Alloantigen-specific regulatory T cells generated with a chimeric antigen receptor (Q34046489)

30 July 2017

Alloantigen-specific regulatory T cells generated with a chimeric antigen receptor (English)

1 reference

30 July 2017

Romy E Hoeppli

2

0 references

Dan S Luciani

object named as

Dan S Luciani

5

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Megan K. Levings

object named as

Megan K Levings

8

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author name string

Katherine G MacDonald

1

1 reference

30 July 2017

Qing Huang

3

1 reference

30 July 2017

Jana Gillies

4

1 reference

30 July 2017

Paul C Orban

6

1 reference

30 July 2017

Raewyn Broady

7

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30 July 2017

language of work or name

English

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publication date

21 March 2016

1 reference

Journal of Clinical Investigation

30 July 2017

1 reference

30 July 2017

126

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30 July 2017

1413-1424

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30 July 2017

4

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describes a project that uses

30 July 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4811124/fullTextXML

inferred from PubMed Central ID database lookup

cites work

Type 1 diabetes immunotherapy using polyclonal regulatory T cells

1 reference

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Epigenetic analysis of regulatory T cells using multiplex bisulfite sequencing.

5 July 2018

1 reference

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4-1BB costimulation ameliorates T cell exhaustion induced by tonic signaling of chimeric antigen receptors

5 July 2018

1 reference

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Regulatory T cells require TCR signaling for their suppressive function

5 July 2018

1 reference

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Adoptive cellular therapy: a race to the finish line.

5 July 2018

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Identification of chimeric antigen receptors that mediate constitutive or inducible proliferation of T cells

5 July 2018

1 reference

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Going viral: chimeric antigen receptor T-cell therapy for hematological malignancies

5 July 2018

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Chimeric antigen receptor T cells for sustained remissions in leukemia

5 July 2018

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Continuous requirement for the TCR in regulatory T cell function

5 July 2018

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Suppression of murine colitis and its associated cancer by carcinoembryonic antigen-specific regulatory T cells

5 July 2018

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Antibody-modified T cells: CARs take the front seat for hematologic malignancies

5 July 2018

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Signals and pathways controlling regulatory T cells

5 July 2018

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Clinical grade manufacturing of human alloantigen-reactive regulatory T cells for use in transplantation.

5 July 2018

1 reference

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Adoptive transfer of umbilical cord blood-derived regulatory T cells and early viral reactivation

5 July 2018

1 reference

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The basic principles of chimeric antigen receptor design

5 July 2018

1 reference

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An obligate cell-intrinsic function for CD28 in Tregs

5 July 2018

1 reference

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Role of HLA in Hematopoietic Stem Cell Transplantation

5 July 2018

1 reference

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The Role of the PI3K Signaling Pathway in CD4(+) T Cell Differentiation and Function

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4811124

Administration of CD4+CD25highCD127- regulatory T cells preserves β-cell function in type 1 diabetes in children

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4811124

CAR/FoxP3-engineered T regulatory cells target the CNS and suppress EAE upon intranasal delivery.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4811124

Sustained suppression by Foxp3+ regulatory T cells is vital for infectious transplantation tolerance

5 July 2018

1 reference

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Engineered artificial antigen presenting cells facilitate direct and efficient expansion of tumor infiltrating lymphocytes

5 July 2018

1 reference

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Human regulatory T cells with alloantigen specificity are more potent inhibitors of alloimmune skin graft damage than polyclonal regulatory T cells

5 July 2018

1 reference

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Massive ex vivo expansion of human natural regulatory T cells (T(regs)) with minimal loss of in vivo functional activity

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4811124

Tregs prevent GVHD and promote immune reconstitution in HLA-haploidentical transplantation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4811124

Infusion of ex vivo expanded T regulatory cells in adults transplanted with umbilical cord blood: safety profile and detection kinetics

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4811124

Redirecting human CD4+CD25+ regulatory T cells from the peripheral blood with pre-defined target specificity

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4811124

Regulating the regulators: costimulatory signals control the homeostasis and function of regulatory T cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4811124

Curing CNS autoimmune disease with myelin-reactive Foxp3+ Treg

5 July 2018

1 reference

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The promise and potential pitfalls of chimeric antigen receptors

5 July 2018

1 reference

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Adoptive cell therapy for the treatment of patients with metastatic melanoma

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4811124

Amelioration of colitis by genetically engineered murine regulatory T cells redirected by antigen-specific chimeric receptor.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4811124

Redirection of regulatory T cells with predetermined specificity for the treatment of experimental colitis in mice

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4811124

Induction of antigen-specific regulatory T cells in wild-type mice: visualization and targets of suppression

5 July 2018

1 reference

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Prevention of acute and chronic allograft rejection with CD4+CD25+Foxp3+ regulatory T lymphocytes

5 July 2018

1 reference

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Generation of potent and stable human CD4+ T regulatory cells by activation-independent expression of FOXP3.

5 July 2018

1 reference

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Dendritic cell-expanded, islet-specific CD4+ CD25+ CD62L+ regulatory T cells restore normoglycemia in diabetic NOD mice

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4811124

Ex vivo-expanded CD4+CD25+ immunoregulatory T cells prevent graft-versus-host-disease by inhibiting activation/differentiation of pathogenic T cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4811124

Specificity of CD4+CD25+ regulatory T cell function in alloimmunity

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4811124

Human T regulatory cells can use the perforin pathway to cause autologous target cell death

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4811124

CD25+ CD4+ T cells, expanded with dendritic cells presenting a single autoantigenic peptide, suppress autoimmune diabetes.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4811124

In vitro-expanded antigen-specific regulatory T cells suppress autoimmune diabetes

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4811124

Human cd25(+)cd4(+) t regulatory cells suppress naive and memory T cell proliferation and can be expanded in vitro without loss of function.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4811124

CD4+CD25+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4811124

A novel strategy for generating monoclonal antibodies from single, isolated lymphocytes producing antibodies of defined specificities

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4811124

Continuous T cell receptor signals maintain a functional regulatory T cell pool.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4811124

Helios+ and Helios- cells coexist within the natural FOXP3+ T regulatory cell subset in humans

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4811124

Molecular modeling and affinity determination of scFv antibody: proper linker peptide enhances its activity

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4811124

Loss of FOXP3 expression in natural human CD4+CD25+ regulatory T cells upon repetitive in vitro stimulation.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4811124

Conferring indirect allospecificity on CD4+CD25+ Tregs by TCR gene transfer favors transplantation tolerance in mice.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4811124

Only the CD45RA+ subpopulation of CD4+CD25high T cells gives rise to homogeneous regulatory T-cell lines upon in vitro expansion.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4811124

Monospecific bivalent scFv-SH: effects of linker length and location of an engineered cysteine on production, antigen binding activity and free SH accessibility

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4811124

Expansion of functional endogenous antigen-specific CD4+CD25+ regulatory T cells from nonobese diabetic mice

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4811124

Induction of antigen-specific immunologic tolerance by in vivo and in vitro antigen-specific expansion of naturally arising Foxp3+CD25+CD4+ regulatory T cells.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4811124

Growth and expansion of human T regulatory type 1 cells are independent from TCR activation but require exogenous cytokines

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4811124

In vitro-expanded donor alloantigen-specific CD4+CD25+ regulatory T cells promote experimental transplantation tolerance

28 October 2018

1 reference

12 December 2020

Discarded Human Thymus Is a Novel Source of Stable and Long-Lived Therapeutic Regulatory T Cells

1 reference

12 December 2020

Measuring T-cell-mediated cytotoxicity using antibody to activated caspase 3

1 reference

12 December 2020

Total body irradiation and acute graft-versus-host disease: the role of gastrointestinal damage and inflammatory cytokines

1 reference

12 December 2020

The relative frequencies of HLA-DRB1*01 alleles in the major US populations

1 reference

12 December 2020

First-in-man clinical results of the treatment of patients with graft versus host disease with human ex vivo expanded CD4+CD25+CD127- T regulatory cells

1 reference

12 December 2020

Pancreatic lymph node-derived CD4(+)CD25(+) Treg cells: highly potent regulators of diabetes that require TRANCE-RANK signals

1 reference

12 December 2020

An experimental model of idiopathic pneumonia syndrome after bone marrow transplantation: I. The roles of minor H antigens and endotoxin

1 reference

12 December 2020

Role of the mixed lymphocyte culture (MLC) reaction in marrow donor selection: matching for transplants from related haploidentical donors

1 reference

12 December 2020

Identifiers

DOI

10.1172/JCI82771

1 reference

30 July 2017

1 reference

30 July 2017

1 reference