cdc2-cyclin B and mitotic catastrophe

21 January 2018

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Dynamic instability of microtubule growth

21 January 2018

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Identification of gamma-tubulin, a new member of the tubulin superfamily encoded by mipA gene of Aspergillus nidulans.

21 January 2018

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Keeping checkpoint kinases in line: new selective inhibitors in clinical trials

21 January 2018

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12 December 2020

Cell biology: Microtubule catastrophe

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12 December 2020

Threonine 68 phosphorylation by ataxia telangiectasia mutated is required for efficient activation of Chk2 in response to ionizing radiation

1 reference

12 December 2020

Linking DNA damage to cell cycle checkpoints.

1 reference

12 December 2020

Regulation of the human WEE1Hu CDK tyrosine 15-kinase during the cell cycle

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12 December 2020

UCN-01 inhibits p53 up-regulation and abrogates gamma-radiation-induced G(2)-M checkpoint independently of p53 by targeting both of the checkpoint kinases, Chk2 and Chk1.

1 reference

12 December 2020

Cellular inhibition of checkpoint kinase 2 (Chk2) and potentiation of camptothecins and radiation by the novel Chk2 inhibitor PV1019 [7-nitro-1H-indole-2-carboxylic acid {4-[1-(guanidinohydrazone)-ethyl]-phenyl}-amide].

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12 December 2020

The radiosensitizing agent 7-hydroxystaurosporine (UCN-01) inhibits the DNA damage checkpoint kinase hChk1

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12 December 2020

10.1007/S10637-009-9361-2

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DOI

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Dimensions Publication ID

30 July 2017

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